Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test

1997 ◽  
Vol 323 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Moacir S Faria ◽  
Marcelo N Muscará ◽  
Heitor Moreno ◽  
Simone A Teixeira ◽  
Heidi B Dias ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Maze Test ◽  
Plus Maze

scholarly journals The Study of the Effect of Sodium Nitroprusside in Anxiety-Like Behavior in Mice in Comparison With Diazepam

2020 ◽  
pp. 485-490
Author(s):  
Abeer Mudhafar Al-Humaidhi ◽  
Afrah Thiab Hlail ◽  
Semaa H. Shalal
Keyword(s):  
Nitric Oxide ◽  
Sodium Nitroprusside ◽  
Elevated Plus Maze ◽  
Research Attention ◽  
Anxiolytic Drug ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Nitric Oxide Pathway ◽  
Light Dark Box

Anxiety has become a highly paramount field of research attention in psychopharmacology today. Sundry studies have shown a nitric oxide role in the regulation of anxiety. The goal of the study was to investigate sodium nitroprusside ability to affect anxiety-like behavior in mice and to compare this effect with the standard anxiolytic drug, diazepam, using both plus maze test and light/dark box test. The results revealed that sodium nitroprusside at a dose of 1 mg/kg had a significant effect on the behavior in both of the elevated plus maze test and light/dark test. However, at higher dose (3 mg/kg), it has significantly increased the anxiogenic-like effect in the light/dark box test. Diazepam at a dose of 2 mg/kg increased the time spent in open arms in elevated plus maze test and that in light chambers of light/dark test. These outcomes suggest that a nitric oxide pathway seems to play an important role in anxiety. Furthermore, sodium nitroprusside at a dose of 1 mg/kg showed a nearly anxiolytic ability, when compared with diazepam.

Nitric oxide involvement in estrous cycle-dependent changes of the behavioral responses of female rats in the elevated plus-maze test

2007 ◽  
Vol 178 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Hamid Reza Sadeghipour ◽  
Mehdi Ghasemi ◽  
Hamed Sadeghipour ◽  
Kiarash Riazi ◽  
Mohammad Soufiabadi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Estrous Cycle ◽  
Elevated Plus Maze ◽  
Behavioral Responses ◽  
Female Rats ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Cycle Dependent

Age-Dependence in Alterations in Nitric Oxide Synthesis in Cardiovascular System during Adaptation to Physical Training

2010 ◽  
Vol 1 (4) ◽  
pp. 345-356 ◽  
Author(s):  
O. V. Bazilyuk ◽  
Anatolii V. Kotsuruba ◽  
Lyubov. G. Stepanenko ◽  
Sergey A. Talanov ◽  
Yu. P. Korchak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular System ◽  
Physical Training ◽  
Nitric Oxide Synthesis ◽  
Age Dependence
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