scholarly journals Proteolytic degradation of calf thymus terminal deoxynucleotidyl transferase.

1982 ◽  
Vol 257 (10) ◽  
pp. 5700-5706 ◽  
Author(s):  
L M Chang ◽  
P Plevani ◽  
F J Bollum
Keyword(s):  
Terminal Deoxynucleotidyl Transferase ◽  
Proteolytic Degradation ◽  
Calf Thymus

Nucleoside 5′-triphosphates modified at sugar residues as substrates for calf thymus terminal deoxynucleotidyl transferase and for AMV reverse transcriptase

1986 ◽  
Vol 868 (2-3) ◽  
pp. 136-144 ◽  
Author(s):  
Robert S. Beabealashvilli ◽  
Andrei V. Scamrov ◽  
Tamara V. Kutateladze ◽  
Alexander M. Mazo ◽  
Alexander A. Krayevsky ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Calf Thymus

4′-Thio-5-Ethyl-2′-Deoxyuridine5′-Triphosphate (TEDUTP): Synthesis and Substrate Properties in DNA-Synthesizing Systems

1996 ◽  
Vol 7 (5) ◽  
pp. 237-242 ◽  
Author(s):  
L.A. Alexandrova ◽  
D.G. Semizarov ◽  
A.A. Krayevsky ◽  
R.T. Walker
Keyword(s):  
Terminal Deoxynucleotidyl Transferase ◽  
Selective Toxicity ◽  
Avian Myeloblastosis Virus ◽  
Reverse Transcriptases ◽  
Calf Thymus ◽  
Immunodeficiency Virus ◽  
Substrate Properties ◽  
Infected Cells ◽  
First Time

An efficient synthesis of the 5′-phosphate and 5′-triphosphate of a 4′-thio-2′-deoxynucleoside is described for the first time. The 5′-triphosphate of the antiherpesvirus agent 4′-thio-5-ethyl-2′-deoxyuridine (TEDU) has been shown to be a good substrate for human placental DNA polymerase α, calf thymus terminal deoxynucleotidyl transferase, and the reverse transcriptases of human immunodeficiency virus and avian myeloblastosis virus. As it is known that TEDU is a substrate only for herpesvirus-encoded thymidine kinases and not the cellular kinases, it is likely that the utilization of TEDUTP by DNA-synthesizing enzymes results in the selective toxicity seen in vitro in herpesvirus-infected cells.

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