Myocardial blood-flow response during mental stress in patients with coronary artery disease

The Lancet ◽  
2000 ◽  
Vol 356 (9226) ◽  
pp. 310-311 ◽  
Author(s):  
James A Arrighi ◽  
Matthew Burg ◽  
Ira S Cohen ◽  
Alexander H Kao ◽  
Steven Pfau ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Mental Stress ◽  
Blood Flow Response ◽  
Flow Response ◽  
Artery Disease

scholarly journals Myocardial blood flow response to isometric (handgrip) and treadmill exercise in coronary artery disease.

Circulation ◽  
1975 ◽  
Vol 51 (1) ◽  
pp. 126-131 ◽  
Author(s):  
D K Lowe ◽  
D A Rothbaum ◽  
P L McHenry ◽  
B C Corya ◽  
S B Knoebel
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Treadmill Exercise ◽  
Isometric Handgrip ◽  
Blood Flow Response ◽  
Flow Response ◽  
Artery Disease

scholarly journals Caffeine Impairs Myocardial Blood Flow Response to Physical Exercise in Patients with Coronary Artery Disease as well as in Age-Matched Controls

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5665 ◽  
Author(s):  
Mehdi Namdar ◽  
Tiziano Schepis ◽  
Pascal Koepfli ◽  
Oliver Gaemperli ◽  
Patrick T. Siegrist ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Physical Exercise ◽  
Myocardial Blood Flow ◽  
Blood Flow Response ◽  
Flow Response ◽  
Artery Disease

scholarly journals Regulation of myocardial blood flow response to mental stress in healthy individuals

2000 ◽  
Vol 278 (2) ◽  
pp. H360-H366 ◽  
Author(s):  
Heiko Schöder ◽  
Daniel H. Silverman ◽  
Roxana Campisi ◽  
James W. Sayre ◽  
Michael E. Phelps ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Mental Stress ◽  
Healthy Individuals ◽  
Cardiac Work ◽  
Coronary Vasomotion ◽  
Artery Disease ◽  
Induced Changes

Mental stress testing has been proposed as a noninvasive tool to evaluate endothelium-dependent coronary vasomotion. In patients with coronary artery disease, mental stress can induce myocardial ischemia. However, even the determinants of the physiological myocardial blood flow (MBF) response to mental stress are poorly understood. Twenty-four individuals (12 males/12 females, mean age 49 ± 13 yr, range 31–74 yr) with a low likelihood for coronary artery disease were studied. Serum catecholamines, cardiac work, and MBF (measured quantitatively with N-13 ammonia and positron emission tomography) were assessed. During mental stress (arithmetic calculation) MBF increased significantly from 0.70 ± 0.14 to 0.92 ± 0.21 ml ⋅ min−1⋅ g−1( P < 0.01). Mental stress caused significant increases ( P < 0.01) in serum epinephrine (26 ± 16 vs. 42 ± 17 pg/ml), norepinephrine (272 ± 139 vs. 322 ± 136 pg/ml), and cardiac work [rate-pressure product (RPP) 8,011 ± 1,884 vs. 10,416 ± 2,711]. Stress-induced changes in cardiac work were correlated with changes in MBF ( r = 0.72; P < 0.01). Multiple-regression analysis revealed stress-induced changes in the RPP as the only significant ( P = 0.0001) predictor for the magnitude of mental stress-induced increases in MBF in healthy individuals. Data from this group of healthy individuals should prove useful to investigate coronary vasomotion in individuals at risk for or with documented coronary artery disease.

Redistribution of Myocardial Blood Flow With Topical Nitroglycerin in Patients With Coronary Artery Disease

Circulation ◽  
1995 ◽  
Vol 91 (5) ◽  
pp. 1381-1388 ◽  
Author(s):  
Ernest L. Fallen ◽  
Claude Nahmias ◽  
Anita Scheffel ◽  
Geoff Coates ◽  
Rob Beanlands ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Artery Disease ◽  
Topical Nitroglycerin

Low coronary flow relative to myocardial mass predicts heart failure in symptomatic hypertensive patients with no obstructive coronary artery disease

2021 ◽  
Author(s):  
Jenifer M Brown ◽  
Wunan Zhou ◽  
Brittany Weber ◽  
Sanjay Divakaran ◽  
Leanne Barrett ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Obstructive Coronary Artery Disease ◽  
Mass Ratio ◽  
Metabolic Demand ◽  
Myocardial Mass ◽  
Lv Mass ◽  
Artery Disease

Abstract Aims The transition from hypertension to heart failure (HF) remains poorly understood. We hypothesized that insufficient perfusion to match global metabolic demand, reflected by a low ratio of myocardial blood flow to global myocardial mass, may be a HF risk marker. Methods and results A retrospective cohort (n = 346) of patients with hypertension who underwent clinical positron emission tomography (PET) myocardial perfusion imaging for chest pain and/or dyspnoea at Brigham and Women’s Hospital (Boston, MA, USA) were studied. Patients without obstructive coronary artery disease by history or PET perfusion (summed stress score &lt;3), HF, cardiomyopathy, or ejection fraction (EF) &lt;40% were followed for HF hospitalization (primary outcome), all-cause death, and their composite. Myocardial blood flow, left ventricular (LV) mass, volumes, and EF were obtained from PET, and a ‘flow/mass ratio’ was determined as hyperaemic myocardial blood flow over LV mass indexed to body surface area. A lower flow/mass ratio was independently associated with larger end-diastolic (β = −0.44, P &lt; 0.001) and end-systolic volume (β = −0.48, P &lt; 0.001) and lower EF (β = 0.33, P &lt; 0.001). A flow/mass ratio below the median was associated with an adjusted hazard ratio of 2.47 [95% confidence interval (CI) 1.24–4.93; P = 0.01] for HF hospitalization, 1.95 (95% CI 1.12–3.41; P = 0.02) for death, and 2.20 (95% CI 1.39–3.49; P &lt; 0.001) for the composite. Conclusion An integrated physiological measure of insufficient myocardial perfusion to match global metabolic demand identifies subclinical hypertensive heart disease and elevated risk of HF and death in symptomatic patients with hypertension but without flow-limiting coronary artery disease.

Effect of sublingually administered nitroglycerin on regional myocardial blood flow in patients with coronary artery disease

1977 ◽  
Vol 39 (5) ◽  
pp. 672-678 ◽  
Author(s):  
Peter F. Cohn ◽  
Denis Maddox ◽  
B. Leonard Holman ◽  
John E. Markis ◽  
Douglass F. Adams ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Regional Myocardial Blood Flow ◽  
Artery Disease ◽  
Regional Myocardial Blood

13N-ammonia PET/CT stress myocardial blood flow compared to fractional flow reserve in coronary artery disease

2020 ◽  
Vol 41 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Jouke J. Boer ◽  
Johan J.J.S. Kappelhof ◽  
Friso M. van der Zant ◽  
Maurits Wondergem ◽  
Hans(J) B.R.M. de Swart ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stress Myocardial Blood Flow ◽  
Pet Ct ◽  
Artery Disease
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