Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model

2021 ◽  
Author(s):  
Ramazan Kahveci ◽  
Fatih Ozan Kahveci ◽  
Emre Cemal Gokce ◽  
Aysun Gokce ◽  
Üçler Kısa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ganoderma Lucidum ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Ultrastructural Analysis ◽  
Ganoderma Lucidum Polysaccharides

Aged Garlic Extract Attenuates Neuronal Injury in a Rat Model of Spinal Cord Ischemia/Reperfusion Injury

2016 ◽  
Vol 19 (6) ◽  
pp. 601-606 ◽  
Author(s):  
Berker Cemil ◽  
Emre Cemal Gokce ◽  
Ramazan Kahveci ◽  
Aysun Gokce ◽  
Nurkan Aksoy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuronal Injury ◽  
Garlic Extract ◽  
Aged Garlic Extract ◽  
Aged Garlic

Modulation of the neurological and vascular complications by grape seed extract in a rat model of spinal cord ischemia–reperfusion injury by downregulation of both osteopontin and cyclooxygenase-2

2016 ◽  
Vol 94 (7) ◽  
pp. 719-727 ◽  
Author(s):  
Hussein F. Sakr ◽  
Amr M. Abbas ◽  
Ismaeel Bin-Jaliah
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Cox 2

In this study, we investigated the effects of grape seed extract (GSE) on the expression of osteopontin (OPN) and cyclooxygenase-2 (COX-2) in a rat model of spinal cord ischemia–reperfusion injury (SC-IRI). Fifty male rats were divided into 5 groups: control (CON); control + GSE (CON + GSE) (received GSE for 28 days); sham operated (Sham); IRI; and IRI + GSE. SC-IRI was induced by clamping the aorta just above the bifurcation for 45 min, and then the clamp was released for 48 h for reperfusion. IRI + GSE group received GSE for 28 days before SC-IRI. Sensory, motor, and placing/stepping reflex assessment was performed. Prostaglandin E2 (PGE2), thiobarbituric acid reactive substances (TBARs), and total antioxidant capacity (TAC) were measured in spinal cord homogenate. Immunohistochemical examination of the spinal cord for OPN and COX-2 were carried out. SC-IRI resulted in significant increase in plasma nitrite/nitrate level and spinal cord homogenate levels of TBARs and PGE2, and OPN and COX-2 expression with significant decrease in TAC. GSE improves the sensory and motor functions through decreasing OPN and COX-2 expression with reduction of oxidative stress parameters. We conclude a neuroprotective effect of GSE in SC-IRI through downregulating COX-2 and OPN expression plus its antioxidants effects.

scholarly journals Protective effects of Naringin in a rat model of spinal cord ischemia–reperfusion injury

2017 ◽  
Vol 16 (3) ◽  
pp. 649
Author(s):  
Yongsheng Cui ◽  
Wei Zhao ◽  
Xinhua Wang ◽  
Mingxin Chen ◽  
Li Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Protective Effects

The expression of bradykinin and its receptors in spinal cord ischemia-reperfusion injury rat model

Life Sciences ◽  
2019 ◽  
Vol 218 ◽  
pp. 340-345 ◽  
Author(s):  
Zheng Ma ◽  
Quan Dong ◽  
Boqiang Lyu ◽  
Jubo Wang ◽  
Yu Quan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia

scholarly journals Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury

2011 ◽  
Vol 54 (1) ◽  
pp. 192-200 ◽  
Author(s):  
Lihong Fan ◽  
Kunzheng Wang ◽  
Zhibin Shi ◽  
Jun Die ◽  
Chunsheng Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia
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