Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions

William Lewis

doi:10.1016/s0166-3542(03)00069-x

Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions

Antiviral Research ◽

10.1016/s0166-3542(03)00069-x ◽

2003 ◽

Vol 58 (3) ◽

pp. 189-197 ◽

Cited By ~ 44

Author(s):

William Lewis

Keyword(s):

Reverse Transcriptase ◽

Mitochondrial Dysfunction ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Clinical Questions ◽

Reverse Transcriptase Inhibitor

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Mitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy

Infectious Disease - Reverse Transcriptase Inhibitors in HIV/AIDS Therapy ◽

10.1007/978-1-59745-085-0_9 ◽

2007 ◽

pp. 267-279

Author(s):

William Lewis

Keyword(s):

Reverse Transcriptase ◽

Mitochondrial Dysfunction ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Reverse Transcriptase Inhibitor

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Antiviral Resistance of Biologic HIV-2 Clones Obtained From Individuals on Nucleoside Reverse Transcriptase Inhibitor Therapy

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/00126334-200009010-00002 ◽

2000 ◽

Vol 25 (1) ◽

pp. 11-18 ◽

Cited By ~ 24

Author(s):

Marchina E. van der Ende ◽

Christophe Guillon ◽

Patrick H. M. Boers ◽

Thoai Duong Ly ◽

Rob A. Gruters ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Antiviral Resistance ◽

Reverse Transcriptase Inhibitor

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Mitochondrial toxicity associated with nucleoside reverse transcriptase inhibitor therapy

Current Infectious Disease Reports ◽

10.1007/s11908-001-0094-4 ◽

2001 ◽

Vol 3 (6) ◽

pp. 553-560 ◽

Cited By ~ 4

Author(s):

Cecilia M. Shikuma ◽

Bruce Shiramizu

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Mitochondrial Toxicity ◽

Reverse Transcriptase Inhibitor

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No significant effect of uridine or pravastatin treatment for HIV lipoatrophy in men who have ceased thymidine analogue nucleoside reverse transcriptase inhibitor therapy: a randomized trial

HIV Medicine ◽

10.1111/j.1468-1293.2009.00817.x ◽

2010 ◽

Author(s):

A Calmy ◽

M Bloch ◽

H Wand ◽

C Delhumeau ◽

R Finlayson ◽

...

Keyword(s):

Reverse Transcriptase ◽

Randomized Trial ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Thymidine Analogue ◽

Reverse Transcriptase Inhibitor

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Indinavir did not increase the short-term risk of adverse cardiovascular events relative to nucleoside reverse transcriptase inhibitor therapy in four phase III clinical trials

AIDS ◽

10.1097/00002030-200108170-00020 ◽

2001 ◽

Vol 15 (12) ◽

pp. 1584-1586 ◽

Cited By ~ 13

Author(s):

Paul M. Coplan ◽

Alexander A. Nikas ◽

Randi Y. Leavitt ◽

Louise Doll ◽

Michael L. Nessly ◽

...

Keyword(s):

Clinical Trials ◽

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Cardiovascular Events ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Phase Iii ◽

Short Term ◽

Phase Iii Clinical Trials ◽

Reverse Transcriptase Inhibitor

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Peripheral Neuropathy Associated With Nucleoside Reverse Transcriptase Inhibitor Therapy

Infectious Disease - Reverse Transcriptase Inhibitors in HIV/AIDS Therapy ◽

10.1007/978-1-59745-085-0_8 ◽

2007 ◽

pp. 237-266

Author(s):

Bruce A. Cohen ◽

Russell Bartt

Keyword(s):

Peripheral Neuropathy ◽

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Reverse Transcriptase Inhibitor

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Reduction of mitochondrial DNA content and respiratory chain activity occurs in adipocytes within 6–12 months of commencing nucleoside reverse transcriptase inhibitor therapy

AIDS ◽

10.1097/00002030-200403260-00015 ◽

2004 ◽

Vol 18 (5) ◽

pp. 815-817 ◽

Cited By ~ 34

Author(s):

Emma Hammond ◽

David Nolan ◽

Ian James ◽

Cecily Metcalf ◽

Simon Mallal

Keyword(s):

Mitochondrial Dna ◽

Reverse Transcriptase ◽

Respiratory Chain ◽

Dna Content ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Mitochondrial Dna Content ◽

Respiratory Chain Activity ◽

Reverse Transcriptase Inhibitor

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Antiviral Resistance of Biologic HIV-2 Clones Obtained From Individuals on Nucleoside Reverse Transcriptase Inhibitor Therapy

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/00042560-200009010-00002 ◽

2000 ◽

pp. 11-18 ◽

Cited By ~ 3

Author(s):

Marchina E. van der Ende ◽

Christophe Guillon ◽

Patrick H. M. Boers ◽

Thoai Duong Ly ◽

Rob A. Gruters ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Antiviral Resistance ◽

Reverse Transcriptase Inhibitor

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Virologic and Immunologic Response to Nucleoside Reverse‐Transcriptase Inhibitor Therapy among Human Immunodeficiency Virus–Infected Infants and Children

The Journal of Infectious Diseases ◽

10.1086/314638 ◽

1999 ◽

Vol 179 (3) ◽

pp. 576-583 ◽

Cited By ~ 17

Author(s):

Paul E. Palumbo ◽

Claire Raskino ◽

Susan Fiscus ◽

Savita Pahwa ◽

Ted Schutzbank ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

Infants And Children ◽

Immunologic Response ◽

Immunodeficiency Virus ◽

Reverse Transcriptase Inhibitor

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Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial

The Lancet Infectious Diseases ◽

10.1016/s1473-3099(19)30036-2 ◽

2019 ◽

Vol 19 (3) ◽

pp. 253-264 ◽

Cited By ~ 39

Author(s):

Michael Aboud ◽

Richard Kaplan ◽

Johannes Lombaard ◽

Fujie Zhang ◽

José A Hidalgo ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Inhibitor Therapy ◽

First Line ◽

Open Label ◽

First Line Therapy ◽

Line Therapy ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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