Chemokine receptor 3 mobilizes to the surface of human mast cells in response to IgE-mediated activation and potentiates their generation of IL-13 and IL-4

2002 ◽  
Vol 109 (1) ◽  
pp. S69-S69 ◽  
Author(s):  
KS Price ◽  
EA Mellor ◽  
DS Friend ◽  
N De Jesus ◽  
Joshua A Boyce
Keyword(s):  
Mast Cells ◽  
Chemokine Receptor ◽  
Human Mast Cells ◽  
Ige Mediated

scholarly journals IgE mediated release of 3H-5HT from human mast cells (LAD cells)

2005 ◽  
Vol 115 (2) ◽  
pp. S260
Author(s):  
Y. Wu ◽  
D. Metcalfe ◽  
A. Kirshenbaum
Keyword(s):  
Mast Cells ◽  
Human Mast Cells ◽  
Ige Mediated

CC Chemokine Receptor 3 Mobilizes to the Surface of Human Mast Cells and Potentiates Immunoglobulin E–Dependent Generation of Interleukin 13

2003 ◽  
Vol 28 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Kursteen S. Price ◽  
Daniel S. Friend ◽  
Elizabeth A. Mellor ◽  
Nidia De Jesus ◽  
Gerald F. M. Watts ◽  
...  
Keyword(s):  
Mast Cells ◽  
Chemokine Receptor ◽  
Immunoglobulin E ◽  
Cc Chemokine ◽  
Interleukin 13 ◽  
Human Mast Cells

scholarly journals Cross-Talk Between Human Mast Cells and Epithelial Cells By IgE-Mediated Periostin Production in Eosinophilic Nasal Polyps

2016 ◽  
Vol 137 (2) ◽  
pp. AB186 ◽  
Author(s):  
Dae Woo Kim ◽  
Marianna Kulka ◽  
A Ra Jo ◽  
Kyung Mi Eun ◽  
Narcy Arizmendi ◽  
...  
Keyword(s):  
Mast Cells ◽  
Epithelial Cells ◽  
Cross Talk ◽  
Nasal Polyps ◽  
Human Mast Cells ◽  
Ige Mediated

Mechanisms Of Non-IgE-Mediated Uptake Of Antigen By Human Mast Cells

2014 ◽  
Vol 133 (2) ◽  
pp. AB60
Author(s):  
Brant Ward ◽  
Sahar Lotfi-Emran ◽  
Lawrence B. Schwartz
Keyword(s):  
Mast Cells ◽  
Human Mast Cells ◽  
Ige Mediated

scholarly journals Mast cells and mastocytosis

Blood ◽  
2008 ◽  
Vol 112 (4) ◽  
pp. 946-956 ◽  
Author(s):  
Dean D. Metcalfe
Keyword(s):  
Mast Cells ◽  
Kinase Inhibitors ◽  
Allergic Inflammation ◽  
Host Responses ◽  
High Affinity ◽  
Human Mast Cells ◽  
Proinflammatory Mediators ◽  
High Affinity Receptor ◽  
Ige Mediated ◽  
Affinity Receptor

Abstract Mast cells have been recognized for well over 100 years. With time, human mast cells have been documented to originate from CD34+ cells, and have been implicated in host responses in both innate and acquired immunity. In clinical immunology, they are recognized for their central role in IgE-mediated degranulation and allergic inflammation by virtue of their expression of the high-affinity receptor for IgE and release of potent proinflammatory mediators. In hematology, the clinical disease of mastocytosis is characterized by a pathologic increase of mast cells in tissues, often associated with mutations in KIT, the receptor for stem cell factor. More recently, and with increased understanding of how human mast cells are activated through receptors including the high-affinity receptor for IgE and KIT, specific tyrosine kinase inhibitors have been identified with the potential to interrupt signaling pathways and thus limit the proliferation of mast cells as well as their activation through immunoglobulin receptors.

Expression of the Chemokine Receptor CCR3 on Human Mast Cells

2001 ◽  
Vol 124 (1-3) ◽  
pp. 146-150 ◽  
Author(s):  
Amato de Paulis ◽  
Francesco Annunziato ◽  
Luisa Di Gioia ◽  
Sergio Romagnani ◽  
Maria Carfora ◽  
...  
Keyword(s):  
Mast Cells ◽  
Chemokine Receptor ◽  
Human Mast Cells ◽  
Chemokine Receptor Ccr3
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