Photodynamic therapy for treatment of early adenocarcinoma in Barrett's esophagus

1993 ◽  
Vol 39 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Bergein Overholt ◽  
Masoud Panjehpour ◽  
Elmeria Tefftellar ◽  
Mark Rose
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Early Adenocarcinoma

scholarly journals Photodynamic Therapy in Barrett’s Esophagus: Results of Treatment of 17 Patients

2006 ◽  
Vol 20 (4) ◽  
pp. 261-264 ◽  
Author(s):  
Alan A Weiss ◽  
Holly AR Wiesinger ◽  
David Owen
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Early Adenocarcinoma

BACKGROUND: Barrett’s esophagus (BE) with dysplasia may progress to esophageal adenocarcinoma. Photodynamic therapy is a promising treatment for BE.OBJECTIVE: To determine if photodynamic therapy is an acceptable alternative to esophagectomy in BE patients with high-grade dysplasia or early adenocarcinoma.METHODS: Seventeen patients were treated with photodynamic therapy for BE and high-grade dysplasia or early esophageal adenocarcinoma. Patients with residual Barrett’s epithelium were treated with supplemental argon plasma coagulation or potassium titanyl phosphate laser. Patients underwent follow-up endoscopy three, six, nine and 12 months post-treatment, then every six to 12 months. Mean follow-up was 21 months.RESULTS: High-grade dysplasia or early adenocarcinoma was completely eliminated in nine of 15 (60%) patients. High-grade dysplasia was downgraded in one patient, persisted in one patient and progressed in four patients. Two patients with early esophageal adenocarcinoma were nonresponders. Complications included stricture, sunburn, urticaria, small pleural effusions, esophageal spasm and transient atrial fibrillation.CONCLUSIONS: Photodynamic therapy with supplemental ablation is a good, noninvasive therapy for elimination of high-grade dysplasia and early adenocarcinoma in BE. Failure to eliminate dysplastic epithelium occurred in 40% of the patients, thereby necessitating careful follow-up.

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix

Histopathologic characteristics of early adenocarcinoma in Barrett's esophagus

Cancer ◽  
1991 ◽  
Vol 68 (8) ◽  
pp. 1731-1736 ◽  
Author(s):  
Tadashi Nishimaki ◽  
Arnulf H. Hölscher ◽  
Michael Schüler ◽  
Elfriede Bollschweiler ◽  
Karen Becker ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Early Adenocarcinoma

Effects of telomerase expression on photodynamic therapy of Barrett's esophagus

2003 ◽  
Author(s):  
Kenneth K. Wang ◽  
Marlys Anderson ◽  
Navtej Buttar ◽  
Louis-Michel WongKeeSong ◽  
Lynn Borkenhagen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus
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