Role of genomic mechanisms on cAMP-dependent positive inotropism in isolated left atrium of rat

Life Sciences ◽  
1999 ◽  
Vol 65 (5) ◽  
pp. 565-572 ◽  
Author(s):  
JoséManuel Rubín ◽  
Agustín Hidalgo ◽  
MaJoséGarcía De Boto ◽  
Manuel Sánchez
2008 ◽  
Vol 52 (2) ◽  
pp. 161-166 ◽  
Author(s):  
Lucía Velasco ◽  
Lorena Secades ◽  
Carmen Bordallo ◽  
Javier Bordallo ◽  
María José García de Boto ◽  
...  

2020 ◽  
Author(s):  
Reza Mohseni‐badalabadi ◽  
Mohammad Sahebjam ◽  
Mehdi Mohseni‐badalabadi ◽  
Kaveh Hosseini

2001 ◽  
Vol 422 (1-3) ◽  
pp. 101-107 ◽  
Author(s):  
Carmen Bordallo ◽  
José Manuel Rubı́n ◽  
Ana Belén Varona ◽  
Begoña Cantabrana ◽  
Agustı́n Hidalgo ◽  
...  

1985 ◽  
Vol 248 (6) ◽  
pp. H812-H817
Author(s):  
D. Saito ◽  
T. Hyodo ◽  
K. Takeda ◽  
Y. Abe ◽  
H. Tani ◽  
...  

Adenosine is a prime candidate for the role of mediator between myocardial metabolic state and coronary blood flow. However, there are few reports concerning the direct effects of exogenously added adenosine on coronary autoregulation. The present investigation in the open-chest dog studied the effects of a threshold dose of intracoronary adenosine infusion on reactive hyperemia following brief coronary occlusions. The infused dose did not increase nonocclusive flow by greater than 10%. Adenosine enhanced total hyperemic flow at all occlusions tested (5, 10, 15, 20, and 30 s). Aminophylline pretreatment reduced reactive hyperemia below the control level even in the presence of an intracoronary infusion of adenosine. Adenosine injected into the left atrium and intracoronarily infused papaverine did not affect hyperemic response to 5- and 15-s coronary occlusions. The results suggest that a minimum dose of exogenously added adenosine enhances myocardial reactive hyperemia, possibly by potentiating the effects of endogenous adenosine released during ischemia.


2009 ◽  
Vol 136 (3) ◽  
pp. 258-262 ◽  
Author(s):  
Dimitris Tousoulis ◽  
Kostas Zisimos ◽  
Charalambos Antoniades ◽  
Elli Stefanadi ◽  
Gerasimos Siasos ◽  
...  

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