Synthesis of α,α-disubstituted amino acids based on tandem reaction of dehydroamino acid derivatives

Tetrahedron ◽  
2005 ◽  
Vol 61 (2) ◽  
pp. 385-393 ◽  
Author(s):  
Hideto Miyabe ◽  
Ryuta Asada ◽  
Yoshiji Takemoto
Keyword(s):  
Amino Acids ◽  
Tandem Reaction ◽  
Dehydroamino Acid ◽  
Disubstituted Amino Acids

Nickel-catalyzed carbodifunctionalization of N-vinylamides enables access to γ-amino acids

2020 ◽  
Vol 56 (17) ◽  
pp. 2642-2645 ◽  
Author(s):  
Zhi-Fang Yang ◽  
Chang Xu ◽  
Xing Zheng ◽  
Xingang Zhang
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Tandem Reaction ◽  
Amino Acid Esters ◽  
Arylboronic Acids ◽  
Acid Esters

A nickel-catalyzed tandem reaction of N-vinylamides with arylboronic acids and bromodifluoroacetate has been developed. The reaction efficiently furnishes a series of protected α,α-difluoro-γ-amino acid esters.

Synthesis of a series of “cationic”, orthogonally protected, α, α-disubstituted amino acids

2005 ◽  
pp. 329-330
Author(s):  
T. S. Yokum ◽  
M. G. Bursavich ◽  
S. A. Piha-Paul ◽  
D. A. Hall ◽  
M. L. McLaughlin
Keyword(s):  
Amino Acids ◽  
Disubstituted Amino Acids

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters

2017 ◽  
Vol 25 (6) ◽  
pp. 1846-1851 ◽  
Author(s):  
Hiroko Yamashita ◽  
Takashi Misawa ◽  
Makoto Oba ◽  
Masakazu Tanaka ◽  
Mikihiko Naito ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Disubstituted Amino Acids
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