Mo1836 IMPACT OF THERAPEUTIC STRATEGIES ON INTESTINAL RESECTION RATE IN PAEDIATRIC INFLAMMATORY BOWEL DISEASES: A POPULATION-BASED COHORT STUDY OVER A 24-YEAR PERIOD (1988-2011)

2020 ◽  
Vol 158 (6) ◽  
pp. S-942-S-943
Author(s):  
Delphine Ley ◽  
Ariane Leroyer ◽  
Claire Dupont ◽  
Helene Sarter ◽  
Valérie Bertrand ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Resection ◽  
Population Based ◽  
Therapeutic Strategies ◽  
Resection Rate ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals OP02 Impact of therapeutic strategies on intestinal resection rate in paediatric inflammatory bowel diseases: A population-based cohort study over a 24-year period (1988–2011)

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S001-S003
Author(s):  
D Ley ◽  
A Leroyer ◽  
C Dupont ◽  
H Sarter ◽  
V Bertrand ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Intestinal Resection ◽  
Population Based ◽  
Therapeutic Strategies ◽  
Resection Rate ◽  
Related Hospitalisation ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
The Impact ◽  
Over Time

Abstract Background Few data are available at the population level on the impact of the changes in therapeutic strategies over the last decades on inflammatory bowel diseases (IBD) long-term outcomes. We have evaluated the impact of immunosuppressants (IS) and anti-TNF introduction on intestinal resection rate, hospitalisation, and Crohn’s disease (CD) behaviour progression in a large population-based paediatric-onset IBD cohort. Methods Paediatric-onset IBD (<17 years) were issued from a prospective population-based study in France between 1988 and 2011 and were retrospectively followed until 2013. Risks for intestinal resection, hospitalisation and complicated CD behaviour (stricturing or penetrating) were compared between three diagnostic periods: 1988–1993 (P1), 1994–2000 (P2) and 2001–2011 (P3) using Kaplan–Meier survival analyses. Results One thousand and sixty-one patients diagnosed with CD (n = 800) or ulcerative colitis (UC, n = 261) were followed up during a median of 8.9 years (IQR: 5.0–14.7). Median age at diagnosis was 14.3 years (IQR: 11.8–16.0) and half of patients were female (n = 530, 50%). Over time, in CD, the IS and anti-TNF exposure rate increased from, respectively, 32% (P1) to 75% (P3) and from 0% (P1) to 51% (P3) at 5 years. In UC, IS and anti-TNF exposure increased from, respectively, 9% (P1) to 65% (P3) and from 0% (P1) to 40% (P3) at 5 years. In parallel, risk for intestinal resection at 5 years significantly declined in CD (P1: 35%, P2: 30%, P3: 20%, p < 0.05). No significant change in 5-year colectomy risk in UC was observed (P1: 14%, P2: 19%, P3: 9%, p = 0.08). Exposure to corticosteroid at 5 years of diagnosis did not change over time (P1: 10%, P2: 10%, P3: 8%, p = 0.54). Risk for IBD-flare-related hospitalisation at 5 years was similar over time in CD (P1: 43%, P2: 45%, P3: 43%, p = 0.60) and UC (P1: 31%, P2: 46%, P3: 52%, p = 0.10). Progression to a complicated behaviour in CD at 5 years did not change over time (P1: 31%, P2: 33%, P3: 25%, p = 0.20). Conclusion In parallel with the increased use of IS and anti-TNF agents, risk for intestinal resection within 5 years after diagnosis decreased in paediatric CD, whereas risks for flare-related hospitalisation and behaviour progression remained unchanged over a 24-year period.

scholarly journals Risk of intestinal and extra-intestinal cancers in patients with inflammatory bowel diseases: A population-based cohort study in northeastern Italy

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0235142
Author(s):  
Martina Taborelli ◽  
Michele Sozzi ◽  
Stefania Del Zotto ◽  
Federica Toffolutti ◽  
Marcella Montico ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Bowel Diseases ◽  
Northeastern Italy ◽  
Inflammatory Bowel

Mo1828 THE EPIDEMIOLOGY OF INFLAMMATORY BOWEL DISEASES AMONG IMMIGRANTS TO DENMARK: A POPULATION-BASED COHORT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-939-S-940
Author(s):  
Manasi Agrawal ◽  
Santa Shrestha ◽  
Giulia Corn ◽  
Nete Munk Nielsen ◽  
Morten Frisch ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Place of upbringing in early childhood as related to inflammatory bowel diseases in adulthood: a population-based cohort study in Northern Europe

2014 ◽  
Vol 29 (6) ◽  
pp. 429-437 ◽  
Author(s):  
Signe Timm ◽  
Cecilie Svanes ◽  
Christer Janson ◽  
Torben Sigsgaard ◽  
Ane Johannessen ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Northern Europe ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Risk of Cancer in Patients With Inflammatory Bowel Diseases: A Nationwide Population-based Cohort Study With 30 Years of Follow-up Evaluation

2014 ◽  
Vol 12 (2) ◽  
pp. 265-273.e1 ◽  
Author(s):  
Michael D. Kappelman ◽  
Dora K. Farkas ◽  
Millie D. Long ◽  
Rune Erichsen ◽  
Robert S. Sandler ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Risk Of Cancer

scholarly journals P788 Risks and predictors of osteoporosis in inflammatory bowel diseases: a nationwide Korean population-based cohort study

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S515-S516
Author(s):  
T J Kim ◽  
S M Kong ◽  
J B Shin ◽  
E R Kim ◽  
S N Hong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Korean Population ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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