Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Ai Tsukada; Hiroshi Suemizu; Norie Murayama; Ryohji Takano; Makiko Shimizu; Masato Nakamura; Hiroshi Yamazaki

doi:10.1016/j.yrtph.2013.01.008

Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2013.01.008 ◽

2013 ◽

Vol 65 (3) ◽

pp. 316-324 ◽

Cited By ~ 24

Author(s):

Ai Tsukada ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Ryohji Takano ◽

Makiko Shimizu ◽

...

Keyword(s):

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Melengestrol Acetate ◽

Physiologically Based

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Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2014.06.028 ◽

2014 ◽

Vol 70 (1) ◽

pp. 214-221 ◽

Cited By ~ 17

Author(s):

Masanao Yamashita ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Sayako Nishiyama ◽

Makiko Shimizu ◽

...

Keyword(s):

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human Plasma Concentrations of Tolbutamide and Acetaminophen Extrapolated from in vivo Animal Pharmacokinetics Using in vitro Human Hepatic Clearances and Simple Physiologically Based Pharmacokinetic Modeling for Radio-labeled Microdose Clinical Studies

RADIOISOTOPES ◽

10.3769/radioisotopes.64.509 ◽

2015 ◽

Vol 64 (8) ◽

pp. 509-519 ◽

Cited By ~ 4

Author(s):

Hiroshi YAMAZAKI ◽

Eriko KUNIKANE ◽

Sayako NISHIYAMA ◽

Norie MURAYAMA ◽

Makiko SHIMIZU ◽

...

Keyword(s):

Human Plasma ◽

Clinical Studies ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Animal Pharmacokinetics

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Comment on M.V. Evans and J.C. Caldwell: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280–290, 2010

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2010.07.012 ◽

2010 ◽

Vol 248 (1) ◽

pp. 63-64 ◽

Cited By ~ 2

Author(s):

M.W. Anders ◽

Melvin E. Andersen ◽

Harvey J. Clewell III ◽

Michael L. Gargas ◽

F. Peter Guengerich ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Gas Uptake ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

B6c3f1 Mice ◽

Uptake Data

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Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2015.03.010 ◽

2015 ◽

Vol 72 (1) ◽

pp. 71-76 ◽

Cited By ~ 16

Author(s):

Takamori Miyaguchi ◽

Hiroshi Suemizu ◽

Makiko Shimizu ◽

Satomi Shida ◽

Sayako Nishiyama ◽

...

Keyword(s):

Bisphenol A ◽

Human Urine ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

In Vivo Experiments

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Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo

Drug Metabolism and Disposition ◽

10.1124/dmd.116.069542 ◽

2016 ◽

Vol 44 (7) ◽

pp. 1123-1138 ◽

Cited By ~ 10

Author(s):

Q. J. Yang ◽

J. Fan ◽

S. Chen ◽

L. Liu ◽

H. Sun ◽

...

Keyword(s):

Flow Model ◽

Pharmacokinetic Modeling ◽

Whole Body ◽

Physiologically Based Pharmacokinetic Modeling ◽

Metabolite Kinetics ◽

Physiologically Based Pharmacokinetic ◽

Segregated Flow ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Cited By ~ 18

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Artemisinin Cocrystals for Bioavailability Enhancement. Part 2: In Vivo Bioavailability and Physiologically Based Pharmacokinetic Modeling

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.1c00385 ◽

2021 ◽

Author(s):

Manreet Kaur ◽

Vanessa Yardley ◽

Ke Wang ◽

Jinit Masania ◽

Randolph R. J. Arroo ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Bioavailability Enhancement ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Cited By ~ 7

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Cited By ~ 22

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2016.1147102 ◽

2016 ◽

Vol 46 (12) ◽

pp. 1049-1055 ◽

Cited By ~ 26

Author(s):

Masahiro Utoh ◽

Hiroshi Suemizu ◽

Marina Mitsui ◽

Mirai Kawano ◽

Akiko Toda ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Human Hepatocytes ◽

Physiologically Based Pharmacokinetic Modeling ◽

Common Marmosets ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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