Dose, Efficacy and Acceptability of Oral Sodium Phosphate Solution for Bowel Preparation in Children and Adolescents: A Randomized Single Blinded Study

2005 ◽  
Vol 61 (5) ◽  
pp. AB93
Author(s):  
Mahmoud Sabri ◽  
William Thompson ◽  
Wendy Henderson ◽  
Edward Barksdale ◽  
Carlo Di Lorenzo ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Bowel Preparation ◽  
Sodium Phosphate ◽  
Phosphate Solution ◽  
Blinded Study ◽  
Sodium Phosphate Solution ◽  
Oral Sodium Phosphate ◽  
Oral Sodium ◽  
Oral Sodium Phosphate Solution

Oral Sodium Phosphate Solution

Drugs ◽  
2004 ◽  
Vol 64 (15) ◽  
pp. 1697-1714 ◽  
Author(s):  
Monique P Curran ◽  
Greg L Plosker
Keyword(s):  
Sodium Phosphate ◽  
Phosphate Solution ◽  
Sodium Phosphate Solution ◽  
Oral Sodium Phosphate ◽  
Oral Sodium ◽  
Oral Sodium Phosphate Solution

scholarly journals Colon Cleansing before Colonoscopy: Does Oral Sodium Phosphate Solution Still Make Sense?

2009 ◽  
Vol 23 (3) ◽  
pp. 210-214 ◽  
Author(s):  
Douglas K Rex ◽  
Stephen J Vanner
Keyword(s):  
Sodium Phosphate ◽  
The United States ◽  
Phosphate Solution ◽  
Over The Counter ◽  
Colon Cleansing ◽  
Sodium Phosphate Solution ◽  
Oral Sodium Phosphate ◽  
Colonoscopy Preparation ◽  
Oral Sodium ◽  
Oral Sodium Phosphate Solution

Oral sodium phosphate (NaP) solution has been withdrawn from the market in the United States but remains available for over-the-counter purchase for bowel preparation for colonoscopy in Canada. The present review summarizes recent data regarding the renal toxicity of oral NaP as well as its efficacy and tolerability relative to other preparations. Given the availability of effective alternatives to NaP solution, its use for colonoscopy preparation in Canada should be limited. Candidate patients for oral NaP solution should be assessed for eligibility and preparation instructions should adhere to the current recommendations for maximizing the safety of oral NaP.

scholarly journals Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
S. Schanz ◽  
W. Kruis ◽  
O. Mickisch ◽  
B. Küppers ◽  
P. Berg ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Adverse Events ◽  
Bowel Preparation ◽  
Sodium Phosphate ◽  
Vital Signs ◽  
Multicenter Trial ◽  
Phosphate Solution ◽  
Blinded Study ◽  
Sodium Phosphate Solution ◽  
Oral Sodium Phosphate

Background: Adequate bowel preparation is essential for accurate colonoscopy. Both oral sodium phosphate (NaP) and polyethylene glycol-based lavage (PEG-ELS) are used predominantly as bowel cleansing modalities. NaP has gained popularity due to low drinking volume and lower costs. The purpose of this randomized multicenter observer blinded study was to compare three groups of cleansing (NaP, NaP + sennosides, PEG-ELS + sennosides) in reference to tolerability, acceptance, and cleanliness. Patient and Methods: 355 outpatients between 18 and 75 years were randomized into three groups (A, B, C) receiving NaP = A, NaP, and sennosides = B or PEG-ELS and sennosides = C. Gastroenterologists performing colonoscopies were blinded to the type of preparation. All patients documented tolerance and adverse events. Vital signs, premedication, completeness, discomfort, and complications were recorded. A quality score (0–4) of cleanliness was generated. Results: The three groups were similar with regard to age, sex, BMI, indication for colonoscopy, and comorbidity. Drinking volumes (L) (A = 4.33 + 1.2, B = 4.56 + 1.18, C = 4.93 + 1.71) were in favor of NaP (P = .005). Discomfort from ingested fluid was recorded in A = 39.8% (versus C: P = .015), B = 46.6% (versus C: P = .147), and C = 54.6%. Differences in tolerability and acceptance between the three groups were statistically not significant. No differences in adverse events and the cleanliness effects occurred in the three groups (P = .113). The cleanliness quality scores 0–2 were calculated in A: 77.7%, B: 86.7%, and C: 85.2%. Conclusions: These data fail to demonstrate significant differences in tolerability, acceptance, and preparation quality between the three types of bowel preparation for colonoscopy. Cleansing with NaP was not superior to PEG-ELS.

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