The catalytic subunit of DNA polymerase δ is a nucleocytoplasmic shuttling protein

2019 ◽  
Vol 375 (2) ◽  
pp. 36-40 ◽  
Author(s):  
Yuehong Shen ◽  
Kexin Wang ◽  
Robert Z. Qi
Keyword(s):  
Dna Polymerase ◽  
Catalytic Subunit ◽  
Nucleocytoplasmic Shuttling ◽  
Dna Polymerase Δ

PCNA and DNA Polymerase δ Catalytic Subunit fromSchizosaccharomyces pombeDo Not Interact Directly

1997 ◽  
Vol 231 (2) ◽  
pp. 321-328 ◽  
Author(s):  
Isabelle Tratner ◽  
Karine Piard ◽  
Muriel Grenon ◽  
Mylène Perderiset ◽  
Giuseppe Baldacci
Keyword(s):  
Dna Polymerase ◽  
Catalytic Subunit ◽  
Dna Polymerase Δ

scholarly journals Interaction of the retinoblastoma protein (pRb) with the catalytic subunit of DNA polymerase δ (p125)

Oncogene ◽  
2000 ◽  
Vol 19 (48) ◽  
pp. 5464-5470 ◽  
Author(s):  
Nancy A Krucher ◽  
Adam Zygmunt ◽  
Nayef Mazloum ◽  
Sama Tamrakar ◽  
John W Ludlow ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Retinoblastoma Protein ◽  
Catalytic Subunit ◽  
Dna Polymerase Δ

Structure of the Gene for the Catalytic Subunit of Human DNA Polymerase δ (POLD1)

Genomics ◽  
1995 ◽  
Vol 28 (3) ◽  
pp. 411-419 ◽  
Author(s):  
Long-Sheng Chang ◽  
Lingyun Zhao ◽  
Lingyun Zhu ◽  
Meei-Ling Chen ◽  
Marietta Y.W.T. Lee
Keyword(s):  
Dna Polymerase ◽  
Catalytic Subunit ◽  
Dna Polymerase Δ ◽  
Human Dna

scholarly journals Expression of the Catalytic Subunit of Human DNA Polymerase δ in Mammalian Cells Using a Vaccinia Virus Vector System

1995 ◽  
Vol 270 (14) ◽  
pp. 7993-7998 ◽  
Author(s):  
Peng Zhang ◽  
Isabelle Frugulhetti ◽  
Yunquan Jiang ◽  
Geraldine L. Holt ◽  
Richard C. Condit ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Dna Polymerase ◽  
Mammalian Cells ◽  
Virus Vector ◽  
Catalytic Subunit ◽  
Vector System ◽  
Dna Polymerase Δ ◽  
Human Dna ◽  
Vaccinia Virus Vector

scholarly journals The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yuehong Shen ◽  
Pengfei Liu ◽  
Taolue Jiang ◽  
Yu Hu ◽  
Franco K. C. Au ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Catalytic Subunit ◽  
Dna Polymerase Δ

scholarly journals Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase δ

1992 ◽  
Vol 20 (4) ◽  
pp. 735-745 ◽  
Author(s):  
Chun-Li Yang ◽  
Long-Sheng Chang ◽  
Peng Zhang ◽  
Huiling Hao ◽  
Lingyun Zhu ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Dna Polymerase ◽  
Catalytic Subunit ◽  
Dna Polymerase Δ ◽  
Human Dna

scholarly journals Reduced Levels of DNA Polymerase δ Induce Chromosome Fragile Site Instability in Yeast

2008 ◽  
Vol 28 (17) ◽  
pp. 5359-5368 ◽  
Author(s):  
Francene J. Lemoine ◽  
Natasha P. Degtyareva ◽  
Robert J. Kokoska ◽  
Thomas D. Petes
Keyword(s):  
Dna Polymerase ◽  
Cancer Biology ◽  
Molecular Mechanisms ◽  
Fragile Site ◽  
Fragile Sites ◽  
Dna Lesions ◽  
Catalytic Subunit ◽  
Dna Breaks ◽  
Dna Polymerase Δ ◽  
Double Strand Dna Breaks

ABSTRACT Specific regions of genomes (fragile sites) are hot spots for the chromosome rearrangements that are associated with many types of cancer cells. Understanding the molecular mechanisms regulating the stability of chromosome fragile sites, therefore, has important implications in cancer biology. We previously identified two chromosome fragile sites in Saccharomyces cerevisiae that were induced in response to the reduced expression of Pol1p, the catalytic subunit of DNA polymerase α. In the study presented here, we show that reduced levels of Pol3p, the catalytic subunit of DNA polymerase δ, induce instability at these same sites and lead to the generation of a variety of chromosomal aberrations. These findings demonstrate that a change in the stoichiometry of replicative DNA polymerases results in recombinogenic DNA lesions, presumably double-strand DNA breaks.

Sign in / Sign up

Export Citation Format

Share Document