scholarly journals Dopamine D1 receptors characterized with [3H]SCH 23390. Solubilization of a guanine nucleotide-sensitive form of the receptor.

1986 ◽  
Vol 261 (18) ◽  
pp. 8397-8406
Author(s):  
H B Niznik ◽  
N Y Otsuka ◽  
A Dumbrille-Ross ◽  
D Grigoriadis ◽  
A Tirpak ◽  
...  
Keyword(s):  
Sch 23390 ◽  
D1 Receptors ◽  
Guanine Nucleotide ◽  
Dopamine D1 Receptors

Dopamine D1-Receptors Modulate Lateral Inhibition Between Principal Cells of the Nucleus Accumbens

2005 ◽  
Vol 93 (3) ◽  
pp. 1816-1819 ◽  
Author(s):  
Stefano Taverna ◽  
Barbara Canciani ◽  
Cyriel M. A. Pennartz
Keyword(s):  
Nucleus Accumbens ◽  
Sch 23390 ◽  
Brain Slices ◽  
D1 Receptor ◽  
D1 Receptors ◽  
Projection Neurons ◽  
Dopamine D1 Receptors ◽  
Principal Cells ◽  
Rat Nucleus Accumbens ◽  
Selection Of

One of the current hypotheses on dopamine in the physiology of motivation posits that this neurotransmitter regulates filtering and selection of inputs to the nucleus accumbens. The effects of dopamine (100 μM) and the D1-receptor agonist SKF 38393 (20–50 μM) on GABAergic synaptic transmission between pairs of principal cells of rat nucleus accumbens were studied by using simultaneous dual patch-clamp recordings in acutely prepared brain slices. Both compounds attenuated postsynaptic responses induced by presynaptic firing and this effect was reversed by the D1-receptor antagonist SCH 23390 (25 μM). This attenuating effect of dopamine D1-receptors may act to diminish competitive interactions between single projection neurons or ensembles in the nucleus accumbens.

Specific binding of 3H-SCH 23390 to dopamine D1 receptors

Life Sciences ◽  
1986 ◽  
Vol 38 (16) ◽  
pp. 1507-1514 ◽  
Author(s):  
Peter H. Andersen ◽  
Frederik C. Grønvald
Keyword(s):  
Specific Binding ◽  
Sch 23390 ◽  
D1 Receptors ◽  
Dopamine D1 Receptors

scholarly journals ROLE OF DOPAMINE D1- AND D2-RECEPTORS IN THE DELTA1-OPIOIDERGIC IMMUNOSTIMULATION

2012 ◽  
Vol 67 (5) ◽  
pp. 55-57
Author(s):  
M. A. Cheido ◽  
M. M. Gevorkyan
Keyword(s):  
Immune Response ◽  
Opioid Receptors ◽  
Sch 23390 ◽  
D2 Receptors ◽  
D1 Receptors ◽  
Dopamine D1 Receptors ◽  
Selective Antagonist ◽  
D1 And D2 Receptors ◽  
Peptide Agonist

The study has shown that activation of delta1-opioid receptors by a highly selective peptide agonist DPDPE (100 µg/kg) results in a significant increase of the immune response to antigen (SRBC, 5×108) in CBA mice. SCH-23390 (1 mg/kg), a selective antagonist of the postsynaptic dopamine D1-receptors, and selective D2-blocker haloperidol (1 mg/kg) prevented immunostimulating effect of DPDPE. Comparison of effects of the antagonists suggests that delta1-opioidergic immunostimulation has more significant impact due to involvement of dopamine D1-receptors. 

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