Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy

2002 ◽  
pp. 67-83 ◽  
Author(s):  
Asla Pitkänen ◽  
Jari Nissinen ◽  
Jaak Nairismägi ◽  
Katarzyna Lukasiuk ◽  
Olli H.J. Gröhn ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Neuronal Damage ◽  
Spontaneous Seizures

Neuronal Cell Death in a Rat Model for Mesial Temporal Lobe Epilepsy Is Induced by the Initial Status Epilepticus and Not by Later Repeated Spontaneous Seizures

Epilepsia ◽  
2003 ◽  
Vol 44 (5) ◽  
pp. 647-658 ◽  
Author(s):  
Jan A. Gorter ◽  
Pedro M. Gonçalves Pereira ◽  
Erwin A. Van Vliet ◽  
Eleonora Aronica ◽  
Fernando H. Lopes Da Silva ◽  
...  
Keyword(s):  
Cell Death ◽  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mesial Temporal Lobe Epilepsy ◽  
Spontaneous Seizures ◽  
Mesial Temporal Lobe

Prophylactic treatment with melatonin after status epilepticus: Effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy

2013 ◽  
Vol 27 (1) ◽  
pp. 174-187 ◽  
Author(s):  
Jana Tchekalarova ◽  
Zlatina Petkova ◽  
Daniela Pechlivanova ◽  
Slavianka Moyanova ◽  
Lidia Kortenska ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Prophylactic Treatment ◽  
Neuronal Damage ◽  
Behavioral Changes

scholarly journals Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy

Epilepsia ◽  
2013 ◽  
Vol 54 (4) ◽  
pp. 589-595 ◽  
Author(s):  
Linda Holtman ◽  
Erwin A. van Vliet ◽  
Eleonora Aronica ◽  
Diana Wouters ◽  
Wytse J. Wadman ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Blood Plasma ◽  
Temporal Lobe ◽  
Rat Model ◽  
Inflammation Markers

scholarly journals Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Hui Huang ◽  
Guiyun Cui ◽  
Hai Tang ◽  
Lingwen Kong ◽  
Xiaopeng Wang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Cell Apoptosis ◽  
Neuronal Damage ◽  
Luciferase Reporter ◽  
Caspase 9 ◽  
Notch 1 ◽  
Expression Levels ◽  
Gene Assay

AbstractThis study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by intraperitoneal injection of lithium chloride-pilocarpine. These model rats were injected intracerebroventricularly with an miRNA-146a inhibitor and Notch-1 siRNA. Then, neuronal damage and cell apoptosis in the cornu ammonis (CA) 1 and 3 regions of the hippocampus were assessed. SOD and MDA levels in the hippocampus were detected by chromatometry, and IL-1β, IL-6, and IL-18 levels were detected by ELISA. Then, we evaluated the expression levels of caspase-9, GFAP, Notch-1, and Hes-1 in the hippocampus. The interaction between Notch-1 and miRNA-146a was assessed by a dual luciferase reporter gene assay. A rat model of TLE was successfully established, which exhibited significantly increased miRNA-146a expression in the hippocampus. Silencing of miRNA-146a significantly alleviated the neuronal damage and cell apoptosis in the CA1 and CA3 regions of the hippocampus in TLE rats and decreased MDA, IL-1β, IL-6, and IL-18 levels and increased SOD levels in the hippocampus of TLE rats. In addition, silencing of miRNA-146a significantly decreased the expression levels of caspase-9, GFAP, Notch-1, and Hes-1 in the hippocampus of TLE rats. Notch-1 was identified as a target of miRNA-146a and silencing of Notch-1 aggravated the neuronal damage in the CA1 and CA3 regions. Silencing of miRNA-146a alleviated the neuronal damage in the hippocampus of TLE rats by down-regulating Notch-1.

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