Role of 14-3-3β protein on ovarian folliculogenesis, steroidogenesis and its correlation in the pathogenesis of PCOS in mice

2021 ◽  
pp. 113900
Author(s):  
Shatrudhan Upadhyay ◽  
Amitabh Krishna ◽  
Ajit Singh
Keyword(s):  
Ovarian Folliculogenesis

Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9

2006 ◽  
Vol 74 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Takayo Ota ◽  
Kyung-Bok Choi ◽  
C. Blake Gilks ◽  
Peter C.K. Leung ◽  
Nelly Auersperg
Keyword(s):  
Protein Expression ◽  
Cell Type ◽  
Ovarian Folliculogenesis

Ovarian Folliculogenesis: Emerging Role of In Vitro Maturation of Oocytes and Follicles in Clinical Practice

2003 ◽  
Vol 46 (2) ◽  
pp. 239-253 ◽  
Author(s):  
DOUGLAS T. CARRELL ◽  
SERGEY MOSKOVTSEV ◽  
KAZIM R. CHOHAN ◽  
MATTHEW C. PETERSON
Keyword(s):  
Clinical Practice ◽  
In Vitro Maturation ◽  
Ovarian Folliculogenesis

scholarly journals Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity

2021 ◽  
Vol 11 ◽  
Author(s):  
Anne-Louise Gannon ◽  
Laura O’Hara ◽  
Ian J. Mason ◽  
Anne Jørgensen ◽  
Hanne Frederiksen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Spindle Cell ◽  
Post Partum ◽  
Breast Development ◽  
Sexually Dimorphic ◽  
Adrenal Androgen ◽  
Cell Hyperplasia ◽  
Ovarian Folliculogenesis ◽  
Gland Development

Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in target tissues are well characterized, there is little research covering the role of androgen-signaling within the adrenal itself. Adrenal glands express AR which is essential for the regression of the X-zone in male mice. Female mice also undergo X-zone regression during their first pregnancy, however whether this is also controlled by AR signaling is unknown. To understand the role of the androgen receptor (AR) in the female adrenal, we utilized a Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.

Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency

2020 ◽  
Vol 41 (5) ◽  
pp. 983-997 ◽  
Author(s):  
Raffaella Rossetti ◽  
Ilaria Ferrari ◽  
Ilaria Bestetti ◽  
Silvia Moleri ◽  
Francesco Brancati ◽  
...  
Keyword(s):  
Primary Ovarian Insufficiency ◽  
Missense Mutations ◽  
Ovarian Insufficiency ◽  
Ovarian Folliculogenesis

scholarly journals Microenvironmental changes by placenta-derived mesenchymal stem cells restore the ovarian function in ovariectomized rat via activated PI3K-FOXO3 pathway

2020 ◽  
Author(s):  
Jong Ho Choi ◽  
Jin Seok ◽  
Seung Mook Lim ◽  
Tae Hee Kim ◽  
Gi Jin Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Ovarian Function ◽  
Therapeutic Potential ◽  
Ovariectomized Rat ◽  
Expression Of Genes ◽  
Ovarian Folliculogenesis ◽  
Ovary Function

Abstract Background: Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, the mechanistic studies of the function of these cells have been insufficient. As ovarian failures cause anovulation as well as ovarian steroid hormonal unbalances, the specific aims of this study were to analyze the therapeutic role of placenta derived MSCs (PD-MSCs) in an ovarian-failure ovariectomy (OVX) rat model and evaluate whether PD-MSCs transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. Methods: Blood and ovary tissue were collected and analyzed after various PD-MSCs Tx treatments in the ovariectomized rat model. Changes in the expression of folliculogenesis and ovary regeneration-related genes due to PD-MSCs treatments were analyzed by qRT-PCR, Western blotting, and histological analysis. Results: The levels of hormones related to ovary function were significantly increased in the PD-MSCs Tx groups compared with those of the non-transplantation group (NTx). The follicle numbers in the ovarian tissues were increased along with increased expression of genes related to folliculogenesis for PD-MSCs Tx compared with NTx groups. Furthermore, PD-MSCs Tx induced maturation of follicles by increasing the phosphorylation of GSK3 beta and FOXO3 (p<0.05) and shifting the balance of growth and apoptosis in the oocytes. Conclusions: Taken together, PD-MSCs Tx can restore the ovarian function as well as induce ovarian folliculogenesis via the PI3K/Akt and FOXO signaling pathway.

scholarly journals Expression and Functional Role of Peroxisome Proliferator-Activated Receptor-γ in Ovarian Folliculogenesis in the Sheep1

2003 ◽  
Vol 69 (5) ◽  
pp. 1665-1674 ◽  
Author(s):  
Pascal Froment ◽  
Stéphane Fabre ◽  
Joëlle Dupont ◽  
Claudine Pisselet ◽  
Didier Chesneau ◽  
...  
Keyword(s):  
Functional Role ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ovarian Folliculogenesis

scholarly journals Polycystic Ovary Syndrome: A Brain Disorder Characterized by Eating Problems Originating during Puberty and Adolescence

2020 ◽  
Vol 21 (21) ◽  
pp. 8211
Author(s):  
Régine P. M. Steegers-Theunissen ◽  
Rosalieke E. Wiegel ◽  
Pauline W. Jansen ◽  
Joop S. E. Laven ◽  
Kevin D. Sinclair
Keyword(s):  
Eating Disorders ◽  
Psychological Distress ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Brain Disorder ◽  
Ovary Syndrome ◽  
Hpg Axis ◽  
Psychological Stressors ◽  
Ovarian Folliculogenesis

Polycystic ovary syndrome (PCOS) is an endocrine condition associated with reproductive and psychiatric disorders, and with obesity. Eating disorders, such as bulimia and recurrent dieting, are also linked to PCOS. They can lead to the epigenetic dysregulation of the hypothalamic–pituitary–gonadal (HPG) axis, thereby impacting on ovarian folliculogenesis. We postulate that PCOS is induced by psychological distress and episodes of overeating and/or dieting during puberty and adolescence, when body dissatisfaction and emotional distress are often present. We propose that upregulated activation of the central HPG axis during this period can be epigenetically altered by psychological stressors and by bulimia/recurrent dieting, which are common during adolescence and which can lead to PCOS. This hypothesis is based on events that occur during a largely neglected stage of female reproductive development. To date, most research into the origins of PCOS has focused on the prenatal induction of this disorder, particularly in utero androgenization and the role of anti-Müllerian hormone. Establishing causality in our peripubertal model requires prospective cohort studies from infancy. Mechanistic studies should consider the role of the gut microbiota in addition to the epigenetic regulation of (neuro) hormones. Finally, clinicians should consider the importance of underlying chronic psychological distress and eating disorders in PCOS.

scholarly journals Microenvironmental changes by placenta-derived mesenchymal stem cells restore the ovarian function in ovariectomized rat via activated PI3K-FOXO3 pathway

2020 ◽  
Author(s):  
Jong Ho Choi ◽  
Jin Seok ◽  
Seung Mook Lim ◽  
Tae Hee Kim ◽  
Gi Jin Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Ovarian Function ◽  
Therapeutic Potential ◽  
Ovariectomized Rat ◽  
Expression Of Genes ◽  
Ovarian Folliculogenesis ◽  
Ovary Function

Abstract Background: Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, the mechanistic studies of the function of these cells have been insufficient. As ovarian failures cause anovulation as well as ovarian steroid hormonal unbalances, the specific aims of this study were to analyze the therapeutic role of placenta derived MSCs (PD-MSCs) in an ovarian-failure ovariectomy (OVX) rat model and evaluate whether PD-MSCs transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. Methods: Blood and ovary tissue were collected and analyzed after various PD-MSCs Tx treatments in the ovariectomized rat model. Changes in the expression of folliculogenesis and ovary regeneration-related genes due to PD-MSCs treatments were analyzed by qRT-PCR, Western blotting, and histological analysis. Results: The levels of hormones related to ovary function were significantly increased in the PD-MSCs Tx groups compared with those of the non-transplantation group (NTx). The follicle numbers in the ovarian tissues were increased along with increased expression of genes related to folliculogenesis for PD-MSCs Tx compared with NTx groups. Furthermore, PD-MSCs Tx induced maturation of follicles by increasing the phosphorylation of GSK3 beta and FOXO3 (p<0.05) and shifting the balance of growth and apoptosis in the oocytes. Conclusions: Taken together, PD-MSCs Tx can restore the ovarian function as well as induce ovarian folliculogenesis via the PI3K/Akt and FOXO signaling pathway.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor
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