Fr164 COEXISTING INFLAMMATORY BOWEL DISEASE AND BARRETT'S ESOPHAGUS IS ASSOCIATED WITH INCREASED ESOPHAGEAL DYSPLASIA: A PROPENSITY MATCHED COHORT STUDY

2021 ◽  
Vol 160 (6) ◽  
pp. S-244-S-245
Author(s):  
Matthew Fasullo ◽  
Aditya Sreenivasen ◽  
Erik A. Holzwanger ◽  
Charles A. Lavender ◽  
Milan Patel ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Barrett’S Esophagus ◽  
Bowel Disease ◽  
Barrett's Esophagus ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Esophageal Dysplasia ◽  
Inflammatory Bowel

Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register-based matched cohort study

2020 ◽  
Vol 51 (11) ◽  
pp. 1022-1030 ◽  
Author(s):  
Bojing Liu ◽  
Alkwin Wanders ◽  
Karin Wirdefeldt ◽  
Arvid Sjölander ◽  
Michael C. Sachs ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Bowel Disease ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Inflammatory Bowel ◽  
Subsequent Risk

scholarly journals 207 – Increased Incidence of Malignancy in Patients with Elderly-Onset Inflammatory Bowel Disease: A Population-Based Matched Cohort Study

2019 ◽  
Vol 156 (6) ◽  
pp. S-43
Author(s):  
Ellen Kuenzig ◽  
Sanjay K. Murthy ◽  
Therese A. Stukel ◽  
Geoffrey C. Nguyen ◽  
Gilaad Kaplan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Bowel Disease ◽  
Population Based ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Elderly Onset ◽  
Inflammatory Bowel

scholarly journals Inflammatory bowel disease- and Barrett’s esophagus-associated neoplasia: the old, the new, and the persistent struggles

2019 ◽  
Vol 7 (6) ◽  
pp. 379-395
Author(s):  
Dipti M Karamchandani ◽  
Qin Zhang ◽  
Xiao-Yan Liao ◽  
Jing-Hong Xu ◽  
Xiu-Li Liu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Barrett’S Esophagus ◽  
Bowel Disease ◽  
Barrett's Esophagus ◽  
Endoscopic Examination ◽  
Premalignant Lesions ◽  
Adequate Treatment ◽  
Histologic Evaluation ◽  
Disease Entities ◽  
Inflammatory Bowel

Abstract Early diagnosis of and adequate therapy for premalignant lesions in patients with inflammatory bowel disease (IBD) and Barrett's esophagus (BE) has been shown to decrease mortality. Endoscopic examination with histologic evaluation of random and targeted biopsies remains the gold standard for early detection and adequate treatment of neoplasia in both these diseases. Although eventual patient management (including surveillance and treatment) depends upon a precise histologic assessment of the initial biopsy, accurately diagnosing and grading IBD- and BE-associated dysplasia is still considered challenging by many general as well as subspecialized pathologists. Additionally, there are continuing updates in the literature regarding the diagnosis, surveillance, and treatment of these disease entities. This comprehensive review discusses the cancer risk, detailed histopathological features, diagnostic challenges, and updates as well as the latest surveillance and treatment recommendations in IBD- and BE-associated dysplasia.

scholarly journals Co-existing inflammatory bowel disease and Barrett’s esophagus is associated with esophageal dysplasia: a propensity score-matched cohort

2021 ◽  
Vol 09 (10) ◽  
pp. E1524-E1529
Author(s):  
Matthew Fasullo ◽  
Aditya Sreenivasen ◽  
Erik Holzwanger ◽  
Charles Lavender ◽  
Milan Patel ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Propensity Score ◽  
Bowel Disease ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Segment Length ◽  
Matched Cohort ◽  
Inflammatory Cascade ◽  
Esophageal Dysplasia ◽  
Inflammatory Bowel

Abstract Background and study aims Barrettʼs esophagus (BE) and inflammatory bowel disease (IBD) predispose to the development of dysplasia and cancer. It is unclear if the inflammatory cascade seen in IBD affects disease progression in BE. We aimed to determine if patients with BE who have co-existing IBD had a higher risk of dysplasia, nodular disease, or longer segments than BE patients without IBD. Patients and methods This was a multicenter, retrospective propensity score-matched cohort study. We compared rates of dysplasia, nodular disease, and segment length in patients with BE and IBD (cases) to patients with BE who did not have IBD (controls). Controls were 1:1 propensity score matched with controls for age, sex, body mass index (BMI), smoking, and hiatal hernia. Results A total of 132 patients were included in the IBD + BE group and 132 patients in the BE group. Patients with IBD + BE had higher rates of esophageal dysplasia compared to controls (15.9 % vs. 6.1 % [adjusted odds ratio [OR]: 2.9, 95 % CI: 1.2–6.9]) and more nodules (9.8 % vs. 3.0 % [adjusted OR: 3.5, 95 % CI: 1.1–11.0]). IBD + BE group was also associated with longer BE segments (43.9 % vs. 12.1 % [OR: 5.7, 95 % CI: 3.0–10.6]). Conclusions Co-existing IBD may increase the risk of dysplasia and esophageal nodules in patients with BE. Our findings may have implications for BE surveillance intervals in IBD patients. Prospective studies are needed to confirm our findings.

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