Increased vascular expression of endothelin-1, with unaltered nitric oxide pathway, in fructose-fed hypertensive rats

2000 ◽  
Vol 50 ◽  
pp. 369-370
Author(s):  
Daeho Lee ◽  
Dongjin Chung ◽  
Minyoung Chung ◽  
Jongun Lee
Keyword(s):  
Nitric Oxide ◽  
Hypertensive Rats ◽  
Endothelin 1 ◽  
Nitric Oxide Pathway ◽  
Vascular Expression

Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats

Metabolism ◽  
2001 ◽  
Vol 50 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Dae Ho Lee ◽  
JongUn Lee ◽  
Dae Gill Kang ◽  
Yun Woong Paek ◽  
Dong Jin Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Hypertensive Rats ◽  
Endothelin 1 ◽  
Oxide Synthase

Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats

2001 ◽  
Vol 422 (1-3) ◽  
pp. 149-157 ◽  
Author(s):  
Naohiko Kobayashi ◽  
Yousuke Mori ◽  
Shin-ichiro Mita ◽  
Shigefumi Nakano ◽  
Tsutomu Kobayashi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hypertensive Rats ◽  
Extracellular Signal Regulated Kinase ◽  
Endothelin 1 ◽  
Extracellular Signal

scholarly journals Possible Involvement of Endothelin Peptides and L-Arginine-Nitric Oxide Pathway on the Effect of Endotoxin in the Rabbit Isolated Perfused Kidney

1994 ◽  
Vol 3 (3) ◽  
pp. 211-214 ◽  
Author(s):  
K. Özsan ◽  
R. K. Türker ◽  
Z. S. Ercan
Keyword(s):  
Nitric Oxide ◽  
Constant Pressure ◽  
Soluble Guanylate Cyclase ◽  
Enzyme Inhibitor ◽  
Perfusion Medium ◽  
Isolated Perfused Kidney ◽  
Endothelin 1 ◽  
Vasoconstrictor Effect ◽  
Nitric Oxide Pathway ◽  
Perfused Kidney

Escherichia coliendotoxin (LPS) when infused through the renal artery of the rabbit isolated perfused kidney prepared as constant pressure mode, caused a decrease in flow rate and kidney weight indicating its primary vasoconstrictor effect. This effect was predominant in kidneys from rabbits pretreated with LPS. Endothelin-1 at a concentration of 10−10M and big endothelin-1 at a concentration of 10−8M produced equal vasoconstrictor effects in kidney. Addition of endotheHn converting enzyme inhibitor, phosphoramidon, to the perfusion medium at a concentration of 10−6M caused a reduction in the effects of both LPS and big ET-1 without altering the vasoconstrictor effect of ETol. However, addition of methylene blue (10−5M), a soluble guanylate cyclase inhibitor and NG-nitro-L-arginine-methyl ester (10−6M) to the perfusion medium caused a potentiation in the vasoconstrictor effect of LPS. Indomethacin at a concentration of 10−6M did not alter the effect of LPS. These results were taken as evidence for the participation of endothelin peptides and the L-arginine-nitric oxide pathway in the effect ofLPS in rabbit isolated perfused kidney.

Vasodilator effect of human adrenomedullin(13 – 52) on hypertensive rats

1995 ◽  
Vol 73 (7) ◽  
pp. 1065-1069 ◽  
Author(s):  
Q. Tian ◽  
D. Zhao ◽  
D. Y. Tan ◽  
Y. T. Zhao ◽  
Q. H. Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Molecular Mechanisms ◽  
Hypotensive Activity ◽  
Hypertensive Rats ◽  
Hypotensive Action ◽  
Spontaneously Hypertensive ◽  
Endothelin 1 ◽  
In Vitro Effects

Human adrenomedullin (hADM) is a newly isolated peptide with hypotensive activity in normotensive rats. The objective of this study was to investigate the effect of hADM(13–52) on hypertensive animals. hADM(13–52) induced a dose-dependent decrease in the blood pressure of spontaneously hypertensive rats and renal hypertensive rats. This result suggests that hADM is a novel antihypertensive peptide. In isolated rat aortic arteries, hADM(13–52) produced nitric oxide dependent relaxation and inhibited endothelin 1 and angiotensin II release. These in vitro effects may represent the molecular mechanisms underlying the hypotensive action of hADM in vivo.Key words: human adrenomedullin, nitric oxide, endothelin 1, angiotensin II, hypertension.

Activity of the L-Arginine/Nitric Oxide Pathway and Endothelin-1 in Experimental Heart Failure

1994 ◽  
Vol 23 (6) ◽  
pp. 976 ◽  
Author(s):  
Georg Noll ◽  
Marcel R. Tschudi ◽  
Dragutin Novosel ◽  
Thomas F. Lüscher
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Endothelin 1 ◽  
Experimental Heart Failure ◽  
Nitric Oxide Pathway

Alterations of the Nitric Oxide Pathway in Cerebral Arteries from Spontaneously Hypertensive Rats

2002 ◽  
Vol 39 (3) ◽  
pp. 378-388 ◽  
Author(s):  
Ana M. Briones ◽  
María J. Alonso ◽  
Raquel Hernanz ◽  
Marta Miguel ◽  
Mercedes Salaices
Keyword(s):  
Nitric Oxide ◽  
Spontaneously Hypertensive Rats ◽  
Cerebral Arteries ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Nitric Oxide Pathway
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