Redox potential of the small intestine lumer in a model of experimental hemorrhage in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A195-A195
Author(s):  
J PAULA ◽  
E SPINEDI ◽  
A DUBIN ◽  
D BUSTOS ◽  
J DAVOLOS
Keyword(s):  
Small Intestine ◽  
Redox Potential

scholarly journals HOMEOSTASIS CHANGE IN THE SMALL INTESTINE WITH DISTURBED REGIONAL BLOOD FLOW IN EARLY POSTNATAL ONTOGENESIS

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Sergey Anatol`evich Markos`yan
Keyword(s):  
Lipid Peroxidation ◽  
Blood Flow ◽  
Small Intestine ◽  
Redox Potential ◽  
Blood Supply ◽  
Regional Blood Flow ◽  
Intestinal Wall ◽  
Early Age ◽  
Ischemic Region ◽  
Oxygen Coefficient

Objective: A study of the ischemic damage course and regeneration in the small intestine with disturbed regional blood flow in early postnatal ontogenesis.Materials and Methods: The experiments were carried out on 30 puppies at the age from 1 to 4 weeks. The state of regional blood flow in the ischemic area of the small intestine was investigated by blood filling of tissues, metabolism - by redox potential, oxygen pressure and diffusion oxygen coefficient, lipid peroxidation activity and catalase activity. Database formation and statistical calculations were performed using the applied programmes "Microsoft Excel", "ANOVA" for "Windows".Results: The performed research showed that in animals of early age pronounced microcirculatory disorders were observed. About this evidenced significant tissue bloodfilling in the ischemic region of the small intestine. Essential disorder of the blood supply in the organ naturally led to a pronounced fall in the redox potential, the oxygen pressure, and the diffusion oxygen coefficient in the tissues.On a level with the disturbances in the electrogenesis and tissue oxygenation, we found a significant diminution in their antioxidant capacity, as evidenced by a pronounced increase in lipid peroxidation and a decrease in catalytic activity. Insufficient oxygen supply of tissues caused the development of irreversible changes in the intestinal wall, the disorder of the organ motility with frequent appearance of small intestinal intussusception.Conclusions: A significant disturbance of the small intestine blood supply at the early age, caused by an operating trauma, leads to a pronounced decrease in electrical activity and oxygenation of the organ tissues, accompanied by marked metabolic disorders.Oxygen starvation of tissues in the ischemic region of the small intestine at the early age contributes to the development of irreversible changes in the intestinal wall, and frequent disruption of the regeneration process in this area. Keywords: small intestine; local ischemia; early age

Redox potential of the small intestine lumer in a model of experimental hemorrhage in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A195
Author(s):  
Juan A. De Paula ◽  
Emma Spinedi ◽  
Amaldo Dubin ◽  
Daniel Bustos ◽  
Jorge Davolos
Keyword(s):  
Small Intestine ◽  
Redox Potential

Electron probe x-ray microanalysis and electron microscopy of amino acid absorption and transport by the small intestine: inhibition by chemical poisons and correlation to the elemental composition of the epithelial cells

1986 ◽  
Vol 44 ◽  
pp. 134-135
Author(s):  
A. J. Tousimis
Keyword(s):  
Small Intestine ◽  
Amino Acid ◽  
Epithelial Cells ◽  
Elemental Composition ◽  
Isotope Labeling ◽  
Structural Components ◽  
X Ray ◽  
Human Small Intestine ◽  
Transport Studies

The elemental composition of amino acids is similar to that of the major structural components of the epithelial cells of the small intestine and other tissues. Therefore, their subcellular localization and concentration measurements are not possible by x-ray microanalysis. Radioactive isotope labeling: I131-tyrosine, Se75-methionine and S35-methionine have been successfully employed in numerous absorption and transport studies. The latter two have been utilized both in vitro and vivo, with similar results in the hamster and human small intestine. Non-radioactive Selenomethionine, since its absorption/transport behavior is assumed to be the same as that of Se75- methionine and S75-methionine could serve as a compound tracer for this amino acid.

The protease phenotype and crystalline nature of the granules of intraepithelial mast cells in Trichinella spiralis-infected mice

1995 ◽  
Vol 53 ◽  
pp. 818-819
Author(s):  
D.S. Friend ◽  
N. Ghildyal ◽  
M.F. Gurish ◽  
K.F. Austen ◽  
R.L. Stevens
Keyword(s):  
Small Intestine ◽  
Mast Cells ◽  
Epithelial Cells ◽  
Lamina Propria ◽  
Trichinella Spiralis ◽  
Intestinal Epithelial ◽  
Carboxypeptidase A ◽  
C3h Mice ◽  
Granule Morphology ◽  
Crystalline Nature

Trichinella spiralis induces a profound mastocytosis and eosinophilia in the small intestine of the infected mouse. Mouse mast cells (MC) store in their granules various combinations of at least five chymotryptic chymases [designated mouse MC protease (mMCP) 1 to 5], two tryptic proteases designated mMCP-6 and mMCP-7 and an exopeptidase, carboxypeptidase A (mMC-CPA). Using antipeptide, protease -specific antibodies to these MC granule proteases, immunohistochemistry was done to determine the distribution, number and protease phenotype of the MCs in the small intestine and spleen 10 to >60 days after Trichinella infection of BALB/c and C3H mice. TEM was performed to evaluate the granule morphology of the MCs between intestinal epithelial cells and in the lamina propria (mucosal MCs) and in the submucosa, muscle and serosa of the intestine (submucosal MCs).As noted in the table below, the number of submucosal MCs remained constant throughout the study. In contrast, on day 14, the number of MCs in the mucosa increased ~25 fold. Increased numbers of MCs were observed between epithelial cells in the mucosal crypts, in the lamina propria and to a lesser extent, between epithelial cells of the intestinal villi.

Immunochemical visualization of cyclic AMP in myenteric neurons of guinea-pig small intestine+

2001 ◽  
Vol 120 (5) ◽  
pp. A683-A683
Author(s):  
J GUZMAN ◽  
S SHARP ◽  
J YU ◽  
F MCMORRIS ◽  
A WIEMELT ◽  
...  
Keyword(s):  
Small Intestine ◽  
Cyclic Amp ◽  
Guinea Pig ◽  
Myenteric Neurons

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

Effects of stimulating protease-activated receptors on myenteric newrons in guinea-pig small intestine

2001 ◽  
Vol 120 (5) ◽  
pp. A114-A114
Author(s):  
C GAO ◽  
H HU ◽  
S LIU ◽  
N GAO ◽  
Y XIA ◽  
...  
Keyword(s):  
Small Intestine ◽  
Guinea Pig ◽  
Protease Activated Receptors

Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine

2001 ◽  
Vol 120 (5) ◽  
pp. A660-A660
Author(s):  
D MCMICHAEL ◽  
A DAVIES ◽  
E MARSHMAN ◽  
P OTTEWELL ◽  
J JENKINS ◽  
...  
Keyword(s):  
Small Intestine ◽  
Knockout Mouse ◽  
Gene Array ◽  
Murine Small Intestine ◽  
Induced Apoptosis
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