scholarly journals Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids

1989 ◽  
Vol 264 (8) ◽  
pp. 4349-4355 ◽  
Author(s):  
U Saxena ◽  
L D Witte ◽  
I J Goldberg
Keyword(s):  
Fatty Acids ◽  
Endothelial Cell ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase ◽  
Plasma Lipoproteins

scholarly journals Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

2013 ◽  
Vol 33 (7) ◽  
pp. 1706-1713 ◽  
Author(s):  
Marius R. Robciuc ◽  
Marianna Maranghi ◽  
Anna Lahikainen ◽  
Daniel Rader ◽  
Andre Bensadoun ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Serum Free Fatty Acids ◽  
Serum Free

Adipose tissue in experimental nephrotic syndrome

1963 ◽  
Vol 205 (4) ◽  
pp. 702-706 ◽  
Author(s):  
Alisa Gutman ◽  
Eleazar Shafrir
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Nephrotic Syndrome ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase ◽  
Epididymal Adipose Tissue ◽  
Adequate Nutrition ◽  
Defective Metabolism ◽  
Inadequate Food Intake

Epididymal adipose tissue of aminonucleoside-treated rats, investigated 3 to 6 days after induction of the nephrotic syndrome, had low glycogen levels and showed impaired esterification of free fatty acids and assimilation of lipoprotein triglyceride and markedly reduced liberation of lipoprotein lipase. These results were found to be influenced by the inadequate food intake of the acutely nephrotic animals and comparable to the values of control rats fasted for 2 days. On return to adequate nutrition, which occurred 12–20 days after aminonucleoside treatment, adipose tissue glycogen and free fatty acid assimilation returned toward normal levels but lipoprotein-lipase liberation remained below normal. In rats rendered nephrotic by antikidney serum, the assimilation of free fatty acids and lipoprotein-triglyceride by adipose tissue was impaired in spite of only minor reduction in food consumption. The results indicate that the defective metabolism of adipose tissue in nephrotic animals may be contributory to the nephrotic hypertriglyceridemia.

Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase

1999 ◽  
Vol 77 (10) ◽  
pp. 813-818 ◽  
Author(s):  
Ryna Levy ◽  
Gene R Herzberg
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Stearic Acid ◽  
Eicosapentaenoic Acid ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase ◽  
Alpha Linolenic Acid ◽  
Hydrolysis Of ◽  
Long Chain

The hydrolysis of chylomicrons enriched in long-chain n-3 fatty acids by cardiac lipoprotein lipase was studied. In 60 min, 24.8% of the triacylglycerol fatty acids were released as free fatty acids. The fatty acids were hydrolyzed at different rates. DHA (docosahexaenoic acid, 22:6n-3) and EPA (eicosapentaenoic acid, 20:5n-3) were released at rates significantly less than average. Stearic acid (18:0), 20:1n-9, and alpha-linolenic acid (18:3n-3) were released significantly faster than average. There was no relationship between the rate of release of a fatty acid and the number of carbons or the number of double bonds. Lipoprotein lipase selectively hydrolyzes the fatty acids of chylomicron triacylglycerols. This selectively will result in remnants that are relatively depleted in 18:0, 20:1, and 18:3 and relatively enriched in 20:5 and 22:6.Key words: lipoprotein lipase, chylomicrons, fish oil, eicosapentaenoic acid, docosahexaenoic acid.

Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation

2016 ◽  
Vol 19 (4) ◽  
pp. e12673 ◽  
Author(s):  
Hung-Yu Sun ◽  
Chun-Chieh Lin ◽  
Pei-Ju Tsai ◽  
Wei-Jen Tsai ◽  
Jin-Ching Lee ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase ◽  
Lipid Accumulation ◽  
Hcv Infection ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

Fat-cell heat production, adipose tissue fatty acids, lipoprotein lipase activity and plasma lipoproteins in adiposis dolorosa

1991 ◽  
Vol 81 (6) ◽  
pp. 793-798 ◽  
Author(s):  
Birger Fagher ◽  
Mario Monti ◽  
Peter Nilsson-Ehle ◽  
Björn Åukesson
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Metabolic Activity ◽  
Heat Production ◽  
Plasma Lipoproteins ◽  
Additional Patient ◽  
Fat Cells ◽  
Bicarbonate Buffer ◽  
Adiposis Dolorosa

1. Gluteal adipose tissue was examined in 13 patients with generalized adiposis dolorosa, a clinical condition characterized by painful adiposity with a chronic intractable course. The total metabolic activity of fat cells, isolated by collagenase and suspended in Krebs-Ringer bicarbonate buffer with glucose and insulin, was assessed by the measurement of heat production at 37°C using microcalorimetry. 2. Fat cells were markedly enlarged; their metabolic activity expressed in terms of μW/g, but not in pW/cell, was significantly decreased when compared with both lean and weight-matched non-painful subjects. Both mean values were, however, significantly higher than in grossly obese subjects with similar mean cell size. Heat production as expressed per g of tissue, but not per cell, was inversely correlated with body mass index. One additional patient had unilateral disease, and fat cells from the painful side had a lower heat production than cells from the unaffected side. 3. The fatty acid composition of adipose tissue, as determined by g.c., revealed a significantly increased proportion of monounsaturated (18:1 and 16:1) at the expense of saturated (14:0 and 18:0) fatty acids compared with healthy control subjects. The activity of adipose tissue lipoprotein lipase was slightly, but not significantly, decreased. 4. It is concluded that a metabolic pathogenetic factor cannot be ruled out in adiposis dolorosa. As the results do not explain the nature of the diffuse pain, further studies need to be performed.

Free fatty acids: the possible regulators of muscle lipoprotein lipase

1985 ◽  
Vol 13 (1) ◽  
pp. 129-130 ◽  
Author(s):  
L. BUDOHOSKI ◽  
S. KOZLOWSKI ◽  
H. KACIUBA-USCILKO ◽  
K. NAZAR
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipoprotein Lipase
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