Removal of fibrosis-related genes identifies a hepatic gene expression signature that identifies canonical signaling pathways and is correlated with clinical outcomes in patients with primary sclerosing cholangitis

2020 ◽  
Vol 73 ◽  
pp. S483-S484
Author(s):  
Michael Trauner ◽  
Yevgeniy Gindin ◽  
Jing Zhu Zhou ◽  
Ryan Huss ◽  
Chuhan Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Clinical Outcomes ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Gene Expression Signature ◽  
Hepatic Gene Expression ◽  
Expression Signature

Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

2017 ◽  
Vol 26 (7) ◽  
pp. 1107-1113 ◽  
Author(s):  
Jennifer S. Ko ◽  
Balwir Matharoo-Ball ◽  
Steven D. Billings ◽  
Brian J. Thomson ◽  
Jean Y. Tang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malignant Melanoma ◽  
Clinical Outcomes ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Benign Nevi

Influence of maternal low protein diet during pregnancy on hepatic gene expression signature in juvenile female porcine offspring

2012 ◽  
Vol 57 (2) ◽  
pp. 277-290 ◽  
Author(s):  
Frank Döring ◽  
Kai Lüersen ◽  
Constance Schmelzer ◽  
Steffen Hennig ◽  
Iris S. Lang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Signature ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Hepatic Gene Expression ◽  
Juvenile Female ◽  
Expression Signature ◽  
Low Protein

scholarly journals Clinical validity of a gene expression signature in diagnostically uncertain neoplasms

2020 ◽  
Vol 17 (5) ◽  
pp. 361-371
Author(s):  
Loren E Clarke ◽  
Brent Mabey ◽  
Darl D Flake II ◽  
Stephanie Meek ◽  
David S Cassarino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clinical Outcomes ◽  
Gene Expression Signature ◽  
Test Accuracy ◽  
Test Results ◽  
Clinical Validity ◽  
Diagnostic Uncertainty ◽  
Expression Signature ◽  
High Diagnostic Accuracy ◽  
Diagnostic Certainty

Aim: Evaluate the accuracy of a 23-gene expression signature in differentiating benign nevi from melanoma by comparing test results with clinical outcomes. Materials & methods: Seven dermatopathologists blinded to gene expression test results and clinical outcomes examined 181 lesions to identify diagnostically uncertain cases. Participants independently recorded diagnoses and responses to questions quantifying diagnostic certainty. Test accuracy was determined through comparison with clinical outcomes (sensitivity and percent negative agreement). Results: Overall, 125 cases fulfilled criteria for diagnostic uncertainty (69.1%; 95% CI: 61.8–75.7%). Test sensitivity and percent negative agreement in these cases were 90.4% (95% CI: 79.0–96.8%) and 95.5% (95% CI: 87.3–99.1%), respectively. Conclusion: The 23-gene expression signature has high diagnostic accuracy in diagnostically uncertain cases when evaluated against clinical outcomes.

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