Effect of cyclopropenoid fatty acids on the hepatic microsomal mixed-function-oxidase system and aflatoxin metabolism in rabbits

1982 ◽  
Vol 20 (4) ◽  
pp. 407-412 ◽  
Author(s):  
T.A. Eisele ◽  
P.M. Loveland ◽  
D.L. Kruk ◽  
T.R. Meyers ◽  
R.O. Sinnhuber ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Mixed Function Oxidase ◽  
Oxidase System ◽  
Cyclopropenoid Fatty Acids ◽  
Mixed Function Oxidase System ◽  
Microsomal Mixed Function Oxidase

Phenobarbitone-induced urinary excretions of D-glucaric acid and 6β-hydroxycortisol in man

1976 ◽  
Vol 54 (5) ◽  
pp. 778-782 ◽  
Author(s):  
A. N. Latham ◽  
P. Turner ◽  
C. Franklin ◽  
W. Maclay
Keyword(s):  
Normal Subjects ◽  
Mixed Function Oxidase ◽  
Glucaric Acid ◽  
Oxidase System ◽  
Mixed Function Oxidase System ◽  
Baseline Values ◽  
Microsomal Mixed Function Oxidase

The urinary excretions of D-glucaric acid and 6β-hydroxycortisol were determined in normal subjects before, during, and after 14 days treatment with placebo or phenobarbitone. The excretion of both metabolites was significantly potentiated by phenobarbitone and returned to baseline values 1 month after treatment was withdrawn. It was suggested that the determination of urinary D-glucaric acid reflects the activity of the hepatic microsomal mixed function oxidase system after the administration of an inducing agent such as phenobarbitone.

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