scholarly journals Synthetic approaches and total syntheses of vinigrol, a unique diterpenoid

Tetrahedron ◽  
2015 ◽  
Vol 71 (23) ◽  
pp. 3775-3793 ◽  
Author(s):  
Cristian Draghici ◽  
Jon T. Njardarson
Keyword(s):  
Total Syntheses ◽  
Synthetic Approaches

Recent Advances in the Total Synthesis of Clavaminols

Synthesis ◽  
2018 ◽  
Vol 50 (23) ◽  
pp. 4569-4576
Author(s):  
Tian Jin ◽  
Lu Zhao ◽  
Zhe-Bin Zheng ◽  
Xiao Liu ◽  
Liang Sun ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Research Groups ◽  
Total Syntheses ◽  
New Class ◽  
Recent Advances ◽  
Molecular Architectures ◽  
Synthetic Approaches ◽  
Long Chain

Clavaminols are a new class of long-chain 2-amino-3-­alkanols that mostly contain 2R,3S-configurations. Owing to their interesting molecular architectures and promising activities, they have ­become popular targets for synthetic organic chemists. In this review, we highlight 12 total syntheses of clavaminols from different research groups during the period 2009 to 2018.1 Introduction2 Synthetic Approaches toward Clavaminols2.1 Total Synthesis by Chemla and Colleagues (2009)2.2 Total Synthesis by Greck and Colleagues (2010)2.3 Total Synthesis by Sutherland and Zaed (2011)2.4 Total Synthesis by Huang and Colleagues (2011)2.5 Total Synthesis by Kotora and Colleagues (2012)2.6 Total Synthesis by Kumar and Colleagues (2013)2.7 Total Synthesis by Prabhavathi Devi and Colleagues (2013 and 2016)2.8 Total Synthesis by Sarabia and Colleagues (2014)2.9 Total Synthesis by Mohapatra and Colleagues (2016)2.10 Total Synthesis by Lu and Colleagues (2016)2.11 Total Synthesis by Jin and Colleagues (2017)2.12 Total Synthesis by Kumar Pandey and Colleagues (2018)3 Conclusion

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

ChemInform Abstract: Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

ChemInform ◽  
2013 ◽  
Vol 44 (41) ◽  
pp. no-no
Author(s):  
Phillip D. Bass ◽  
Daniel A. Gubler ◽  
Ted C. Judd ◽  
Robert M. Williams
Keyword(s):  
Mechanism Of Action ◽  
Total Syntheses ◽  
Synthetic Approaches

Concise Synthetic Approaches for the Laurencia Family: Formal Total Syntheses of (±)-Laurefucin and (±)-E- and (±)-Z-Pinnatifidenyne

2012 ◽  
Vol 134 (42) ◽  
pp. 17714-17721 ◽  
Author(s):  
Scott A. Snyder ◽  
Alexandria P. Brucks ◽  
Daniel S. Treitler ◽  
Ioana Moga
Keyword(s):  
Total Syntheses ◽  
Synthetic Approaches

Studies Towards the Synthesis of (+)- and (–)-Anisomycin and Their Analogues

Synthesis ◽  
2017 ◽  
Vol 50 (01) ◽  
pp. 17-34 ◽  
Author(s):  
Arun Shaw ◽  
Sama Ajay
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Present Review ◽  
Formal Synthesis ◽  
Total Syntheses ◽  
Synthetic Approaches

Anisomycin shows potent biological activity and it has attracted much attention since its isolation in 1954, with around 13 total syntheses and 20 formal syntheses, and also two reports concerning analogues of anisomycin, reported to date. The present review highlights all of these synthetic approaches (around 35) to the total or formal synthesis of anisomycin along with its isomers and analogues.1 Introduction2 Isolation and Therapeutic Importance3 Total Synthesis of (+)-, (–)-, and (±)-Anisomycins and Their Analogues4 Formal Synthesis of (+)- and (–)-Anisomycins and Their Analogues5 Conclusion

scholarly journals Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

2013 ◽  
Vol 113 (8) ◽  
pp. 6816-6863 ◽  
Author(s):  
Phillip D. Bass ◽  
Daniel A. Gubler ◽  
Ted C. Judd ◽  
Robert M. Williams
Keyword(s):  
Mechanism Of Action ◽  
Total Syntheses ◽  
Synthetic Approaches

scholarly journals (Semi)-Synthetic Fucosylated Chondroitin Sulfate Oligo- and Polysaccharides

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 293
Author(s):  
Giulia Vessella ◽  
Serena Traboni ◽  
Antonio Laezza ◽  
Alfonso Iadonisi ◽  
Emiliano Bedini
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Anticoagulant Activity ◽  
Structural Heterogeneity ◽  
Low Molecular Weight ◽  
Total Syntheses ◽  
Multiple Copies ◽  
Synthetic Approaches ◽  
First Time ◽  
Made In

Fucosylated chondroitin sulfate (fCS) is a glycosaminoglycan (GAG) polysaccharide with a unique structure, displaying a backbone composed of alternating N-acetyl-d-galactosamine (GalNAc) and d-glucuronic acid (GlcA) units on which l-fucose (Fuc) branches are installed. fCS shows several potential biomedical applications, with the anticoagulant activity standing as the most promising and widely investigated one. Natural fCS polysaccharides extracted from marine organisms (Echinoidea, Holothuroidea) present some advantages over a largely employed antithrombotic drug such as heparin, but some adverse effects as well as a frequently found structural heterogeneity hamper its development as a new drug. To circumvent these drawbacks, several efforts have been made in the last decade to obtain synthetic and semi-synthetic fCS oligosaccharides and low molecular weight polysaccharides. In this Review we have for the first time collected these reports together, dividing them in two topics: (i) total syntheses of fCS oligosaccharides and (ii) semi-synthetic approaches to fCS oligosaccharides and low molecular weight polysaccharides as well as glycoclusters displaying multiple copies of fCS species.

The Chemical Syntheses of Nannocystins

Synthesis ◽  
2019 ◽  
Vol 51 (11) ◽  
pp. 2252-2260
Author(s):  
Zhang Wang
Keyword(s):  
Natural Products ◽  
Anticancer Activity ◽  
Short Review ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Total Syntheses ◽  
Sar Studies ◽  
Structure Activity ◽  
Synthetic Approaches

The broad and potent anticancer activity of the nannocystin family of natural products has attracted significant efforts toward their total syntheses. Currently, seven total syntheses of different members of the nannocystins have been reported. In this Short Review, different synthetic approaches are highlighted. The reported structure-activity relationship (SAR) studies will also be highlighted.

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