New biaryl-chalcone derivatives of pregnenolone via Suzuki–Miyaura cross-coupling reaction. Synthesis, CYP17 hydroxylase inhibition activity, QSAR, and molecular docking study

Steroids ◽  
2015 ◽  
Vol 101 ◽  
pp. 43-50 ◽  
Author(s):  
Najim A. Al-Masoudi ◽  
Rawaa A. Kadhim ◽  
Nabeel A. Abdul-Rida ◽  
Bahjat A. Saeed ◽  
Matthias Engel
Keyword(s):  
Molecular Docking ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Docking Study ◽  
Reaction Synthesis ◽  
Inhibition Activity ◽  
Molecular Docking Study ◽  
Chalcone Derivatives ◽  
Cross Coupling Reaction ◽  
Derivatives Of

scholarly journals Synthesis of 4-Alkyl-4H-1,2,4-triazole Derivatives by Suzuki Cross-coupling Reactions and Their Luminescence Properties

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 652 ◽  
Author(s):  
Monika Olesiejuk ◽  
Agnieszka Kudelko ◽  
Marcin Swiatkowski ◽  
Rafal Kruszynski
Keyword(s):  
Ionic Liquids ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Luminescence Properties ◽  
Coupling Reactions ◽  
Triazole Derivatives ◽  
Cross Coupling Reactions ◽  
Cross Coupling Reaction ◽  
Derivatives Of

New derivatives of 4-alkyl-3,5-diaryl-4H-1,2,4-triazole were synthesized utilizing the Suzuki cross-coupling reaction. The presented methodology comprises of the preparation of bromine-containing 4-alkyl-4H-1,2,4-triazoles and their coupling with different commercially available boronic acids in the presence of ionic liquids or in conventional solvents. The obtained compounds were tested for their luminescence properties.

Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study

2018 ◽  
Vol 78 ◽  
pp. 210-219 ◽  
Author(s):  
M. Antonela Zígolo ◽  
Maximiliano Salinas ◽  
Laura Alché ◽  
Alicia Baldessari ◽  
Guadalupe García Liñares
Keyword(s):  
Molecular Docking ◽  
Antiviral Activity ◽  
Docking Study ◽  
Glycyrrhetinic Acid ◽  
Chemoenzymatic Synthesis ◽  
Molecular Docking Study ◽  
Derivatives Of

New phosphate derivatives of betulin as anticancer agents: Synthesis, crystal structure, and molecular docking study

2019 ◽  
Vol 87 ◽  
pp. 613-628 ◽  
Author(s):  
Elwira Chrobak ◽  
Monika Kadela-Tomanek ◽  
Ewa Bębenek ◽  
Krzysztof Marciniec ◽  
Joanna Wietrzyk ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Docking ◽  
Anticancer Agents ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Derivatives Of

Palladium-Catalyzed Regioselective Heck–Suzuki–Miyaura Cascade Cyclization for the Synthesis of Trisubstituted Arylideneisoquinolinones

Synlett ◽  
2019 ◽  
Vol 30 (09) ◽  
pp. 1073-1076 ◽  
Author(s):  
M. Asgari ◽  
R. Mirzazadeh ◽  
B. Larijani ◽  
P. Rashidi Ranjbar ◽  
R. Rahimi ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Cascade Cyclization ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Derivatives Of

An Ugi four-component reaction was used to construct propargylamide starting materials for a subsequent domino Heck–Suzuki–Miyaura cross-coupling reaction to give derivatives of 4-benzylidene-1-oxo-3,4-dihydro-1H-isoquinoline.

scholarly journals Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (–)-Pentenomycin I

Synlett ◽  
2020 ◽  
Vol 31 (05) ◽  
pp. 475-481
Author(s):  
Stavroula A. Zisopoulou ◽  
Spyridon Bousis ◽  
Jörg Haupenthal ◽  
Jennifer Herrmann ◽  
Rolf Müller ◽  
...  
Keyword(s):  
Natural Product ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Eukaryotic Cell ◽  
Biological Evaluation ◽  
Gram Positive Bacteria ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A library of novel 2-substituted derivatives of the antibiotic natural product pentenomycin I is presented. The new collection of analogues is divided in two main classes, 2-alkynyl- and 2-aryl- derivatives, which are accessed by the appropriate type of palladium-catalyzed cross-coupling reaction of the 2-iodo-protected pentenomycin I with suitable nucleophiles. The new derivatives were tested for their activity against certain types of bacteria and one of them, compound 8h, was found to exhibit significant inhibitory activity against several Gram-positive bacteria but also displayed cytotoxic activity against eukaryotic cell lines.

Synthesis of novel organohalogen chalcone derivatives and screening of their molecular docking study and some enzymes inhibition effects

2020 ◽  
Vol 1208 ◽  
pp. 127868 ◽  
Author(s):  
Serdar Burmaoglu ◽  
Elif Akin Kazancioglu ◽  
Ruya Kaya ◽  
Mustafa Kazancioglu ◽  
Muhammet Karaman ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Chalcone Derivatives ◽  
Enzymes Inhibition

scholarly journals Synthesis and antifungal properties of papulacandin derivatives

2012 ◽  
Vol 8 ◽  
pp. 732-737 ◽  
Author(s):  
Marjolein van der Kaaden ◽  
Eefjan Breukink ◽  
Roland J Pieters
Keyword(s):  
Biological Activity ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Side Chain ◽  
Aryl Iodide ◽  
Glucan Synthase ◽  
Cross Coupling Reaction ◽  
Acyl Side Chain ◽  
Palladium Catalyzed ◽  
Derivatives Of

Derivatives of an antifungal agent that targets the β-(1,3)-D-glucan synthase, papulacandin D, were synthesized and tested for activity. The papulacandin D structure contains a challenging benzannulated spiroketal unit, which is introduced in a palladium-catalyzed cross-coupling reaction of a glycal silanolate and an aryl iodide followed by an oxidative spiroketalization. Four different variants were made, differing in the nature of the acyl side chain with respect to the length, and in the number and stereochemistry of the double bonds. Moderate biological activity was observed for the derivatives with a side chain based on palmitic acid and linoleic acid.

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