P112. Role of metabolites in bio-fluids as a prognostic indicator of neurological recovery in acute spinal cord injury (ASCI)

2020 ◽  
Vol 20 (9) ◽  
pp. S200
Author(s):  
Rajeshwar N. Srivastava ◽  
Dr Alka Singh ◽  
Saloni Raj
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Prognostic Indicator ◽  
Acute Spinal Cord Injury ◽  
Neurological Recovery ◽  
Cord Injury

scholarly journals Comparison of Surgical and Conservative Management in 208 Patients with Acute Spinal Cord Injury

1987 ◽  
Vol 14 (S1) ◽  
pp. 60-69 ◽  
Author(s):  
C.H. Tator ◽  
E.G. Duncan ◽  
V.E. Edmonds ◽  
L.I. Lapczak ◽  
D.F. Andrews
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mortality Rate ◽  
Cauda Equina ◽  
Acute Spinal Cord Injury ◽  
Neurological Recovery ◽  
Time Interval ◽  
Cord Injury ◽  
Unit Time Interval

ABSTRACT:The role of surgery in the management of acute spinal cord or cauda equina injuries remains controversial. The present study analyzed ten admission features and three outcome variables in 208 patients treated in an Acute Spinal Cord Injury Unit, 116 (56%) of whom underwent at least one spinal operation. The surgical and non-surgical groups showed no significant differences in the following seven clinical features: age, sex, distance travelled to the Unit, time interval between trauma and admission, type of accident, severity of injuries to the spinal cord, and severity of associated injuries. However, the two groups showed significant differences in level and type of vertebral column injury, and in the frequency of pre-existing spinal abnormalities. These differences were due to management policies which selected certain injuries for surgical or non-surgical treatment. One-third of the operative procedures were performed primarily for neural decompression, one-third primarily for reduction of bony structures and one-third for fusion. However, 95% of the operative patients had a fusion at the initial operation. Operative treatment was associated with a lower overall mortality rate (6.1%) than non-operative (15.2%), despite a higher frequency of thrombo-embolic complications in the surgical group. Overall, there was no difference between operated and non-operated patients in length of stay or neurological recovery. Surgical management of patients with acute spinal cord injury appears safe in terms of mortality rate and neurological recovery, but it has not been proven to improve the latter.

scholarly journals Role of melatonin in the dynamics of acute spinal cord injury in rats

2021 ◽  
Author(s):  
Jiaqi Bi ◽  
Jianxiong Shen ◽  
Chong Chen ◽  
Zheng Li ◽  
Haining Tan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals Role of methyleprednisolone succinate in the management of acute spinal cord injury

1970 ◽  
Vol 9 (3) ◽  
pp. 168-172
Author(s):  
NK Karn ◽  
BP Shrestha ◽  
GP Khanal ◽  
R Rijal ◽  
P Chaudhary ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Status ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
And Gender ◽  
One Year

Objective: To see the role of methyleprednisolone succinate in the management of acute spinal cord injury. Methods: A randomized control trial was done including the patients with acute spinal cord injury. They were divided into age and gender matched two groups. Patients with presence of active infection, associated open fracture, those on long term steroid and those who did not give consent to participate in the trial were excluded. One group received methyleprednisolone succinate within 8 hours of injury and another group did not receive the drug. Both the groups were managed nonoperatively. The neurological status of the patients was assessed at presentation, once spinal shock was over, at 6th week and 6th month and after one year according to ASIA scoring. Frankel grading was also assessed in every follow up. Conclusion: Methylprednisolone succinct prevents secondary cord injury to a great extent and hence its administration within 8 hours of injury results in a better functional (motor and sensory) outcome. Keywords: acute spinal cord injury; methyleprednisolone succinate DOI: http://dx.doi.org/10.3126/hren.v9i3.5585   HR 2011; 9(3): 168-172

scholarly journals The Role of Magnetic Resonance Imaging in the Management of Acute Spinal Cord Injury

2011 ◽  
Vol 28 (8) ◽  
pp. 1401-1411 ◽  
Author(s):  
Anthony Bozzo ◽  
Judith Marcoux ◽  
Mohan Radhakrishna ◽  
Julie Pelletier ◽  
Benoit Goulet
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Resonance ◽  
Acute Spinal Cord Injury ◽  
Resonance Imaging ◽  
Cord Injury

scholarly journals A Clinical Practice Guideline for the Management of Acute Spinal Cord Injury: Introduction, Rationale, and Scope

2017 ◽  
Vol 7 (3_suppl) ◽  
pp. 84S-94S ◽  
Author(s):  
Michael G. Fehlings ◽  
Lindsay A. Tetreault ◽  
Jefferson R. Wilson ◽  
Brian K. Kwon ◽  
Anthony S. Burns ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Traumatic Event ◽  
Sodium Succinate ◽  
Well Being ◽  
Acute Spinal Cord Injury ◽  
Optimal Timing ◽  
Past Century ◽  
Cord Injury

Acute spinal cord injury (SCI) is a traumatic event that results in disturbances to normal sensory, motor, or autonomic function and ultimately affects a patient’s physical, psychological, and social well-being. The management of patients with SCI has drastically evolved over the past century as a result of increasing knowledge on injury mechanisms, disease pathophysiology, and the role of surgery. There still, however, remain controversial areas surrounding available management strategies for the treatment of SCI, including the use of corticosteroids such as methylprednisolone sodium succinate, the optimal timing of surgical intervention, the type and timing of anticoagulation prophylaxis, the role of magnetic resonance imaging, and the type and timing of rehabilitation. This lack of consensus has prevented the standardization of care across treatment centers and among the various disciplines that encounter patients with SCI. The objective of this guideline is to form evidence-based recommendations for these areas of controversy and outline how to best manage patients with SCI. The ultimate goal of these guidelines is to improve outcomes and reduce morbidity in patients with SCI by promoting standardization of care and encouraging clinicians to make evidence-informed decisions.

Understanding Drug Disposition Alterations Induced by Acute Spinal Cord Injury: Role of Injury Level and Route of Administration for Agents Submitted to Extensive Liver Metabolism

2006 ◽  
Vol 23 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Leticia Cruz-Antonio ◽  
Francisco Javier Flores-Murrieta ◽  
Patricia García-Löpez ◽  
Gabriel Guízar-Sahagún ◽  
Gilberto Castañeda-Hernández
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Drug Disposition ◽  
Liver Metabolism ◽  
Route Of Administration ◽  
Acute Spinal Cord Injury ◽  
Cord Injury
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