Germline mutation induction at mouse repeat DNA loci by chemical mutagens

2003 ◽  
Vol 526 (1-2) ◽  
pp. 63-73 ◽  
Author(s):  
Carles Vilariño-Güell ◽  
Andrew G Smith ◽  
Yuri E Dubrova
Keyword(s):  
Germline Mutation ◽  
Mutation Induction ◽  
Chemical Mutagens ◽  
Repeat Dna

scholarly journals Mutation Induction in Melilotus Alba Annua by Chemical Mutagens 1

Crop Science ◽  
1968 ◽  
Vol 8 (5) ◽  
pp. 631-632 ◽  
Author(s):  
A. Kleinhofs ◽  
H. J. Gorz ◽  
F. A. Haskins
Keyword(s):  
Mutation Induction ◽  
Chemical Mutagens ◽  
Melilotus Alba

No correlation between germline mutation at repeat DNA and meiotic crossover in male mice exposed to X-rays or cisplatin

2000 ◽  
Vol 457 (1-2) ◽  
pp. 79-91 ◽  
Author(s):  
Ruth Barber ◽  
Mark Plumb ◽  
Andrew G. Smith ◽  
Carolina E. Cesar ◽  
Emma Boulton ◽  
...  
Keyword(s):  
Germline Mutation ◽  
X Rays ◽  
Male Mice ◽  
Meiotic Crossover ◽  
Repeat Dna

Spontaneous and Induced Minisatellite Instability in the Human Genome

1997 ◽  
Vol 93 (5) ◽  
pp. 383-390 ◽  
Author(s):  
Alec J. Jeffreys
Keyword(s):  
Human Genome ◽  
Tandem Repeat ◽  
High Frequency ◽  
Spontaneous Mutation ◽  
Intrinsic Property ◽  
Mutation Induction ◽  
Human Populations ◽  
Forensic Dna ◽  
Dna Turnover ◽  
Repeat Dna

1. Minisatellites, originally developed for forensic DNA fingerprinting and profiling, have also provided extremely informative systems for analysing processes of tandem repeat DNA turnover in the human genome. 2. Minisatellite instability involves distinct mutation processes in somatic and germline cells. In sperm, tandem repeat instability most likely arises at meiosis as a by-product of high-frequency meiotic recombination events occurring in and near minisatellites. Instability is not an intrinsic property of minisatellite repeat DNA, but instead appears to be controlled by flanking recombination initiation elements. 3. Minisatellites not only show high-frequency spontaneous mutation in the germline, but also appear to be very sensitive to mutation induction by ionizing radiation, both in experimentally irradiated mice and in human populations exposed following the Chernobyl disaster; the mechanisms of mutation induction by radiation remain enigmatic.

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