Cloning and expression of a gene encoding Sm16, an anti-inflammatory protein from Schistosoma mansoni

2000 ◽  
Vol 108 (1) ◽  
pp. 101-108 ◽  
Author(s):  
K.V.N Rao ◽  
K Ramaswamy
2021 ◽  
Vol 22 (2) ◽  
pp. 488
Author(s):  
Young-Su Yi

Inflammation, an innate immune response that prevents cellular damage caused by pathogens, consists of two successive mechanisms, namely priming and triggering. While priming is an inflammation-preparation step, triggering is an inflammation-activation step, and the central feature of triggering is the activation of inflammasomes and intracellular inflammatory protein complexes. Flavonoids are natural phenolic compounds predominantly present in plants, fruits, and vegetables and are known to possess strong anti-inflammatory activities. The anti-inflammatory activity of flavonoids has long been demonstrated, with the main focus on the priming mechanisms, while increasing numbers of recent studies have redirected the research focus on the triggering step, and studies have reported that flavonoids inhibit inflammatory responses and diseases by targeting inflammasome activation. Rheumatic diseases are systemic inflammatory and autoimmune diseases that primarily affect joints and connective tissues, and they are associated with numerous deleterious effects. Here, we discuss the emerging literature on the ameliorative role of flavonoids targeting inflammasome activation in inflammatory rheumatic diseases.


2009 ◽  
Vol 63 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Erika Gustafsson ◽  
Cecilia Forsberg ◽  
Karin Haraldsson ◽  
Stina Lindman ◽  
Lill Ljung ◽  
...  

Neonatology ◽  
2006 ◽  
Vol 89 (3) ◽  
pp. 159-170 ◽  
Author(s):  
Thomas L. Miller ◽  
Beth N. Shashikant ◽  
Aprile L. Pilon ◽  
Richard A. Pierce ◽  
Thomas H. Shaffer ◽  
...  

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