Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects

2003 ◽  
Vol 54 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Ronald M Salomon ◽  
Beth Ripley ◽  
John S Kennedy ◽  
Benjamin Johnson ◽  
Dennis Schmidt ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Diurnal Variation ◽  
Orexin A ◽  
Hypocretin 1

Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures

Epilepsia ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1641-1644 ◽  
Author(s):  
Konrad Rejdak ◽  
Ewa Papuć ◽  
Paweł Grieb ◽  
Zbigniew Stelmasiak
Keyword(s):  
Cerebrospinal Fluid ◽  
Orexin A ◽  
Clonic Seizures ◽  
Hypocretin 1

scholarly journals Decreased Cerebrospinal Fluid Orexin-A (Hypocretin-1) Concentrations in Patients after Generalized Convulsive Status Epilepticus

2020 ◽  
Vol 9 (10) ◽  
pp. 3354
Author(s):  
Mojdeh Samzadeh ◽  
Ewa Papuć ◽  
Marzena Furtak-Niczyporuk ◽  
Konrad Rejdak
Keyword(s):  
Cerebrospinal Fluid ◽  
Status Epilepticus ◽  
Neuronal Damage ◽  
Study Groups ◽  
Convulsive Status Epilepticus ◽  
Orexin A ◽  
Diagnostic Lumbar Puncture ◽  
Turn Over ◽  
Hypocretin 1

The effects of status epilepticus on the orexin/hypocretin system have yet to be investigated. The present study aimed to assay orexin-A/hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized convulsive status epilepticus (GCSE). The study groups included 20 GCSE patients, 24 patients diagnosed with epilepsy but remaining in remission (ER), and 25 normal controls (CTR). Diagnostic lumbar puncture was performed in GCSE patients within 3–10 days of seizure cessation, as well as in the ER and to CTR subjects. Among all GCSE patients, the outcome was graded according to the modified Rankin Scale (mRS) at 1-month follow-up. Orexin-A levels were measured in unextracted CSF samples, using a commercial radioimmunoassay. There was a significant overall difference in median CSF orexin-A concentrations between GCSE, RE, and CTR patients (p < 0.001). The lowest concentrations were noted in the GCSE group compared to ER (p < 0.001) or CTR (p < 0.001). CSF orexin-A levels in GCSE patients inversely correlated with clinical outcome as assessed on the mRS at 1-month follow-up (r = −0.55; p = 0.1). In conclusion, CSF orexin-A levels may serve as a biomarker of increased turn-over of the peptide or post-SE neuronal damage, and implicates the orexin system in the pathogenesis of SE.

scholarly journals Cerebrospinal Fluid Melanin-Concentrating Hormone (MCH) and Hypocretin-1 (HCRT-1, Orexin-A) in Alzheimer’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63136 ◽  
Author(s):  
Frank M. Schmidt ◽  
Juergen Kratzsch ◽  
Hermann-Josef Gertz ◽  
Mandy Tittmann ◽  
Ina Jahn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Orexin A ◽  
Melanin Concentrating Hormone ◽  
Hypocretin 1

scholarly journals Relationship between cerebrospinal fluid concentrations of orexin A/hypocretin-1 and body composition in humans

Peptides ◽  
2018 ◽  
Vol 102 ◽  
pp. 26-30 ◽  
Author(s):  
João C.P. Santiago ◽  
Markus Otto ◽  
Werner Kern ◽  
Paul Christian Baier ◽  
Manfred Hallschmid
Keyword(s):  
Cerebrospinal Fluid ◽  
Body Composition ◽  
Orexin A ◽  
Hypocretin 1

scholarly journals Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151288 ◽  
Author(s):  
Kim Boddum ◽  
Mathias Hvidtfelt Hansen ◽  
Poul Jørgen Jennum ◽  
Birgitte Rahbek Kornum
Keyword(s):  
Cerebrospinal Fluid ◽  
Day Length ◽  
Orexin A ◽  
Hypocretin 1

Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity

2004 ◽  
Vol 117 (3) ◽  
pp. 155-158 ◽  
Author(s):  
Paulo J.F. Martins ◽  
Vânia D'Almeida ◽  
Mário Pedrazzoli ◽  
Ling Lin ◽  
Emmanuel Mignot ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Short Term ◽  
Orexin A ◽  
Hypocretin 1
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