Effects of melatonin on the activity of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in the homogenates of thyroid lobes in vitro collected from intact, sham-operated and hemithyroidectomized rats

1998 ◽  
Vol 52 (7-8) ◽  
pp. 333
Author(s):  
A. Gesing ◽  
E. Miszczak-Zaborska ◽  
E. Sewerynek ◽  
M. Karbownik ◽  
A. Lewiński ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Thymidine Phosphorylase ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth

Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene

1991 ◽  
Vol 11 (4) ◽  
pp. 2125-2132
Author(s):  
K Hagiwara ◽  
G Stenman ◽  
H Honda ◽  
P Sahlin ◽  
A Andersson ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Human Platelet ◽  
Angiogenic Factor ◽  
Transcription Start Sites ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth

Human platelet-derived endothelial cell growth factor (hPD-ECGF) is a novel angiogenic factor which stimulates endothelial cell growth in vitro and promotes angiogenesis in vivo. We report here the cloning and sequencing of the gene for hPD-ECGF and its flanking regions. This gene is composed of 10 exons dispersed over a 4.3-kb region. Its promoter lacks a TATA box and a CCAAT box, structures characteristic of eukaryotic promoters. Instead, six copies of potential Sp1-binding sites (GGGCGG or CCGCCC) were clustered just upstream of the transcription start sites. Southern blot analysis using genomic DNAs from several vertebrates suggested that the gene for PD-ECGF is conserved phylogenetically among vertebrates. The gene for hPD-ECGF was localized to chromosome 22 by analysis of a panel of human-rodent somatic cell hybrid lines.

Platelet-derived endothelial cell growth factor (Thymidine Phosphorylase) expression in lung cancer

1997 ◽  
Vol 181 (2) ◽  
pp. 196-199 ◽  
Author(s):  
Alexandra Giatromanolaki ◽  
Michael I. Koukourakis ◽  
Margaret Comley ◽  
Loukas Kaklamanis ◽  
Helen Turley ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Thymidine Phosphorylase ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth ◽  
Thymidine Phosphorylase Expression
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