Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial

Surgery ◽  
2014 ◽  
Vol 155 (3) ◽  
pp. 493-503 ◽  
Author(s):  
Sotaro Sadahiro ◽  
Toshiyuki Suzuki ◽  
Akira Tanaka ◽  
Kazutake Okada ◽  
Hiroko Kamata ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Randomized Trial ◽  
Bowel Preparation ◽  
Cancer Surgery ◽  
Prospective Randomized Trial ◽  
Oral Antibiotics ◽  
Colon Cancer Surgery ◽  
Elective Colon

scholarly journals Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery

2012 ◽  
Vol 35 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Keiichiro Ishibashi ◽  
Kensuke Kumamoto ◽  
Kouki Kuwabara ◽  
Naoko Hokama ◽  
Toru Ishiguro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Bowel Preparation ◽  
Mechanical Bowel Preparation ◽  
Cancer Surgery ◽  
Colon Cancer Surgery ◽  
Elective Colon

scholarly journals Multicenter phase III randomized trial comparing laparoscopy and laparotomy for colon cancer surgery in patients older than 75 years: the CELL study, a Fédération de Recherche en Chirurgie (FRENCH) trial

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Gilles Manceau ◽  
Antoine Brouquet ◽  
Pascal Chaibi ◽  
Guillaume Passot ◽  
Olivier Bouché ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Elderly Patients ◽  
Randomized Trial ◽  
Postoperative Morbidity ◽  
The Elderly ◽  
Cancer Surgery ◽  
Phase Iii ◽  
Randomized Controlled ◽  
Colon Cancer Surgery

Abstract Background Several multicenter randomized controlled trials comparing laparoscopy and conventional open surgery for colon cancer have demonstrated that laparoscopic approach achieved the same oncological results while improving significantly early postoperative outcomes. These trials included few elderly patients, with a median age not exceeding 71 years. However, colon cancer is a disease of the elderly. More than 65% of patients operated on for colon cancer belong to this age group, and this proportion may become more pronounced in the coming years. In current practice, laparoscopy is underused in this population. Methods The CELL (Colectomy for cancer in the Elderly by Laparoscopy or Laparotomy) trial is a multicenter, open-label randomized, 2-arm phase III superiority trial. Patients aged 75 years or older with uncomplicated colonic adenocarcinoma or endoscopically unresectable colonic polyp will be randomized to either colectomy by laparoscopy or laparotomy. The primary endpoint of the study is overall postoperative morbidity, defined as any complication classification occurring up to 30 days after surgery. The secondary endpoints are: 30-day and 90-day postoperative mortality, 30-day readmission rate, quality of surgical resection, health-related quality of life and evolution of geriatric assessment. A 35 to 20% overall postoperative morbidity rate reduction is expected for patients operated on by laparoscopy compared with those who underwent surgery by laparotomy. With a two-sided α risk of 5% and a power of 80% (β = 0.20), 276 patients will be required in total. Discussion To date, no dedicated randomized controlled trial has been conducted to evaluate morbidity after colon cancer surgery by laparoscopy or laparotomy in the elderly and the benefits of laparoscopy is still debated in this context. Thus, a prospective multicenter randomized trial evaluating postoperative outcomes specifically in elderly patients operated on for colon cancer by laparoscopy or laparotomy with curative intent is warranted. If significant, such a study might change the current surgical practices and allow a significant improvement in the surgical management of this population, which will be the vast majority of patients treated for colon cancer in the coming years. Trial registration ClinicalTrials.gov NCT03033719 (January 27, 2017).

Effects of beta-blocker therapy on mortality after elective colon cancer surgery

2019 ◽  
Vol 31 ◽  
pp. 108
Author(s):  
R. Ahl ◽  
P. Matthiessen ◽  
G. Sjolin ◽  
Y. Cao ◽  
O. Ljungqvist ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Beta Blocker ◽  
Cancer Surgery ◽  
Blocker Therapy ◽  
Beta Blocker Therapy ◽  
Colon Cancer Surgery ◽  
Elective Colon

Effects of early beta-blockade on morbidity and mortality outcomes after elective colon cancer surgery

2018 ◽  
Vol 25 ◽  
pp. 196-197
Author(s):  
Rebecka Ahl ◽  
Peter Matthiessen ◽  
Xin Fang ◽  
Yang Cao ◽  
Göran Wallin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Surgery ◽  
Morbidity And Mortality ◽  
Beta Blockade ◽  
Colon Cancer Surgery ◽  
Elective Colon

scholarly journals Long‐term survival following elective colon cancer surgery in the aged. A population‐based cohort study

2020 ◽  
Vol 22 (11) ◽  
pp. 1585-1596
Author(s):  
S. Niemeläinen ◽  
H. Huhtala ◽  
A. Ehrlich ◽  
J. Kössi ◽  
E. Jämsen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Population Based ◽  
Cancer Surgery ◽  
Term Survival ◽  
Long Term Survival ◽  
Colon Cancer Surgery ◽  
Elective Colon

Usefulness of Preoperative Mechanical Bowel Preparation in Patients with Colon Cancer who Undergo Elective Surgery: A Prospective Randomized Trial Using Oral Antibiotics

2019 ◽  
Vol 37 (3) ◽  
pp. 192-198 ◽  
Author(s):  
Toshiyuki Suzuki ◽  
Sotaro Sadahiro ◽  
Akira Tanaka ◽  
Kazutake Okada ◽  
Gota Saito ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Bowel Preparation ◽  
Elective Surgery ◽  
Mechanical Bowel Preparation ◽  
Infectious Complications ◽  
Oral Antibiotic ◽  
Oral Antibiotics ◽  
Intravenous Antibiotics ◽  
Colon Cancer Surgery ◽  
To Receive

Background: To prevent surgical site infection (SSI) in colorectal surgery, the combination of mechanical bowel preparation (MBP), oral antibiotic bowel preparation (OABP), and the intravenous antibiotics have been proposed as standard treatment. We conducted an RCT comparing the incidence of SSI between MBP + OABP and OABP alone after receiving a single dose of intravenous antibiotics. Methods: The study group comprised 254 patients who underwent elective surgery for colon cancer. Patients were randomly assigned to receive MBP + OABP and intravenous antibiotics (MBP + OABP group) or to receive OABP and intravenous antibiotics (OABP alone group). Results: Overall, 125 patients in MBP + OABP group and 126 patients in OABP alone group were eligible. Incisional SSI occurred in 3 patients (2.4%) in MBP + OABP group, and 8 patients (6.3%) in the OABP-alone group. Organ/space SSI developed in 0 patients (0%) and in 4 patients (3.2%) in each group respectively. The OABP-alone group was thus not shown to be noninferior to the MBP + OABP group in the incidences of incisional SSI or organ/space SSI. Other infectious complications developed in 7 patients (5.6%) and in 6 patients (4.8%) in each group, indicating the non-inferiority of OABP alone to MBP + OABP. Conclusions: MBP combined with oral antibiotics and intravenous antibiotics remains standard in elective colon cancer surgery.

scholarly journals Complete state-wide outcomes in elective colon cancer surgery

2018 ◽  
Vol 88 (11) ◽  
pp. 1174-1177 ◽  
Author(s):  
Ian G. Faragher ◽  
Michael K.-Y. Hong ◽  
Douglas Stupart ◽  
David A. Watters ◽  
Justin Yeung
Keyword(s):  
Colon Cancer ◽  
Cancer Surgery ◽  
Complete State ◽  
Colon Cancer Surgery ◽  
Elective Colon

scholarly journals Risk factors of short-term survival in the aged in elective colon cancer surgery: a population-based study

2019 ◽  
Vol 35 (2) ◽  
pp. 307-315 ◽  
Author(s):  
Susanna Niemeläinen ◽  
Heini Huhtala ◽  
Anu Ehrlich ◽  
Jyrki Kössi ◽  
Esa Jämsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colon Cancer ◽  
Postoperative Complications ◽  
Population Based ◽  
Cancer Surgery ◽  
Mortality Data ◽  
Short Term ◽  
Population Based Study ◽  
Colon Cancer Surgery ◽  
Elective Colon

Abstract Purpose Patients aged > 80 years represent an increasing proportion of colon cancer diagnoses. Selecting patients for elective surgery is challenging because of possibly compromised health status and functional decline. The aim of this retrospective, population-based study was to identify risk factors and health measures that predict short-term mortality after elective colon cancer surgery in the aged. Methods All patients > 80 years operated electively for stages I–III colon cancer from 2005 to 2016 in four Finnish hospitals were included. The prospectively collected data included comorbidities, functional status, postoperative surgical and medical outcomes as well as mortality data. Results A total of 386 patients (mean 84.0 years, range 80–96, 56% female) were included. Male gender (46% vs 35%, p = 0.03), higher BMI (51% vs 37%, p = 0.02), diabetes mellitus (51% vs 37%, p = 0.02), coronary artery disease (52% vs 36%, p = 0.003) and rheumatic diseases (67% vs 39%, p = 0.03) were related to higher risk of complications. The severe complications were more common in patients with increased preoperative hospitalizations (31% vs 15%, p = 0.05) and who lived in nursing homes (30% vs 17%, p = 0.05). The 30-day and 1-year mortality rates were 6.0% and 15% for all the patients compared with 30% and 45% in patients with severe postoperative complications (p < 0.001). Severe postoperative complications were the only significant patient-related variable affecting 1-year mortality (OR 9.60, 95% CI 2.33–39.55, p = 0.002). Conclusions The ability to identify preoperatively patients at high risk of decreased survival and thus prevent severe postoperative complications could improve overall outcome of aged colon cancer patients.

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