Effects of SI and SII electrical stimulation of formalin induced c-Fos expression in the trigeminal nucleus caudalis in the rat

1998 ◽  
Vol 31 ◽  
pp. S198
Author(s):  
Motohide Takemura ◽  
Atsutoshi Tsujio ◽  
Toyomi Shimada ◽  
Yoshio Shigenaga ◽  
Ryotaro Kuroda
Keyword(s):  
Electrical Stimulation ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Fos Expression ◽  
Stimulation Of

Possible Antimigraine Mechanisms of Action of the 5HT1F Receptor Agonist LY334370

Cephalalgia ◽  
1999 ◽  
Vol 19 (10) ◽  
pp. 851-858 ◽  
Author(s):  
S Shepheard ◽  
L Edvinsson ◽  
M Cumberbatch ◽  
D Williamson ◽  
G Mason ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Dura Mater ◽  
Receptor Agonist ◽  
Cerebral Arteries ◽  
Plasma Extravasation ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Nociceptive Reflex ◽  
Stimulation Of

This study investigated whether the selective 5HT1F receptor agonist LY334370 has other possible antimigraine mechanisms in addition to the proposed inhibition of dural plasma extravasation. LY334370 (up to 10−5 M) had no vasoconstrictor effects on human cerebral arteries in vitro. It had no effect (up to 10 mg kg−1, iv) on neurogenic vasodilation of dural blood vessels produced by electrical stimulation of the dura mater in anesthetized rats. Nor had it any effect (at 3 mg kg−1, iv) on the hyperalgesia produced by injection of carrageenan into the paw of conscious rats or on nociceptive reflex responses in the spinalized, decerebrate rabbit (up to 3 mg kg−1, iv), indicating that it has no general analgesic properties. However, it significantly inhibited activation of second-order neurons in the trigeminal nucleus caudalis produced by electrical stimulation of the dura mater in anesthetised rats at 3 mg kg−1, iv. These results provide evidence to suggest that LY334370 has a central mechanism of action in blocking the transmission of nociceptive impulses within the trigeminal nucleus caudalis and that this may represent a mechanism through which it has its antimigraine effect.

scholarly journals Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis

1999 ◽  
Vol 127 (3) ◽  
pp. 623-630 ◽  
Author(s):  
Dimos D Mitsikostas ◽  
Margarita Sanchez del Rio ◽  
Christian Waeber ◽  
Zhihong Huang ◽  
F Michael Cutrer ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Nmda Glutamate Receptors ◽  
Fos Expression

Effects of previous noxious stimulus applied to remote areas on noxious stimulus-evoked c-Fos expression in the rat trigeminal nucleus caudalis

2001 ◽  
Vol 39 (3) ◽  
pp. 293-298 ◽  
Author(s):  
Nahoko Nagamatsu ◽  
Tetsuya Ikeda ◽  
Ryuji Terayama ◽  
Tadashi Nakamura ◽  
Mikako Koganemaru ◽  
...  
Keyword(s):  
Noxious Stimulus ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Remote Areas ◽  
Fos Expression

Nitric Oxide Implicates c-Fos Expression in the Cuneate Nucleus Following Electrical Stimulation of the Transected Median Nerve

2011 ◽  
Vol 37 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Hsin-Ying Wang ◽  
Yi-Ju Tsai ◽  
Seu-Hwa Chen ◽  
Chi-Te Lin ◽  
June-Horng Lue
Keyword(s):  
Nitric Oxide ◽  
Electrical Stimulation ◽  
Median Nerve ◽  
Cuneate Nucleus ◽  
Fos Expression ◽  
Stimulation Of
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