Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord

2000 ◽  
Vol 865 (2) ◽  
pp. 283-285 ◽  
Author(s):  
David J McAdoo ◽  
Guo-Ying Xu ◽  
Gregory Robak ◽  
Michael G Hughes ◽  
Edna M Price
Keyword(s):  
Spinal Cord ◽  
Glutamate Uptake ◽  
Glutamate Release ◽  
Rat Spinal Cord ◽  
Experimental Injury

Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

2000 ◽  
Vol 871 (2) ◽  
pp. 175-180 ◽  
Author(s):  
R.D Azbill ◽  
X Mu ◽  
J.E Springer
Keyword(s):  
Spinal Cord ◽  
Glutamate Uptake ◽  
Rat Spinal Cord ◽  
High Affinity

Presynaptic TRPA1 activation enhances glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord

2007 ◽  
Vol 58 ◽  
pp. S180
Author(s):  
Masafumi Kosugi ◽  
Terumasa Nakatsuka ◽  
Tsugumi Fujita ◽  
Takahiro Aoyama ◽  
Eiichi Kumamoto
Keyword(s):  
Spinal Cord ◽  
Glutamate Release ◽  
Substantia Gelatinosa ◽  
Rat Spinal Cord ◽  
Adult Rat ◽  
Adult Rat Spinal Cord

Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake

2012 ◽  
Vol 63 (3) ◽  
pp. 415-426 ◽  
Author(s):  
Sara Ebrahimi Nasrabady ◽  
Anujaianthi Kuzhandaivel ◽  
Athena Akrami ◽  
Elena Bianchetti ◽  
Marco Milanese ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glutamate Uptake ◽  
Rat Spinal Cord ◽  
Parp 1 ◽  
Unusual Increase

The Effect of Spider Toxin PhTx3-4, ω-Conotoxins MVIIA and MVIIC on Glutamate Uptake and on Capsaicin-Induced Glutamate Release and [Ca2+]i in Spinal cord Synaptosomes

2010 ◽  
Vol 31 (2) ◽  
pp. 277-283 ◽  
Author(s):  
Jomara M. Gonçaves ◽  
Juliano Ferreira ◽  
Marco Antonio M. Prado ◽  
Marta N. Cordeiro ◽  
Michael Richardson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glutamate Uptake ◽  
Glutamate Release ◽  
Spider Toxin

Neuroprotection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro

Neuroscience ◽  
2010 ◽  
Vol 165 (3) ◽  
pp. 996-1010 ◽  
Author(s):  
G. Margaryan ◽  
C. Mattioli ◽  
M. Mladinic ◽  
A. Nistri
Keyword(s):  
Spinal Cord ◽  
Neonatal Rat ◽  
Rat Spinal Cord ◽  
Experimental Injury

Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord

Pain ◽  
2005 ◽  
Vol 115 (1) ◽  
pp. 60-70 ◽  
Author(s):  
Wen-Jinn Liaw ◽  
Robert L. Stephens ◽  
Brian C. Binns ◽  
Yachun Chu ◽  
Jehuda P. Sepkuty ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glutamate Uptake ◽  
Rat Spinal Cord ◽  
Sensory Transmission

Cannabinoid-Induced Presynaptic Inhibition of Glutamatergic EPSCs in Substantia Gelatinosa Neurons of the Rat Spinal Cord

2001 ◽  
Vol 86 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Valerie Morisset ◽  
Laszlo Urban
Keyword(s):  
Spinal Cord ◽  
Cannabinoid Receptor ◽  
Glutamate Release ◽  
Receptor Activation ◽  
Substantia Gelatinosa ◽  
Strong Increase ◽  
High Threshold ◽  
Rat Spinal Cord ◽  
Excitatory Transmission ◽  
C Fibers

The effect of cannabinoids on excitatory transmission in the substantia gelatinosa was investigated using intracellular recording from visually identified neurons in a transverse slice preparation of the juvenile rat spinal cord. In the presence of strychnine and bicuculline, perfusion of the cannabinoid receptor agonist WIN55,212-2 reduced the frequency and the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Furthermore, the frequency of miniature EPSCs (mEPSCs) was also decreased by WIN55,212-2, whereas their amplitude was not affected. Similar effects were reproduced using the endogenous cannabinoid ligand anandamide. The effects of both agonists were blocked by the selective CB1 receptor antagonist SR141716A. Electrical stimulation of high-threshold fibers in the dorsal root evoked a monosynaptic EPSC in lamina II neurons. In the presence of WIN55,212-2, the amplitude of the evoked EPSC (eEPSCs) was reduced, and the paired-pulse ratio was increased. The reduction of the eEPSC following CB1 receptor activation was unlikely to have a postsynaptic origin because the response to AMPA, in the presence of 1 μM TTX, was unchanged. To investigate the specificity of this synaptic inhibition, we selectively activated the nociceptive C fibers with capsaicin, which induced a strong increase in the frequency of EPSCs. In the presence of WIN55,212-2, the response to capsaicin was diminished. In conclusion, these results strongly suggest a presynaptic location for CB1 receptors whose activation results in inhibition of glutamate release in the spinal dorsal horn. The strong inhibitory effect of cannabinoids on C fibers may thereby contribute to the modulation of the spinal excitatory transmission, thus producing analgesia at the spinal level.

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