Is the antigenic nonapeptide of the HSP60 of Klebsiella pneumoniae the triggering factor in ankylosing spondylitis?

1997 ◽  
Vol 56 ◽  
pp. 306
Author(s):  
E. García-Latorre ◽  
M.E. Cancino-Díaz ◽  
E. Curiel-Quesada ◽  
M.L. Domínguez-López ◽  
L. Jiménez-Zamudio
Keyword(s):  
Ankylosing Spondylitis ◽  
Klebsiella Pneumoniae ◽  
Triggering Factor

scholarly journals The Link between Ankylosing Spondylitis, Crohn’s Disease,Klebsiella, and Starch Consumption

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Taha Rashid ◽  
Clyde Wilson ◽  
Alan Ebringer
Keyword(s):  
Crohn’S Disease ◽  
Ankylosing Spondylitis ◽  
Crohn's Disease ◽  
Klebsiella Pneumoniae ◽  
Dietary Intake ◽  
Therapeutic Effect ◽  
Hla B27 ◽  
Daily Dietary Intake ◽  
Pathological Lesions ◽  
Triggering Factor

Both ankylosing spondylitis (AS) and Crohn’s disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen,Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of theKlebsiellamicrobes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiellaantibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD.

scholarly journals Klebsiella pneumoniae and acute anterior uveitis in ankylosing spondylitis.

BMJ ◽  
1979 ◽  
Vol 1 (6160) ◽  
pp. 383-383 ◽  
Author(s):  
R Ebringer ◽  
D Cawdell ◽  
A Ebringer
Keyword(s):  
Ankylosing Spondylitis ◽  
Klebsiella Pneumoniae ◽  
Anterior Uveitis ◽  
Acute Anterior Uveitis

Iga Antibodies to Klebsiella Pneumoniae in Ankylosing Spondylitis

1983 ◽  
Vol 12 (3) ◽  
pp. 249-253 ◽  
Author(s):  
A. K. Trull ◽  
R. Ebringer ◽  
G. S. Panayi ◽  
D. Colthorpe ◽  
D. C. O. James ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Klebsiella Pneumoniae ◽  
Iga Antibodies
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