Induction of human cytomegalovirus (HCMV)-glycoprotein B (gB)-specific neutralizing antibody and phosphoprotein 65 (pp65)-specific cytotoxic T lymphocyte responses by naked DNA immunization

Vaccine ◽  
1999 ◽  
Vol 17 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Valeria Endresz ◽  
Laszlo Kari ◽  
Klara Berencsi ◽  
Csaba Kari ◽  
Zsofia Gyulai ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Neutralizing Antibody ◽  
Glycoprotein B ◽  
Dna Immunization ◽  
Naked Dna ◽  
Lymphocyte Responses

Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization

2002 ◽  
Vol 20 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Sang J. Ha ◽  
Jun Chang ◽  
Man K. Song ◽  
You S. Suh ◽  
Hyun T. Jin ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Dna Immunization ◽  
Lymphocyte Responses

Comparison of cytotoxic T lymphocyte responses induced by peptide or DNA immunization: Implications on immunogenicity and immunodominance

1997 ◽  
Vol 27 (3) ◽  
pp. 671-678 ◽  
Author(s):  
Antonella Vitiello ◽  
Alessandro Sette ◽  
Lunli Yuan ◽  
Peggy Farness ◽  
Scott Southwood ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Dna Immunization ◽  
Lymphocyte Responses

scholarly journals Protective Cytotoxic T Lymphocyte Responses Induced by DNA Immunization against Immunodominant and Subdominant Epitopes ofListeria monocytogenes Are Noncompetitive

2001 ◽  
Vol 69 (5) ◽  
pp. 3427-3430 ◽  
Author(s):  
Takashi Yamada ◽  
Hiroshi Uchiyama ◽  
Toshi Nagata ◽  
Masato Uchijima ◽  
Takafumi Suda ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Protective Immunity ◽  
Cytotoxic T Lymphocyte ◽  
Dna Immunization ◽  
Dna Encoding ◽  
Cell Responses ◽  
Oflisteria Monocytogenes ◽  
Lymphocyte Responses ◽  
Dominant Epitope ◽  
Subdominant Epitope

ABSTRACT Taking advantage of the fact that plasmid DNA encoding a single cytotoxic T lymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity.

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