P140. Risk factors for index level fusion following lumbar microdiscectomy

2021 ◽  
Vol 21 (9) ◽  
pp. S209-S210
Author(s):  
Zakariah Siyaji ◽  
Nicholas A. Shepard ◽  
Thomas B. Sullivan ◽  
Augustus J. Rush ◽  
Frank M. Phillips ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lumbar Microdiscectomy ◽  
Index Level ◽  
Level Fusion

scholarly journals Comparing the Incidence of Index Level Fusion Following Minimally Invasive Versus Open Lumbar Microdiscectomy

2017 ◽  
Vol 8 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Steven J. McAnany ◽  
Samuel C. Overley ◽  
Muhammad A. Anwar ◽  
Holt S. Cutler ◽  
Javier Z. Guzman ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Lumbar Microdiscectomy ◽  
Index Level ◽  
Level Fusion

Results and risk factors for recurrence following single-level tubular lumbar microdiscectomy

2010 ◽  
Vol 12 (6) ◽  
pp. 680-686 ◽  
Author(s):  
Jennifer A. Moliterno ◽  
Jared Knopman ◽  
Karishma Parikh ◽  
Jessica N. Cohan ◽  
Q. Daisy Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Lower Body ◽  
Single Level ◽  
Lower Body Mass Index ◽  
Lumbar Microdiscectomy ◽  
Nonobese Patients

Object The use of minimally invasive surgical techniques, including microscope-assisted tubular lumbar microdiscectomy (tLMD), has gained increasing popularity in treating lumbar disc herniations (LDHs). This particular procedure has been shown to be both cost-efficient and effective, resulting in outcomes comparable to those of open surgical procedures. Lumbar disc herniation recurrence necessitating reoperation, however, remains an issue following spinal surgery, with an overall reported incidence of approximately 3–13%. The authors' aim in the present study was to report their experience using tLMD for single-level LDH, hoping to provide further insight into the rate of surgical recurrence and to identify potential risk factors leading to this complication. Methods The authors retrospectively reviewed the cases of 217 patients who underwent tLMD for single-level LDH performed identically by 2 surgeons (J.B., R.H.) between 2004 and 2008. Evaluation for LDH recurrence included detailed medical chart review and telephone interview. Recurrent LDH was defined as the return of preoperative signs and symptoms after an interval of postoperative resolution, in conjunction with radiographic demonstration of ipsilateral disc herniation at the same level and pathological confirmation of disc material. A cohort of patients without recurrence was used for comparison to identify possible risk factors for recurrent LDH. Results Of the 147 patients for whom the authors were able to definitively assess symptomatic recurrence status, 14 patients (9.5%) experienced LDH recurrence following single-level tLMD. The most common level involved was L5–S1 (42.9%) and the mean length of time to recurrence was 12 weeks (range 1.5–52 weeks). Sixty-four percent of the patients were male. In a comparison with patients without recurrence, the authors found that relatively lower body mass index was significantly associated with recurrence (p = 0.005), such that LDH in nonobese patients was more likely to recur. Conclusions Recurrence rates following tLMD for LDH compare favorably with those in patients who have undergone open discectomy, lending further support for its effectiveness in treating single-level LDH. Nonobese patients with a relatively lower body mass index, in particular, appear to be at greater risk for recurrence.

scholarly journals Faktor Risiko Determinan Yang Konsisten Berhubungan dengan Kejadian Stunting Pada Anak Usia 6-24 Bulan: Tinjauan Pustaka

2020 ◽  
Vol 4 (2) ◽  
pp. 85
Author(s):  
Ratnawati Ratnawati ◽  
Mohammad Zen Rahfiludin
Keyword(s):  
Risk Factors ◽  
Search Engine ◽  
Family Income ◽  
Google Scholar ◽  
Family Welfare ◽  
Journal Articles ◽  
Income Family ◽  
Global Health Issue ◽  
Index Level ◽  
Welfare Index

Background : Stunting remains a global health issue with a prevalence of 21.9% in 2018. Many variables of stunting risk factors have been studied. Research results that show dominant risk factors that consistently affect stunting are needed as a priority for prevention.Objective: To determine the dominant risk factors that are consistently associated with stunting events.Methods: This systematic review was carried out using the Google Scholar search engine and Springerlink E-Journal using the keyword stunting of children aged 6-24 months.  Exclusion criteria were published >5 years, journals were not reputable on SCIMAGOJR and were referenced <10 times and has a sinta index > 2.Results: There were 3 international journal articles Q1 and 5 national journals accredited by Sinta 2. The number of variables studied in 8 journals is 51 Variables. There were 36 variables that were conducted only one study with significant results related to the incidence of stunting as many as 16 variables and 20 variables were not significant. The variables conducted by the research with inconsistent analysis results were 8 variables. Dominant variables that show a significant relationship with the incidence of stunting consistently from four different studies are low birth weight (LBW) and family income / family welfare index. The lowest & highest risk factors LBW (OR=3.26 & 5.870), Income / welfare index (OR=2.2 & 8.5). Protein Adequacy Level (OR=5.54 & 7.65) and children aged 12-24 months (AOR=2.688 & 3.24) were consistent in 2 studies.Conclusion: LBW, income / family welfare index, level of protein adequacy and children aged 12-24 months were variables with dominant and consistent stunting risk factors.ABSTRAKLatar Belakang : Stunting masih menjadi masalah kesehatan di dunia dengan prevalensi 21,9 % pada tahun 2018. Ada Banyak variabel faktor risiko stunting yang sudah diteliti. Penelurusan hasil penelitian yang menunjukkan faktor risiko dominan secara konsisten mempergaruhi stunting sangat diperlukan sebagai prioritas untuk pencegahan.Tujuan : Untuk mengidentifikasi  faktor risiko dominan yang secara konsisten bermakna hubungannya dengan kejadian stunting.Metode : Tinjauan pustaka ini dilakukan dengan mengunakan search engine google scholar dan springerlink E- Journal  mengunakan kata stunting usia 6-24 bulan. Kriteria esklusi terbit > 5 tahun terakhir, jurnal tidak bereputasi pada SCIMAGOJR dan dirujuk < 10 kali dan sinta > 2.Hasil Ulasan : Didapatkan 3 artikel jurnal internasional Q1 dan 5 jurnal nasional terakreditasi Sinta 2. Jumlah variabel yang diteliti pada 8 jurnal sebanyak 51 Variabel. Didapatkan 36 variabel yang dilakukan hanya satu kali penelitian dengan hasil yang signifikan berhubungan dengan kejadian stunting sebanyak 16 variabel dan 20 variabel tidak signifikan. Variabel yang dilakukan penelitian dengan hasil analisis yang tidak konsisten sebanyak 8 variabel. Variabel dominan yang menunjukkan hubungan bermakna dengan kejadian stunting secara konsisten dari empat penelitian yang berbeda adalah BBLR dan pendapatan keluarga/indeks kesejahteraan keluarga.  Faktor risiko yang terendah&tertinggi BBLR (OR=3,26 & 5,870), Pendapatan/Indeks kesejahteraan (OR=2,2&8,5).  Tingkat Kecukupan Protein (OR=5,54 & 7,65) dan usia anak 12-24 bulan (AOR =2,688 & 3,24) konsisten pada 2 penelitian.Kesimpulan BBLR, pendapatan /indeks kesejahteraan keluarga, tingkat kecukupan protein dan usia anak 12-24 bulan merupakan variabel dengan faktor risiko stunting yang dominan konsisten. 

scholarly journals A Nomogram for Preoperatively Predicting the Ki-67 Index of a Pituitary Tumor: A Retrospective Cohort Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiangming Cai ◽  
Junhao Zhu ◽  
Jin Yang ◽  
Chao Tang ◽  
Feng Yuan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Calibration Curve ◽  
Validation Cohort ◽  
Characteristic Curve ◽  
Treatment Strategies ◽  
Predictive Performance ◽  
Maximum Dimension ◽  
Ki 67 ◽  
Training Cohort ◽  
Index Level

BackgroundThe Ki-67 index is an indicator of proliferation and aggressive behavior in pituitary adenomas (PAs). This study aims to develop and validate a predictive nomogram for forecasting Ki-67 index levels preoperatively in PAs.MethodsA total of 439 patients with PAs underwent PA resection at the Department of Neurosurgery in Jinling Hospital between January 2018 and October 2020; they were enrolled in this retrospective study and were classified randomly into a training cohort (n = 300) and a validation cohort (n = 139). A range of clinical, radiological, and laboratory characteristics were collected. The Ki-67 index was classified into the low Ki-67 index (&lt;3%) and the high Ki-67 index (≥3%). Least absolute shrinkage and selection operator algorithm and uni- and multivariate logistic regression analyses were applied to identify independent risk factors associated with Ki-67. A nomogram was constructed to visualize these risk factors. The receiver operation characteristic curve and calibration curve were computed to evaluate the predictive performance of the nomogram model.ResultsAge, primary-recurrence subtype, maximum dimension, and prolactin were included in the nomogram model. The areas under the curve (AUCs) of the nomogram model were 0.694 in the training cohort and 0.658 in the validation cohort. A well-fitted calibration curve was also generated for the nomogram model. A subgroup analysis revealed stable predictive performance for the nomogram model. A correlation analysis revealed that age (R = −0.23; p &lt; 0.01), maximum dimension (R = 0.17; p &lt; 0.01), and prolactin (R = 0.16; p &lt; 0.01) were all significantly correlated with the Ki-67 index level.ConclusionsAge, primary-recurrence subtype, maximum dimension, and prolactin are independent predictors for the Ki-67 index level. The current study provides a novel and feasible nomogram, which can further assist neurosurgeons to develop better, more individualized treatment strategies for patients with PAs by predicting the Ki-67 index level preoperatively.

scholarly journals Trends in Women's Risk Factors and Chronic Conditions: Findings from the Australian Longitudinal Study on Women's Health

2007 ◽  
Vol 3 (4) ◽  
pp. 423-432 ◽  
Author(s):  
Jayne Lucke ◽  
Bree Waters ◽  
Richard Hockey ◽  
Melanie Spallek ◽  
Richard Gibson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Women’S Health ◽  
Women's Health ◽  
Chronic Conditions ◽  
Age Groups ◽  
Level Of Education ◽  
Australian Longitudinal Study ◽  
Index Level

Chronic diseases present a growing challenge to women's health. This paper presents data from the Australian Longitudinal Study on Women's Health to show prevalence and incidence among three cohorts of women of six chronic conditions: hypertension, heart disease, diabetes, asthma, osteoporosis and arthritis. It also examines the role of five important risk factors (body mass index, level of physical activity, smoking, alcohol consumption and level of education) on these chronic conditions. The most striking finding is that being overweight or obese is the most important risk factor for chronic disease for women in all three age groups.

scholarly journals Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia

2022 ◽  
Vol 2022 ◽  
pp. 1-9
Author(s):  
Jing Lei ◽  
Li Wang ◽  
Qian Li ◽  
Lin Gao ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Poor Prognosis ◽  
Total Bilirubin ◽  
Oxygenation Index ◽  
Severe Pneumonia ◽  
Albumin Level ◽  
Significant Decline ◽  
Survival Group ◽  
Index Level

Objective. To investigate efficiency of RAGE and OSM as new prognosis biomarkers of severe pneumonia. Methods. Eligible patients were classified into hypoxemia and nonhypoxemia groups. Meanwhile, the same cohort was divided into survival and nonsurvival groups after a post-hospital stay of 30 days. We analyzed risk factors for the hypoxia and death among these patients. Results. Compared with nonsurvival group, significant increase was noticed in PH, lymphocyte, albumin and platelet level in survival group, while significant decline was noticed in neutrophils, RBC, hemoglobin, hematocrit, creatinine, total bilirubin, CRP, PCT, OSM, RAGE and neutrophils/lymphocyte level. Oxygenation index level was related to APACHE II, LIS, SOFA, NUTRIC score, WBC, neutrophils, lymphocyte, RAGE, and albumin level ( p < 0.05 ). LIS, SOFA, NUTRIC score, lac, lymphocyte, platelet, BUN, total bilirubin, PCT, and OSM levels were associated with mortality rate ( p < 0.05 ). Conclusions. RAGE and OSM may serve as a new biomarker for poor prognosis in pneumonia patients.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

The Preschool Stuttering Screen for Health Care Professionals

2011 ◽  
Vol 21 (2) ◽  
pp. 59-62
Author(s):  
Joseph Donaher ◽  
Christina Deery ◽  
Sarah Vogel
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Differential Diagnosis ◽  
Preschool Children ◽  
Health Care Professionals ◽  
Healthcare Professionals ◽  
Evidence Based ◽  
Developmental Profile

Healthcare professionals require a thorough understanding of stuttering since they frequently play an important role in the identification and differential diagnosis of stuttering for preschool children. This paper introduces The Preschool Stuttering Screen for Healthcare Professionals (PSSHP) which highlights risk factors identified in the literature as being associated with persistent stuttering. By integrating the results of the checklist with a child’s developmental profile, healthcare professionals can make better-informed, evidence-based decisions for their patients.

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