scholarly journals PO-0901 2D solid-state array detectors: a technique for in-vivo dose verification at varying effective area

2019 ◽  
Vol 133 ◽  
pp. S477-S478
Author(s):  
G. Biasi ◽  
K. Utitsarn ◽  
M. Petasecca ◽  
M. Carolan ◽  
V.L. Perevertaylo ◽  
...  
2019 ◽  
Vol 20 (11) ◽  
pp. 88-94
Author(s):  
Kananan Utitsarn ◽  
Giordano Biasi ◽  
Nauljun Stansook ◽  
Ziyad A. Alrowaili ◽  
Marco Petasecca ◽  
...  

2015 ◽  
Vol 93 (3) ◽  
pp. 163-169 ◽  
Author(s):  
Bo Lan ◽  
Brandon A. Norris ◽  
Jeffrey C.-Y. Liu ◽  
Peter D. Paré ◽  
Chun Y. Seow ◽  
...  

Airway smooth muscle (ASM) plays a central role in the excessive narrowing of the airway that characterizes the primary functional impairment in asthma. This phenomenon is known as airway hyper-responsiveness (AHR). Emerging evidence suggests that the development and maintenance of ASM force involves dynamic reorganization of the subcellular filament network in both the cytoskeleton and the contractile apparatus. In this review, evidence is presented to support the view that regulation of ASM contraction extends beyond the classical actomyosin interaction and involves processes within the cytoskeleton and at the interfaces between the cytoskeleton, the contractile apparatus, and the extracellular matrix. These processes are initiated when the muscle is activated, and collectively they cause the cytoskeleton and the contractile apparatus to undergo structural transformation, resulting in a more connected and solid state that allows force generated by the contractile apparatus to be transmitted to the extracellular domain. Solidification of the cytoskeleton also serves to stiffen the muscle and hence the airway. Oscillatory strain from tidal breathing and deep inspiration is believed to be the counter balance that prevents hypercontraction and stiffening of ASM in vivo. Dysregulation of this balance could lead to AHR seen in asthma.


2018 ◽  
Vol 86 (2) ◽  
pp. 23 ◽  
Author(s):  
Yori Yuliandra ◽  
Erizal Zaini ◽  
Syofyan Syofyan ◽  
Wenny Pratiwi ◽  
Lidiya Putri ◽  
...  

2014 ◽  
Vol 66 (10) ◽  
pp. 1439-1450 ◽  
Author(s):  
Hamdy Abdelkader ◽  
Ossama Y Abdallah ◽  
Hesham Salem ◽  
Adam WG Alani ◽  
Raid G Alany

Author(s):  
O. S. Pavluchenko ◽  
О. L. Kukla

Solid-state ion selective transducers, as an alternative to the traditional liquid electrolyte-filled glass electrodes, are known for over four decades now, and find their use in various areas of industry and applied science, such as in vivo analysis of the ions activity in biological and medical research, monitoring of toxic and aggressive environments, and biosensors design. However, along with potential advantages — short response time, small size, chemical inertness and durability — solid-state devices also possess certain inherent drawbacks — namely intrinsic noise, drift and instability of sensing properties, and cross-sensitivity to various interfering environmental conditions — that inhibit their widespread acceptance. Further improvement of the fabrication technology and methodology of application of these devices is thus still an important practical task even today. This paper is a first part of the two-part work dedicated to the problem of compensating the temperature dependence of a solid-state ion selective transducer output. Specifically, presented work considers the possibility of using ion-selective field-effect transistors (ISFET) that serve as primary transducers in an ionometric device, as temperature sensors. This allows compensating the temperature dependence of ionometric signal without substantial complication of the ionometer structure, and eliminates the need to include a separate thermometric channel as part of the instrument. Ionometric and thermometric channels are combined into a unified measuring path, with the sensor functions separated in time. The ISFET operation modes are switched by changing polarity of the bias voltage, and thus direction of the current flowing through the sensor. The authors propose a corresponding secondary transducer structure and simplified schematic illustrating the implementation of its key components. The concept’s applicability is supported by the circuit simulation results. Some aspects of the practical implementation of the proposed concept will be presented further in the upcoming second part of the paper.


2019 ◽  
Vol 20 (3) ◽  
pp. 37-44 ◽  
Author(s):  
Savino Cilla ◽  
Anna Ianiro ◽  
Maurizio Craus ◽  
Pietro Viola ◽  
Francesco Deodato ◽  
...  

Author(s):  
Ming Yi ◽  
Hrishikesh V. Panchawagh ◽  
Roop L. Mahajan ◽  
Zhengjun Liu ◽  
S. Nahum Goldberg

RF ablation is an important technique in cancer treatment. It has been proposed that the effective area treated via RF ablation can be increased by increasing the local electrical conductivity. This is achieved by injection of NaCl solution into the tissue. For an accurate and effective RF ablation treatment using this new method, it is necessary to measure the local electrical conductivity, which varies spatially due to diffusion of sodium chloride. In this paper, we propose a micro probe to measure the local tissue electrical conductivity. The probe consists of two in-plane miniature electrodes separated by a small gap. When the electrodes are in contact with the tissue, the electrical resistance across them can be used to calculate the electrical conductivity. The probe is fabricated by standard photolithography techniques. The substrate material is polyimide and the electrodes are made of gold. A four-electrode probe is used to calibrate the new electrical conductivity micro probe using different concentrations of saline water. The resistance measurements are carried out using an impedance analyzer on different frequencies. The frequency of choice for RF ablation of tumors is 500k Hz and is the one selected for calibration and testing. The micro-probe calibration is then verified by measuring electrical conductivity of a phantom and comparing it with the result measured by the four-electrode probe. Finally, some in vivo tests are performed and the results are compared with literate data.


2005 ◽  
Vol 32 (6Part8) ◽  
pp. 1984-1984
Author(s):  
S Hui ◽  
P Alaei ◽  
P Higgins ◽  
B Gerbi

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