Single-unit activity in the dorsomedial prefrontal cortex during the expression of discriminative bradycardia in rabbits

1991 ◽  
Vol 43 (1) ◽  
pp. 79-92 ◽  
Author(s):  
Charles M. Gibbs ◽  
D.A. Powell
Keyword(s):  
Prefrontal Cortex ◽  
Unit Activity ◽  
Single Unit ◽  
Single Unit Activity ◽  
Dorsomedial Prefrontal Cortex

Single unit activity during a Go/NoGo task in the “prefrontal cortex” of pigeons

1999 ◽  
Vol 839 (2) ◽  
pp. 263-278 ◽  
Author(s):  
T Kalt ◽  
B Diekamp ◽  
O Güntürkün
Keyword(s):  
Prefrontal Cortex ◽  
Unit Activity ◽  
Single Unit ◽  
Single Unit Activity

scholarly journals Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

2007 ◽  
Vol 2007 ◽  
pp. 1-9 ◽  
Author(s):  
Jinhwa Jang ◽  
Hee-Jin Ha ◽  
Yun Bok Kim ◽  
Young-Ki Chung ◽  
Min Whan Jung
Keyword(s):  
Prefrontal Cortex ◽  
Firing Rate ◽  
Medial Prefrontal Cortex ◽  
Unit Activity ◽  
Single Unit ◽  
Discharge Rate ◽  
Rate Change ◽  
Psychotic Symptoms ◽  
Single Unit Activity

To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.

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