Simultaneous activation and opioid modulation of long-term potentiation in the dentate gyrus and the hippocampal CA3 region after stimulation of the perforant pathway in freely moving rats

2001 ◽  
Vol 913 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Manfred Krug ◽  
Rudolf Brödemann ◽  
Maria Wagner
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Freely Moving Rats ◽  
Perforant Pathway ◽  
Term Potentiation ◽  
Hippocampal Ca3 ◽  
Simultaneous Activation ◽  
Freely Moving ◽  
Stimulation Of

scholarly journals Intracerebroventricular injection of oxidant and antioxidant molecules affects long-term potentiation in urethane anaesthetized rats

2008 ◽  
pp. 269-273
Author(s):  
A Viggiano ◽  
E Viggiano ◽  
M Monda ◽  
A Viggiano ◽  
S Ascione ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Control Group ◽  
High Frequency Stimulation ◽  
Perforant Pathway ◽  
Term Potentiation ◽  
Stimulation Of

Production of superoxide anions in the incubation medium of hippocampal slices can induce long-term potentiation (LTP). Other reactive oxygen species (ROS) such as hydrogen peroxide are able to modulate LTP and are likely to be involved in aging mechanisms. The present study explored whether intracerebroventricular (ICV) injection of oxidant or antioxidant molecules could affect LTP in vivo. With this aim in mind, field excitatory post-synaptic potentials (fEPSPs) elicited by stimulation of the perforant pathway were recorded in the dentate gyrus of the hippocampal formation in urethane-anesthetized rats. N-acetyl-Lcysteine, hydrogen peroxide (H2O2) or hypoxanthine/xanthineoxidase solution (a superoxide producing system) were administrated by ICV injection. The control was represented by a group injected with saline ICV. Ten minutes after the injection, LTP was induced in the granule cells of the dentate gyrus by high frequency stimulation of the perforant pathway. Neither the H2O2 injection or the N-acetyl-L-cysteine injection caused any variation in the fEPSP at the 10-min post-injection time point, whereas the superoxide generating system caused a significant increase in the fEPSP. Moreover, at 60 min after tetanic stimulation, all treatments attenuated LTP compared with the control group. These results show that ICV administration of oxidant or antioxidant molecules can modulate LTP in vivo in the dentate gyrus. Particularly, a superoxide producing system can induce potentiation of the synaptic response. Interestingly, ICV injection of oxidants or antioxidants prevented a full expression of LTP compared to the saline injection.

Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine

2005 ◽  
Vol 83 (1) ◽  
pp. 72-78 ◽  
Author(s):  
William Almaguer-Melian ◽  
Yeneissy Rojas-Reyes ◽  
Armando Alvare ◽  
Juan C. Rosillo ◽  
Julietta U. Frey ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Freely Moving Rats ◽  
Term Potentiation ◽  
Freely Moving

Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats

2011 ◽  
Vol 216 (1) ◽  
pp. 375-380 ◽  
Author(s):  
Esmaeil Akbari ◽  
Fereshteh Motamedi ◽  
Farzaneh Ghiafeh Davoodi ◽  
Maryam Noorbakhshnia ◽  
Elham Ghanbarian
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Freely Moving Rats ◽  
Term Potentiation ◽  
Freely Moving
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