The Narrow Spectrum Kinase Inhibitor (NSKI) TOP1288 Demonstrates Potent Anti-Inflammatory Effects in a T Cell Adoptive Transfer Colitis Model Through a Topical Mode of Action

2017 ◽  
Vol 152 (5) ◽  
pp. S31
Author(s):  
Yemisi Solanke ◽  
Martyn Foster ◽  
Matthew C. Fyfe ◽  
Adele Rowley ◽  
Sameer Sirohi ◽  
...  
Keyword(s):  
T Cell ◽  
Adoptive Transfer ◽  
Mode Of Action ◽  
Kinase Inhibitor ◽  
Narrow Spectrum ◽  
Anti Inflammatory ◽  
Cell Adoptive Transfer ◽  
Colitis Model

scholarly journals Lack of Effect of Murine Norovirus Infection on the CD4+ CD45RBhigh T-cell Adoptive Transfer Mouse Model of Inflammatory Bowel Disease

2020 ◽  
Vol 70 (1) ◽  
pp. 16-24
Author(s):  
Charlie C Hsu ◽  
Karuna Patil ◽  
Audrey Seamons ◽  
Thea L Brabb ◽  
Piper M Treuting ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
T Cell ◽  
Mouse Model ◽  
Adoptive Transfer ◽  
Bowel Disease ◽  
Murine Norovirus ◽  
Laboratory Mice ◽  
Inflammatory Bowel ◽  
Cell Adoptive Transfer

Murine norovirus (MNV) infection is highly prevalent in laboratory mice. Although MNV infection does not typically induce clinical disease in most laboratory mice, infection may nonetheless affect mouse models of disease by altering immune responses. We previously reported that MNV altered the bacterial-induced mouse model of inflammatory bowel disease (IBD) using Helicobacter-infected Mdr1a–/– mice. Therefore, we hypothesized that MNV infection would exacerbate another mouse model of IBD, the T-cell adoptive transfer (AT) model. In this model, Helicobacter infection is used to accelerate the progression of IBD induced by AT of naïve CD4+CD45RBhigh T cells into B6.129S7- Rag1tm1Mom/J (Rag1–/–) mice. We evaluated the effects of MNV infection in both Helicobacter-accelerated as well as Helicobacter-free AT models. In our studies, Helicobacter-infected Rag1–/– mice that received CD4+CD45RBhigh T cells through AT rapidly developed weight loss and typhlocolitis; MNV infection had no effect on disease severity or rate of progression. In the absence of Helicobacter infection, progression of IBD caused by AT of CD4+CD45RBhigh T cells was slower and typhlocolitis was less severe; this inflammation likewise was unaltered by MNV infection. These results indicate that MNV infection does not alter IBD progression and severity in the CD4+CD45RBhigh T-cell AT model in Rag1–/– mice.

The Pharmacological Profile of TOP1288, a Narrow Spectrum Kinase Inhibitor (NSKI) in Clinical Development as an Anti-Inflammatory Treatment for Ulcerative Colitis

2017 ◽  
Vol 152 (5) ◽  
pp. S766
Author(s):  
Martyn Foster ◽  
Paolo Biancheri ◽  
Matthew C. Fyfe ◽  
Thomas T. MacDonald ◽  
Adele Rowley ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Kinase Inhibitor ◽  
Clinical Development ◽  
Pharmacological Profile ◽  
Narrow Spectrum ◽  
Anti Inflammatory

scholarly journals NK Cell Adoptive Transfer Combined with Ontak-Mediated Regulatory T Cell Elimination Induces Effective Adaptive Antitumor Immune Responses

2011 ◽  
Vol 186 (6) ◽  
pp. 3327-3335 ◽  
Author(s):  
Maria Salagianni ◽  
Eftychia Lekka ◽  
Ardiana Moustaki ◽  
Eleni G. Iliopoulou ◽  
Constantin N. Baxevanis ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Adoptive Transfer ◽  
Regulatory T Cell ◽  
Nk Cell ◽  
Cell Adoptive Transfer

scholarly journals Potent anti‐inflammatory effects of the narrow spectrum kinase inhibitor RV 1088 on rheumatoid arthritis synovial membrane cells

2015 ◽  
Vol 172 (15) ◽  
pp. 3805-3816 ◽  
Author(s):  
Wing S To ◽  
Susan R Aungier ◽  
Alison J Cartwright ◽  
Kazuhiro Ito ◽  
Kim S Midwood
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Membrane ◽  
Kinase Inhibitor ◽  
Rheumatoid Arthritis Synovial Membrane ◽  
Narrow Spectrum ◽  
Anti Inflammatory

scholarly journals "First AID" for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation.

2013 ◽  
Vol 4 ◽  
Author(s):  
Gozlan Yosi ◽  
Alteber Zoya ◽  
Azulay Meir ◽  
Sharbi Yunger Adi ◽  
Tzehoval Esther ◽  
...  
Keyword(s):  
T Cell ◽  
Adoptive Transfer ◽  
Somatic Hypermutation ◽  
First Aid ◽  
Affinity Maturation ◽  
Tcr Affinity ◽  
Cell Adoptive Transfer

Acquired resistance to T cell adoptive transfer by inflammation-induced melanoma dedifferentiation.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 3047-3047 ◽  
Author(s):  
Arnav Mehta ◽  
Yeon Joo Kim ◽  
Lidia Robert ◽  
Begonya Comin-Anduix ◽  
Beata Berent-Maoz ◽  
...  
Keyword(s):  
T Cell ◽  
Adoptive Transfer ◽  
Acquired Resistance ◽  
Cell Adoptive Transfer
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