The mammalian pineal gland: known facts, unknown facets

2007 ◽  
Vol 18 (4) ◽  
pp. 142-149 ◽  
Author(s):  
Erik Maronde ◽  
Jörg H. Stehle
Keyword(s):  
Pineal Gland ◽  
Mammalian Pineal Gland

scholarly journals Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205883 ◽  
Author(s):  
Joseph C. Mays ◽  
Michael C. Kelly ◽  
Steven L. Coon ◽  
Lynne Holtzclaw ◽  
Martin F. Rath ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Single Cell ◽  
Rna Sequencing ◽  
Cell Type ◽  
Single Cell Rna Sequencing ◽  
Cell Type Specific ◽  
Mammalian Pineal Gland ◽  
Daily Patterns

Morphofunctional aspects of the mammalian pineal gland

1992 ◽  
Vol 21 (2) ◽  
pp. 136-157 ◽  
Author(s):  
Michal Karasek ◽  
Russel J. Reiter
Keyword(s):  
Pineal Gland ◽  
Mammalian Pineal Gland

Melatonin: That Ubiquitously Acting Pineal Hormone

Physiology ◽  
1991 ◽  
Vol 6 (5) ◽  
pp. 223-227 ◽  
Author(s):  
RJ Reiter
Keyword(s):  
Pineal Gland ◽  
Cell Membranes ◽  
Physiological Activity ◽  
Mammalian Pineal Gland

Circadian production and secretion of melatonin from mammalian pineal gland provides animals with information concerning the light/dark environment. Melatonin passes easily through cell membranes;thus each organ, provided it can interpret the melatonin message, can adjust its physiological activity accordingly.

The chemical neuroanatomy of the mammalian pineal gland: Neuropeptides

1996 ◽  
Vol 28 (1) ◽  
pp. 23-33 ◽  
Author(s):  
M. Møller ◽  
J.-P. Ravault ◽  
Bruno Cozzi
Keyword(s):  
Pineal Gland ◽  
Mammalian Pineal Gland ◽  
Chemical Neuroanatomy

Neuropeptide Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland

2015 ◽  
Vol 18 (1) ◽  
pp. 53-61 ◽  
Author(s):  
N. Ziółkowska ◽  
B. Lewczuk ◽  
B. Przybylska-Gornowicz
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Adrenergic Nerve ◽  
Sympathetic Nerve Fibers ◽  
Uk 14,304 ◽  
Mammalian Pineal Gland ◽  
Pharmacologically Active

Abstract Norepinephrine (NE) released from the sympathetic nerve endings is the main neurotransmitter controlling melatonin synthesis in the mammalian pineal gland. Although neuropeptide Y (NPY) co-exists with NE in the pineal sympathetic nerve fibers it also occurs in a population of non-adrenergic nerve fibers located in this gland. The role of NPY in pineal physiology is still enigmatic. The present study characterizes the effect of NPY on the depolarization-evoked 3H-NE release from the pig pineal explants. The explants of the pig pineal gland were loaded with 3H-NE in the presence of pargyline and superfused with Tyrode medium. They were exposed twice to the modified Tyrode medium containing 60 mM of K+ to evoke the 3H-NE release via depolarization. NPY, specific agonists of Y1- and Y2-receptors and pharmacologically active ligands of α2-adrenoceptors were added to the medium before and during the second depolarization. The radioactivity was measured in medium fractions collected every 2 minutes during the superfusion. NPY (0.1 – 10 μM) significantly decreased the depolarization-induced 3H-NE release. Similar effect was observed after the treatment with Y2-agonist: NPY13-36, but not with Y1-agonist: [Leu31, Pro34]-NPY. The tritium overflow was lower in the explants exposed to the 5 μM NPY and 1 μM rauwolscine than to rauwolscine only. The effects of 5 μM NPY and 0.05 μM UK 14,304 on the depolarization-evoked 3H-NE release were additive. The results show that NPY is involved in the regulation of NE release from the sympathetic terminals in the pig pineal gland, inhibiting this process via Y2-receptors.

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