Diagnostic value of histochemical stains for copper in Wilson's disease

1998 ◽  
Vol 28 ◽  
pp. 134
Author(s):  
L. Pilloni ◽  
S. Lecca ◽  
P. Van Eyken ◽  
L. Demelia ◽  
G. Pilleri ◽  
...  
Keyword(s):  
Wilson’S Disease ◽  
Diagnostic Value ◽  
Wilson's Disease

Uneven distribution of hepatic copper concentration and diagnostic value of double-sample biopsy in Wilson's disease

2013 ◽  
Vol 48 (12) ◽  
pp. 1452-1458 ◽  
Author(s):  
Mauro Liggi ◽  
Claudia Mais ◽  
Mauro Demurtas ◽  
Orazio Sorbello ◽  
Enrico Demelia ◽  
...  
Keyword(s):  
Copper Concentration ◽  
Wilson’S Disease ◽  
Diagnostic Value ◽  
Wilson's Disease ◽  
Uneven Distribution ◽  
Hepatic Copper

scholarly journals Diagnostic Value of Ceruloplasmin in the Diagnosis of Pediatric Wilson's Disease

2015 ◽  
Vol 18 (3) ◽  
pp. 187 ◽  
Author(s):  
Jung Ah Kim ◽  
Hyun Jin Kim ◽  
Jin Min Cho ◽  
Seak Hee Oh ◽  
Beom Hee Lee ◽  
...  
Keyword(s):  
Wilson’S Disease ◽  
Diagnostic Value ◽  
Wilson's Disease

Assessment of Diagnostic Value of Serum Ceruloplasmin for Wilson’s Disease in Children

2021 ◽  
Author(s):  
Xinshuo Lu ◽  
Simin Li ◽  
Wen Zhang ◽  
Yunting Lin ◽  
Zhikun Lu ◽  
...  
Keyword(s):  
Gender Difference ◽  
Roc Curve ◽  
Wilson’S Disease ◽  
Diagnostic Value ◽  
Wilson's Disease ◽  
Genotypic Difference ◽  
Healthy Children ◽  
Cutoff Value ◽  
Serum Ceruloplasmin ◽  
And Gender

Abstract Background: Serum ceruloplasmin is one of the major diagnostic parameters for Wilson’s disease (WD). Age and gender difference of serum ceruloplasmin remain controversy. This study aims to assess diagnostic value of serum ceruloplasmin for WD in children. Methods: Serum ceruloplasmin were measured in 317 WD patients, 21 heterozygotes, 372 healthy control children and 154 non-WD patients. Receiver operating characteristic (ROC) curve was used to determine the diagnostic accuracy of serum ceruloplasmin for WD in children. Results: Among healthy controls, serum ceruloplasmin was mildly low in the infants younger than 6 months, and then presented around 26–33 mg/dl from 6 months to 15 years. Few (8.1%) of healthy children had serum ceruloplasmin < 20 mg/dL. Serum ceruloplasmin was 5.7 ± 4.7 mg/dl in WD patients, 25.6 ± 5.9 mg/dl in heterozygous carriers. Only 1.9% of WD patients had serum ceruloplasmin > 20 mg/dL. Serum ceruloplasmin had gender difference, higher in healthy boys than healthy girls, and also higher in asymptomatic WD boys than asymptomatic WD girls (p < 0.01, p < 0.05). Serum ceruloplasmin presented genotypic difference. WD patients with R778L homozygotes exhibited lower level of serum ceruloplasmin than WD patients without R778L (p < 0.05). The ROC curve revealed that serum ceruloplasmin, at a cutoff value of 16.8 mg/dL, had the highest AUC value (0.990) with a sensitivity of 95.9% and a specificity of 93.6%. Conclusions: Serum ceruloplasmin is a reliable diagnostic criteria for WD in children. Gender and genotypic difference of serum ceruloplasmin should be considered. The cutoff value of serum ceruloplasmin < 16.8 mg/dL may provide the highest accuracy for diagnosis of WD in children.

Diagnostic Value of Quantitative Hepatic Copper Determination in Patients With Wilson’s Disease

2005 ◽  
Vol 3 (8) ◽  
pp. 811-818 ◽  
Author(s):  
Peter Ferenci ◽  
Petra Steindl-Munda ◽  
Wolfgang Vogel ◽  
Wolfgang Jessner ◽  
Michael Gschwantler ◽  
...  
Keyword(s):  
Wilson’S Disease ◽  
Diagnostic Value ◽  
Wilson's Disease ◽  
Copper Determination ◽  
Hepatic Copper

Massive hepatic haemosiderosis in Wilson's disease

2000 ◽  
Vol 37 (2) ◽  
pp. 187-189 ◽  
Author(s):  
P Luca ◽  
L Demelia ◽  
S Lecca ◽  
R Ambu ◽  
G Faa
Keyword(s):  
Wilson’S Disease ◽  
Wilson's Disease
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