Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass

2000 ◽  
Vol 70 (4) ◽  
pp. 1313-1318 ◽  
Author(s):  
Colleen W Marano ◽  
Leah Ann Garulacan ◽  
Kathleen V Laughlin ◽  
Lisa Igidbashian ◽  
Candace Trace ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Plasma Concentrations ◽  
Tumor Necrosis Factor Receptor ◽  
Necrosis Factor

Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women

2007 ◽  
Vol 97 (01) ◽  
pp. 62-66 ◽  
Author(s):  
Alenka Mavri ◽  
Delphine Bastelica ◽  
Marjorie Poggi ◽  
Pierre Morange ◽  
Franck Peiretti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Plasma Concentrations ◽  
Tumor Necrosis Factor Receptor ◽  
Tnf Receptor ◽  
Obese Women ◽  
The Metabolic Syndrome ◽  
Necrosis Factor ◽  
Pai 1

SummaryThe tumor necrosis factor (TNF) pathway may be implicated in etiopathogenesis of PAI-1 overexpression during obesity. The aim of this study was to investigate the influence of polymorphismA36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, healthy women. Genotypic and allele frequencies did not significantly differ between obese and lean subjects. TNFRSF1A genotypes were significantly associated with sTNFR1 plasma levels in obese women only (p<0.01); TNFRSF1A +36G/G obese carriers exhibited higher sTNFR1 and PAI-1 levels than A carriers (p<0.01 and p<0.05, respectively). In obese women, the presence of the MetS significantly potentiated the elevation of sTNFR1 and PAI-1 levels observed in the TNFRSF1A+36G/G carriers. Our results suggest that association between TNFRSF1A +36G/G genotype and the MetS renders obese women more prone to activation of the TNF pathway reflected by high circulating sTNFR1 and PAI-1 levels.

scholarly journals Maternal plasma concentrations of the soluble tumor necrosis factor receptor 2 are increased prior to the diagnosis of preeclampsia

2009 ◽  
Vol 200 (6) ◽  
pp. 630.e1-630.e8 ◽  
Author(s):  
Baha Sibai ◽  
Roberto Romero ◽  
Mark A. Klebanoff ◽  
Madeline Murguia Rice ◽  
Steve Caritis ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Plasma Concentrations ◽  
Tumor Necrosis Factor Receptor ◽  
Maternal Plasma ◽  
Necrosis Factor
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