Enhancement of chemotherapeutic drug-induced apoptosis by a cyclooxygenase-2 inhibitor in hypopharyngeal carcinoma cells

2003 ◽  
Vol 201 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Jyh-Ping Peng ◽  
Li-Teh Liu ◽  
Hui-Chiu Chang ◽  
Wen-Chun Hung
Keyword(s):  
Cyclooxygenase 2 ◽  
Carcinoma Cells ◽  
Hypopharyngeal Carcinoma ◽  
Chemotherapeutic Drug ◽  
Drug Induced ◽  
Induced Apoptosis

Human U3 protein 14a plays an anti-apoptotic role in cancer cells

2017 ◽  
Vol 398 (11) ◽  
pp. 1247-1257 ◽  
Author(s):  
Teng Ma ◽  
Chenxi Lu ◽  
Yafei Guo ◽  
Chunfeng Zhang ◽  
Xiaojuan Du
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Protein Level ◽  
Tumor Therapy ◽  
Caspase Inhibitor ◽  
Chemotherapeutic Drug ◽  
Intrinsic Pathway ◽  
Down Regulation ◽  
Drug Induced ◽  
Induced Apoptosis

AbstractHuman U three protein 14a (hUTP14a) binds p53 and promotes p53 degradation. Here, we report that hUTP14a plays an anti-apoptotic role in tumor cells through a p53-independent pathway. Knockdown of hUTP14a activated the intrinsic pathway of apoptosis and sensitized tumor cells to chemotherapeutic drug-induced apoptosis. In addition, the protein level of hUTP14a decreased upon chemotherapeutic drug- or irradiation-induced apoptosis. Importantly, the decrease of hUTP14a during induced apoptosis was not blocked by pan-caspase inhibitor z-VAD-FMK, indicating that the down-regulation of hUTP14a is an upstream event in apoptosis. Furthermore, ectopically expressed hUTP14a protected tumor cells from chemotherapeutic drug-induced apoptosis. In summary, our data showed that hUTP14a protected tumor cells from chemotherapeutic drug-induced apoptosis and thus might possess a potential as a target for anti-tumor therapy.

scholarly journals Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

2011 ◽  
Vol 104 (8) ◽  
pp. 1278-1287 ◽  
Author(s):  
E W Duiker ◽  
A Meijer ◽  
A R M van der Bilt ◽  
G J Meersma ◽  
N Kooi ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Caspase 8 ◽  
Drug Induced ◽  
Ovarian Carcinoma Cells ◽  
Induced Apoptosis

scholarly journals Full-length p73α Represses Drug-induced Apoptosis in Small Cell Lung Carcinoma Cells

2005 ◽  
Vol 280 (40) ◽  
pp. 34159-34169 ◽  
Author(s):  
Ulrika Nyman ◽  
Agnieszka Sobczak-Pluta ◽  
Pinelopi Vlachos ◽  
Thomas Perlmann ◽  
Boris Zhivotovsky ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Carcinoma Cells ◽  
Full Length ◽  
Small Cell Lung ◽  
Drug Induced ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cells ◽  
Induced Apoptosis
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