scholarly journals Inhibition of post-translational modification and surface expression of a melanoma-associated chondroitin sulfate proteoglycan by diethylcarbamazine or ammonium chloride.

1986 ◽  
Vol 261 (11) ◽  
pp. 5121-5129
Author(s):  
R C Spiro ◽  
W G Parsons ◽  
S K Perry ◽  
J P Caulfield ◽  
A Hein ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Ammonium Chloride ◽  
Surface Expression ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Post Translational Modification

scholarly journals Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements

Blood ◽  
1996 ◽  
Vol 87 (3) ◽  
pp. 1134-1139 ◽  
Author(s):  
FG Behm ◽  
FO Smith ◽  
SC Raimondi ◽  
CH Pui ◽  
ID Bernstein
Keyword(s):  
Monoclonal Antibody ◽  
Chondroitin Sulfate ◽  
Lymphoblastic Leukemia ◽  
Central Nervous System Involvement ◽  
Surface Expression ◽  
Chondroitin Sulfate Proteoglycan ◽  
Cell Surface Expression ◽  
Gene Rearrangements ◽  
Sulfate Proteoglycan ◽  
Mll Gene

Monoclonal antibody 7.1, which recognizes the chondroitin sulfate proteoglycan molecule NG2, was used to screen prospectively blast cells from 104 consecutive children at initial presentation with acute lymphoblastic leukemia (ALL). Reactivity with this antibody was found in 9 cases (8.6%), of whom 5 had a t(4;11)(q21;q23) and 4 had a t(11;19)(p13;q23). None of the NG2- cases had either translocation. Southern blot analysis disclosed MLL gene rearrangement in only the 9 cases with 7.1 reactivity plus the t(4;11)(q21;q23) or t(11;19)(q23;p13) translocation. MLL gene rearrangements were not detected in 89 patient leukemic samples that did not express NG2, including 7 patients with del(11)(q23) or inv(11)(p13q23). As expected from the association with t(4;11) and t(11;19), NG2+ cases were significantly more likely to be infants, to have hyperleukocytosis and central nervous system involvement, to be CD10-, and to express myeloid- associated antigens CD15 and CD65. Despite short follow-up duration, 3 of the NG2+ cases have relapsed while the other 101 patients remain in remission. Thus, blast cell surface expression of NG2 is useful for identifying patients with ALL having t(4;11) or t(11;19) translocations that are associated with poor prognosis, especially in the infant age group.

scholarly journals Biosynthesis of Chondroitin Sulfate Proteoglycan

1972 ◽  
Vol 247 (12) ◽  
pp. 3838-3847
Author(s):  
John R. Baker ◽  
Lennart Rodén ◽  
Allen C. Stoolmiller
Keyword(s):  
Chondroitin Sulfate ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

scholarly journals Brevican, a Chondroitin Sulfate Proteoglycan of Rat Brain, Occurs as Secreted and Cell Surface Glycosylphosphatidylinositol-anchored Isoforms

1995 ◽  
Vol 270 (45) ◽  
pp. 27206-27212 ◽  
Author(s):  
Constanze I. Seidenbecher ◽  
Karin Richter ◽  
Uwe Rauch ◽  
Reinhard Fässler ◽  
Craig C. Garner ◽  
...  
Keyword(s):  
Cell Surface ◽  
Chondroitin Sulfate ◽  
Rat Brain ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

Detection of chondroitin sulfates and decorin in developing fetal and neonatal rat lung

2002 ◽  
Vol 282 (3) ◽  
pp. L484-L490 ◽  
Author(s):  
Yiqiong Wang ◽  
Kaori Sakamoto ◽  
Jody Khosla ◽  
Philip L. Sannes
Keyword(s):  
Extracellular Matrix ◽  
Chondroitin Sulfate ◽  
Wide Distribution ◽  
Neonatal Rat ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Rat Lung ◽  
Adult Rats ◽  
Chondroitin Sulfates ◽  
Monospecific Antibodies

Chondroitin sulfates and their related proteoglycans are components of extracellular matrix that act as key determinants of growth and differentiation characteristics of developing lungs. Changes in their immunohistochemical distribution during progressive organ maturation were examined with monospecific antibodies to chondroitin sulfate, a nonbasement membrane chondroitin sulfate proteoglycan, and the specific chondroitin sulfate-containing proteoglycan decorin in whole fetuses and lungs from newborn and adult rats. Alveolar and airway extracellular matrix immunostained heavily in the prenatal rat for both chondroitin sulfate and chondroitin sulfate proteoglycan, whereas decorin was confined to developing airways and vessels. These sites retained their respective levels of reactivity with all antibodies through 1–10 days postnatal but thereafter became progressively more diminished and focal in alveolar regions. The heavy staining seen early in development was interpreted to reflect a significant and wide distribution of chondroitin sulfates, chondroitin sulfate proteoglycans, and decorin in rapidly growing tissues, whereas the reduced and more focal reactivity observed at later time points coincided with known focal patterns of localization of fibrillar elements of the extracellular matrix and a more differentiated state.

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