scholarly journals Association of coagulation factor V with the platelet cytoskeleton.

1982 ◽  
Vol 257 (8) ◽  
pp. 4557-4563
Author(s):  
G P Tuszynski ◽  
P N Walsh ◽  
J R Piperno ◽  
A Koshy
Keyword(s):  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V

Coagulation Factor V Leiden Mutation Was Detected in the Patients with Activated Protein C Resistance in Thailand

1998 ◽  
Vol 80 (08) ◽  
pp. 344-345 ◽  
Author(s):  
Pasra Arnutti ◽  
Motofumi Hiyoshi ◽  
Wichai Prayoonwiwat ◽  
Oytip Nathalang ◽  
Chamaiporn Suwanasophon ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Coagulation Factor V

Phenotyping and Genotyping of Coagulation Factor V Leiden

1996 ◽  
Vol 75 (02) ◽  
pp. 267-269 ◽  
Author(s):  
H Engel ◽  
L Zwang ◽  
H H D M van Vliet ◽  
J J Michiles ◽  
J Stibbe ◽  
...  
Keyword(s):  
Factor V Leiden ◽  
Coagulation Factor ◽  
Diagnostic Value ◽  
Resistance Test ◽  
Amplification Refractory Mutation System ◽  
Factor V ◽  
Chain Reactions ◽  
Apc Resistance ◽  
Specificity And Sensitivity ◽  
Coagulation Factor V

SummaryThe currently used activated Protein C resistance test demonstrated to be of limited diagnostic value for the detection of the mutant Factor V Leiden. Moreover, this assay is not useful for patients under anticoagulant therapy. A modification of the APC resistance test, applying Factor V deficient plasma is described which demonstrates a specificity and sensitivity of 1.0. The superiority of the modified APC resistance test over the existing APC resistance test was verified by genotyping.For that purpose, the Amplification Refractory Mutation System (ARMS) was applied to the detection of the G to A mutation at position 1691 in the gene encoding coagulation Factor V. The mutation at that position could be easily detected by using each of two allele-specific oligonucleotide primers concomitantly with one common primer in two separate polymerase chain reactions, thereby amplifying a fragment of 186 base-pairs of the Factor V gene.

Coagulation Factor V: An Old Star Shines Again

1997 ◽  
Vol 78 (01) ◽  
pp. 427-433 ◽  
Author(s):  
Jan Rosing ◽  
Guido Tans
Keyword(s):  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V

scholarly journals Thrombin-catalyzed activation of human coagulation factor V.

1982 ◽  
Vol 257 (11) ◽  
pp. 6556-6564 ◽  
Author(s):  
K Suzuki ◽  
B Dahlbäck ◽  
J Stenflo
Keyword(s):  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V

scholarly journals Factor V Kuwait: A Novel Mutation in the Coagulation Factor V Gene Discovered in Kuwait

2006 ◽  
Vol 15 (2) ◽  
pp. 102-105
Author(s):  
Mehrez M. Jadaon ◽  
Ali A. Dashti ◽  
Hend L. Lewis
Keyword(s):  
Novel Mutation ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Factor V Gene ◽  
V Gene

Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men

1995 ◽  
Vol 332 (14) ◽  
pp. 912-917 ◽  
Author(s):  
Paul M. Ridker ◽  
Charles H. Hennekens ◽  
Klaus Lindpaintner ◽  
Meir J. Stampfer ◽  
Paul R. Eisenberg ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Venous Thrombosis ◽  
Coagulation Factor ◽  
Factor V ◽  
Healthy Men ◽  
Gene Coding ◽  
Coagulation Factor V ◽  
Apparently Healthy

The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis

Blood ◽  
2003 ◽  
Vol 102 (8) ◽  
pp. 2856-2861 ◽  
Author(s):  
Hongmin Sun ◽  
Tony L. Yang ◽  
Angela Yang ◽  
Xixi Wang ◽  
David Ginsburg
Keyword(s):  
Gene Expression ◽  
Bacterial Artificial Chromosome ◽  
Transgenic Mice ◽  
Coagulation Factor ◽  
Artificial Chromosome ◽  
Coagulation Cascade ◽  
Factor V ◽  
Wild Type ◽  
Plasma Factor ◽  
Coagulation Factor V

Abstract Coagulation factor V (FV) is a central regulator of the coagulation cascade. Circulating FV is found in plasma and within platelet α granules. The specific functions of these distinct FV pools are uncertain. We now report the generation of transgenic mice with FV gene expression restricted to either the liver or megakaryocyte/platelet lineage using bacterial artificial chromosome (BAC) constructs. Six of 6 independent albumin BAC transgenes rescue the neonatal lethal hemorrhage of FV deficiency. Rescued mice all exhibit liver-specific Fv expression at levels ranging from 6% to 46% of the endogenous Fv gene, with no detectable FV activity within the platelet pool. One of the 3 Pf4 BAC transgenes available for analysis also rescues the lethal FV null phenotype, with FV activity restricted to only the platelet pool (approximately 3% of the wild-type FV level). FV-null mice rescued by either the albumin or Pf4 BAC exhibit nearly normal tail bleeding times. These results demonstrate that Fv expression in either the platelet or plasma FV pool is sufficient for basal hemostasis. In addition, these findings indicate that the murine platelet and plasma FV pools are biosynthetically distinct, in contrast to a previous report demonstrating a plasma origin for platelet FV in humans.

scholarly journals Novel Role for Galectin-8 Protein as Mediator of Coagulation Factor V Endocytosis by Megakaryocytes

2012 ◽  
Vol 287 (11) ◽  
pp. 8327-8335 ◽  
Author(s):  
Claudia Zappelli ◽  
Carmen van der Zwaan ◽  
Daphne C. Thijssen-Timmer ◽  
Koen Mertens ◽  
Alexander B. Meijer
Keyword(s):  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V
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