628 RADIOFREQUENCY ABLATION VERSUS LASER ABLATION FOR THE TREATMENT OF SMALL HEPATOCELLULAR CARCINOMA: A RANDOMIZED CONTROLLED TRIAL

2011 ◽  
Vol 54 ◽  
pp. S254-S255 ◽  
Author(s):  
G.G. Pi Costanzo ◽  
R. Tortora ◽  
G. D'Adamo ◽  
A. Galeota Lanza ◽  
N. Carannante ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Randomized Controlled Trial ◽  
Radiofrequency Ablation ◽  
Laser Ablation ◽  
Controlled Trial ◽  
Small Hepatocellular Carcinoma ◽  
Randomized Controlled

scholarly journals Surgery Versus Radiofrequency Ablation for Small Hepatocellular Carcinoma: a Randomized Controlled Trial (SURF-Trial)

Liver Cancer ◽  
2021 ◽  
Author(s):  
Tadatoshi Takayama ◽  
Kiyoshi Hasegawa ◽  
Namiki Izumi ◽  
Masatoshi Kudo ◽  
Mitsuo Shimada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Randomized Controlled Trial ◽  
Radiofrequency Ablation ◽  
Controlled Trial ◽  
Interquartile Range ◽  
Small Hepatocellular Carcinoma ◽  
Randomized Controlled ◽  
Surgery Group ◽  
Primary Endpoints ◽  
Group Methods

Introduction: It remains unclear which of surgery or radiofrequency ablation (RFA) is the more effective treatment for small hepatocellular carcinoma (HCC). We aimed to compare survival between patients undergoing surgery (surgery group) and patients undergoing RFA (RFA group). Methods: We conducted a randomized controlled trial involving 49 institutions in Japan. Patients with Child-Pugh scores ≤ 7, largest HCC diameter ≤ 3 cm, and ≤ 3 HCC nodules were considered eligible. The co-primary endpoints were recurrence-free survival (RFS) and overall survival (OS). The current study reports the final result of RFS, and the follow-up of OS is still ongoing. Results: During 2009–2015, 308 patients were registered. After excluding ineligible patients, the surgery and RFA groups included 150 and 151 patients, respectively. Baseline factors did not differ significantly between the groups. In both groups, 90% of patients had solitary HCC. The median largest HCC diameter was 1.8 cm (interquartile range, 1.5–2.2 cm) in the surgery group and 1.8 cm (interquartile range, 1.5–2.3 cm) in the RFA group. The median procedure duration (274 versus 40 minutes, P<0.01) and the median duration of hospital stay (17 days versus 10 days, P<0.01) were longer in the surgery group than in the RFA group. RFS did not differ significantly between the groups as the median RFS was 3.5 (95% confidence interval [CI], 2.6–5.1) years in the surgery group and 3.0 (95% CI, 2.4–5.6) years in the RFA group (hazard ratio, 0.92; 95% CI, 0.67–1.25; P=0.58). Discussion/Conclusion: Our study did not show which of surgery or RFA is the better treatment option for small HCC.

A Randomized Controlled Trial of Radiofrequency Ablation With Ethanol Injection for Small Hepatocellular Carcinoma

2005 ◽  
Vol 129 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Shuichiro Shiina ◽  
Takuma Teratani ◽  
Shuntaro Obi ◽  
Shinpei Sato ◽  
Ryosuke Tateishi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Randomized Controlled Trial ◽  
Radiofrequency Ablation ◽  
Controlled Trial ◽  
Small Hepatocellular Carcinoma ◽  
Ethanol Injection ◽  
Randomized Controlled
Sign in / Sign up

Export Citation Format

Share Document