CALCIUM INFUSION IN THE DIAGNOSIS OF PRIMARY HYPERPARATHYROIDISM

The Lancet ◽  
1972 ◽  
Vol 299 (7750) ◽  
pp. 578-579
Keyword(s):  
Primary Hyperparathyroidism ◽  
Calcium Infusion

Calcium infusion test in primary hyperparathyroidism- sensitivity of calcium sensing receptor, possible new theories?

2019 ◽  
Author(s):  
Emir Muzurovic ◽  
Sandra Pekic ◽  
Marina Djurovic ◽  
Dragana Miljic ◽  
Marko Stojanovic ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Infusion Test ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Calcium Infusion

Calcitonin response to calcium infusion test in patients with primary hyperparathyroidism

2019 ◽  
Author(s):  
Zvezdana Jemuovic ◽  
Marina Djurovic ◽  
Sandra Pekic ◽  
Dragana Miljic ◽  
Marko Stojanovic ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Infusion Test ◽  
Calcium Infusion

Decreased plasma calcitonin response to a calcium clamp in primary hyperparathyroidism

1985 ◽  
Vol 108 (3) ◽  
pp. 372-376 ◽  
Author(s):  
O. Tørring ◽  
E. Bucht ◽  
H. E. Sjöberg
Keyword(s):  
Primary Hyperparathyroidism ◽  
Healthy Subjects ◽  
Control Group ◽  
Terminal Amino Acid ◽  
Group 13 ◽  
Basal Plasma ◽  
Calcium Infusion ◽  
Mild Primary Hyperparathyroidism ◽  
Terminal Amino ◽  
Carboxy Terminal

Abstract. In order preoperatively to evaluate the calcium induced plasma calcitonin (CT) response in patients with mild primary hyperparathyroidism (PHPT), 7 postmenopausal (PM) females with PHPT and 14 PM healthy subjects underwent a 2 h calcium infusion. The infusions were performed by means of the 'calcium clamp' technique previously described by us in order to obtain an identical calcium stimulus in all subjects. Immunoreactive calcitonin (iCT) was determined by means of a sensitive RIA utilizing rabbit antibodies directed against the carboxy-terminal amino acid sequence of the CT molecule. All patients with PHPT had normal basal plasma iCT levels: 10 ± 5 pg-eq/ml (mean ± sd) as a group and not different from the control group: 13 ± 5 pg-eq/ml. In the control group significantly increased plasma iCT was seen at 30, 60, 90 and 120 min in contrast to that of the PHPT group where a blunted response was observed. The results indicate a diminished CT reserve in these patients which may imply an impaired defence against the PTH mediated bone resorption seen in patients with PHPT.

Effects of hypercalcemia and parathyroid hormone on blood pressure in normal and renal-failure rats

1986 ◽  
Vol 250 (5) ◽  
pp. F924-F929 ◽  
Author(s):  
K. Iseki ◽  
S. G. Massry ◽  
V. M. Campese
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Mean Arterial Pressure ◽  
Primary Hyperparathyroidism ◽  
Serum Calcium ◽  
Induced Hypertension ◽  
Calcium Infusion ◽  
Permissive Role

Hypertension is common in primary hyperparathyroidism, but the mechanisms are not clear. Significant hypercalcemia induces elevation in blood pressure (BP), whereas excessive parathyroid hormone (PTH) lowers BP. However, in chronic renal failure (CRF) and secondary hyperparathyroidism, the hypercalcemia-induced hypertension is more severe. We examined the interaction between PTH and calcium on BP in normal rats and in those with CRF. Calcium caused a dose-related rise in serum calcium and a rise in mean arterial pressure (MAP). For a comparable rise in serum calcium, the increment in MAP in parathyroidectomized (PTX) rats (7 +/- 3 mmHg) was significantly lower (P less than 0.05) than in sham PTX rats (19 +/- 7.3 mmHg). In PTX rats receiving PTH, the MAP response to calcium infusion (17 +/- 2.4 mmHg) was similar to that in the sham PTX rats. The infusion of similar amounts of calcium in CRF rats caused a greater rise in serum calcium. In CRF-PTX rats, the changes in MAP during calcium infusion were significantly lower (P less than 0.05) than in CRF-sham PTX animals, despite similar rise in serum calcium. For a comparable rise in serum calcium, the rise in MAP in CRF rats was greater than in normal rats. These data suggest that the presence of PTH plays an important permissive role for the hypertensive action of the hypercalcemia.

CALCIUM INFUSION IN THE DETECTION OF BONE DISEASE IN PRIMARY HYPERPARATHYROIDISM

1962 ◽  
Vol 40 (3_Suppl) ◽  
pp. S173
Author(s):  
Heinrich G. Haas ◽  
John J. Canary ◽  
Laurence H. Kyle ◽  
Daniel H. Mintz
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Disease ◽  
Calcium Infusion

THE CALCIUM-INFUSION-HYDROXYPROLINE TEST

1968 ◽  
Vol 58 (4) ◽  
pp. 578-580 ◽  
Author(s):  
L. Skovsted ◽  
M. Kristensen ◽  
K. Siersbæk-Nielsen ◽  
J. Mølholm Hansen
Keyword(s):  
Primary Hyperparathyroidism ◽  
Normal Subjects ◽  
Urinary Hydroxyproline ◽  
Calcium Infusion ◽  
Intravenous Calcium

ABSTRACT Urinary hydroxyproline was measured before, during, and after intravenous calcium-infusion in 5 normal subjects and in 4 patients with parathyroid adenomata. The results show that primary hyperparathyroidism cannot be diagnosed by means of a calcium-infusion-hydroxyproline test.

Sign in / Sign up

Export Citation Format

Share Document