The Narrow Spectrum Kinase Inhibitor (NSKI) TOP1288 Demonstrates Potent Anti-Inflammatory Effects in a T Cell Adoptive Transfer Colitis Model Through a Topical Mode of Action

2017 ◽  
Vol 152 (5) ◽  
pp. S31
Author(s):  
Yemisi Solanke ◽  
Martyn Foster ◽  
Matthew C. Fyfe ◽  
Adele Rowley ◽  
Sameer Sirohi ◽  
...  
2020 ◽  
Vol 70 (1) ◽  
pp. 16-24
Author(s):  
Charlie C Hsu ◽  
Karuna Patil ◽  
Audrey Seamons ◽  
Thea L Brabb ◽  
Piper M Treuting ◽  
...  

Murine norovirus (MNV) infection is highly prevalent in laboratory mice. Although MNV infection does not typically induce clinical disease in most laboratory mice, infection may nonetheless affect mouse models of disease by altering immune responses. We previously reported that MNV altered the bacterial-induced mouse model of inflammatory bowel disease (IBD) using Helicobacter-infected Mdr1a–/– mice. Therefore, we hypothesized that MNV infection would exacerbate another mouse model of IBD, the T-cell adoptive transfer (AT) model. In this model, Helicobacter infection is used to accelerate the progression of IBD induced by AT of naïve CD4+CD45RBhigh T cells into B6.129S7- Rag1tm1Mom/J (Rag1–/–) mice. We evaluated the effects of MNV infection in both Helicobacter-accelerated as well as Helicobacter-free AT models. In our studies, Helicobacter-infected Rag1–/– mice that received CD4+CD45RBhigh T cells through AT rapidly developed weight loss and typhlocolitis; MNV infection had no effect on disease severity or rate of progression. In the absence of Helicobacter infection, progression of IBD caused by AT of CD4+CD45RBhigh T cells was slower and typhlocolitis was less severe; this inflammation likewise was unaltered by MNV infection. These results indicate that MNV infection does not alter IBD progression and severity in the CD4+CD45RBhigh T-cell AT model in Rag1–/– mice.


2017 ◽  
Vol 152 (5) ◽  
pp. S766
Author(s):  
Martyn Foster ◽  
Paolo Biancheri ◽  
Matthew C. Fyfe ◽  
Thomas T. MacDonald ◽  
Adele Rowley ◽  
...  

2011 ◽  
Vol 186 (6) ◽  
pp. 3327-3335 ◽  
Author(s):  
Maria Salagianni ◽  
Eftychia Lekka ◽  
Ardiana Moustaki ◽  
Eleni G. Iliopoulou ◽  
Constantin N. Baxevanis ◽  
...  

2015 ◽  
Vol 172 (15) ◽  
pp. 3805-3816 ◽  
Author(s):  
Wing S To ◽  
Susan R Aungier ◽  
Alison J Cartwright ◽  
Kazuhiro Ito ◽  
Kim S Midwood

2013 ◽  
Vol 4 ◽  
Author(s):  
Gozlan Yosi ◽  
Alteber Zoya ◽  
Azulay Meir ◽  
Sharbi Yunger Adi ◽  
Tzehoval Esther ◽  
...  

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 3047-3047 ◽  
Author(s):  
Arnav Mehta ◽  
Yeon Joo Kim ◽  
Lidia Robert ◽  
Begonya Comin-Anduix ◽  
Beata Berent-Maoz ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document