Inhibition of advanced glycation endproduct (AGE) rescues against streptozotocin-induced diabetic cardiomyopathy: Role of autophagy and ER stress

2018 ◽  
Vol 284 ◽  
pp. 10-20 ◽  
Author(s):  
Zhaohui Pei ◽  
Qinqin Deng ◽  
Sara A. Babcock ◽  
Emily Y. He ◽  
Jun Ren ◽  
...  
Keyword(s):  
Er Stress ◽  
Diabetic Cardiomyopathy ◽  
Advanced Glycation ◽  
Advanced Glycation Endproduct

scholarly journals Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Jiancheng Xu ◽  
Qi Zhou ◽  
Wei Xu ◽  
Lu Cai
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Er Stress ◽  
Diabetic Cardiomyopathy ◽  
Molecular Mechanisms ◽  
Critical Role ◽  
Lipid Synthesis ◽  
The Unfolded Protein Response ◽  
Cell Stress Response

The endoplasmic reticulum (ER) is an organelle entrusted with lipid synthesis, calcium homeostasis, protein folding, and maturation. Perturbation of ER-associated functions results in an evolutionarily conserved cell stress response, the unfolded protein response (UPR) that is also called ER stress. ER stress is aimed initially at compensating for damage but can eventually trigger cell death if ER stress is excessive or prolonged. Now the ER stress has been associated with numerous diseases. For instance, our recent studies have demonstrated the important role of ER stress in diabetes-induced cardiac cell death. It is known that apoptosis has been considered to play a critical role in diabetic cardiomyopathy. Therefore, this paper will summarize the information from the literature and our own studies to focus on the pathological role of ER stress in the development of diabetic cardiomyopathy. Improved understanding of the molecular mechanisms underlying UPR activation and ER-initiated apoptosis in diabetic cardiomyopathy will provide us with new targets for drug discovery and therapeutic intervention.

The role of ER stress for the pathogenesis of SCA3 in primary cell culture experiment

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
C Funke ◽  
J Hübener ◽  
H Wolburg ◽  
T Schmidt ◽  
H Toresson ◽  
...  
Keyword(s):  
Cell Culture ◽  
Er Stress ◽  
Primary Cell Culture ◽  
Primary Cell ◽  
Culture Experiment ◽  
Cell Culture Experiment
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