Are Illness Concepts a Powerful Predictor of Adherence to Prophylactic Treatment in Bipolar Disorder?

2006 ◽  
Vol 2006 ◽  
pp. 220-221
Author(s):  
J.C. Ballenger
Keyword(s):  
Bipolar Disorder ◽  
Prophylactic Treatment ◽  
Powerful Predictor ◽  
Illness Concepts

scholarly journals Prophylaxis Latency and Outcome in Bipolar Disorders

2003 ◽  
Vol 48 (7) ◽  
pp. 449-457 ◽  
Author(s):  
Christopher Baethge ◽  
Leonardo Tondo ◽  
Irene M Bratti ◽  
Tom Bschor ◽  
Michael Bauer ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Treatment Response ◽  
Prophylactic Treatment ◽  
Bipolar Disorders ◽  
Mood Stabilizer ◽  
Adult Patients ◽  
Apparent Reduction

Objective: To analyze new and reviewed findings to evaluate relations between treatment response and latency from onset of bipolar disorder (BD) to the start of mood-stabilizer prophylaxis. Method: We analyzed our own new data and added findings from research reports identified by computerized searching. Results: We found 11 relevant studies, involving 1485 adult patients diagnosed primarily with BD. Reported latency to prophylaxis averaged 9.6 years (SD 1.3), and follow-up in treatment averaged 5.4 years (SD 3.1). Greater illness intensity and shorter treatment latency were closely associated, resulting in a greater apparent reduction in morbidity with earlier treatment. However, this finding was not sustained after correction for pretreatment morbidity, and treatment latency did not predict morbidity during treatment. Therefore, assessments based on improvement with treatment, or without correction for pretreatment morbidity, can be misleading. Conclusions: Available evidence does not support the proposal that delayed prophylaxis may limit response to prophylactic treatment in BD and related disorders.

Who Responds to Prophylactic Lithium Therapy?

1993 ◽  
Vol 163 (S21) ◽  
pp. 20-26 ◽  
Author(s):  
M. T. Abou-Saleh
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Bipolar Affective Disorder ◽  
Positive Family History ◽  
Specific Treatment ◽  
Predictors Of Outcome ◽  
Powerful Predictor ◽  
Bipolar Illness ◽  
History Of ◽  
Psychotic Features

The search for predictors of outcome has not been particularly rewarding, and the use of lithium remains empirical: a trial of lithium is the most powerful predictor of outcome. However, lithium is a highly specific treatment for bipolar disorder. In non-bipolar affective disorder, factors of interest are correlates of bipolar disorder: mood-congruent psychotic features, retarded-endogenous profile, cyclothymic personality, positive family history of bipolar illness, periodicity, and normality between episodes of illness.

Depot Antipsychotics in the Prophylaxis of Bipolar Affective Disorder

1994 ◽  
Vol 165 (6) ◽  
pp. 827-829 ◽  
Author(s):  
R. Littlejohn ◽  
F. Leslie ◽  
J. Cookson
Keyword(s):  
Bipolar Disorder ◽  
British Journal ◽  
Affective Disorder ◽  
Antipsychotic Drugs ◽  
Prophylactic Treatment ◽  
Bipolar Affective Disorder ◽  
Manic Depressive ◽  
Depot Antipsychotic ◽  
Depot Antipsychotics ◽  
Depot Medication

BackgroundThe efficacy of depot antipsychotic drugs in the prophylaxis of bipolar affective disorder was investigated.MethodLife charts were constructed for 18 outpatients with bipolar disorder receiving prophylactic treatment with depot medication. The durations of affective episodes were compared during periods on or off medication.ResultsThe subjects suffered fewer relapses and spent significantly less time in hospital (P = 0.001) for treatment of manic, depressive and mixed affective illness during treatment with depot antipsychotics.ConclusionsDepot antipsychotic medication may be a useful prophylactic treatment for certain patients with bipolar affective disorder.British Journal of Psychiatry (1994), 165, 827–829

Lithium in Depression: A Review of the Antidepressant and Prophylactic Effects of Lithium

1987 ◽  
Vol 21 (3) ◽  
pp. 356-365 ◽  
Author(s):  
Gordon F. Johnson
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Tricyclic Antidepressants ◽  
Prophylactic Treatment ◽  
Combined Treatment ◽  
Current Evidence ◽  
Antidepressant Effect ◽  
Therapeutic Effects ◽  
Antidepressant Response ◽  
Drug Of Choice

The therapeutic effects of lithium in depression are reviewed. The acute antidepressant effect of lithium alone is neither as impressive nor as predictable as its antimanic action, nor is it equivalent to that of tricyclic antidepressants. In patients who are ‘refractory’ to tricyclics or monoamine oxidase inhibitors, combined treatment with lithium may augment antidepressant response. Lithium is an effective prophylactic treatment in both unipolar and bipolar disorder and in the latter is the drug of choice. Aspects of monitoring, such as range of therapeutic plasma levels, dosage regimen and adverse effects, are discussed. Current evidence suggests that, in patients who fail to respond to lithium or are unable to tolerate side-effects, carbamazepine should be considered.

scholarly journals Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder

2007 ◽  
Vol 9 (3) ◽  
pp. 325-332 ◽  
Keyword(s):  
Bipolar Disorder ◽  
Drug Treatment ◽  
Life Events ◽  
Clinical Setting ◽  
Prophylactic Treatment ◽  
Stressful Life Events ◽  
Controlled Trials ◽  
Daily Routines ◽  
Social Rhythms ◽  
Social Rhythm

Bipolar disorder is characterized by frequent recurrences, often related to noncompliance with drug treatment, stressful life events, and disruptions in social rhythms. Interpersonal and social rhythm therapy (IPSRT) was designed to directly address these problem areas. This article discusses the circadian basis of IPSRT and the importance of stable daily routines in the maintenance of the euthymic state, as well as the two large controlled trials which empirically support this intervention. The authors discuss the advantages of IPSRT as an acute intervention, as well as a prophylactic treatment for both bipolar I and II disorder. Using a case example, the authors describe how IPSRT is implemented in a clinical setting, detailing the therapeutic methods and processes involved.

Sign in / Sign up

Export Citation Format

Share Document