Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery

1989 ◽  
Vol 3 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Kuniyoshi Tanaka ◽  
Motoshi Takao ◽  
Isao Yada ◽  
Hiroshi Yuasa ◽  
Minoru Kusagawa ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Coagulation And Fibrinolysis

Coagulation- and fibrinolysis-alterations in open heart surgery

2005 ◽  
Vol 53 (S 3) ◽  
Author(s):  
U Boeken ◽  
P Feindt ◽  
J Litmathe ◽  
E Gams
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Coagulation And Fibrinolysis

scholarly journals Normothermic versus hypothermic cardiopulmonary bypass in low-risk paediatric heart surgery: a randomised controlled trial

Heart ◽  
2018 ◽  
Vol 105 (6) ◽  
pp. 455-464 ◽  
Author(s):  
Massimo Caputo ◽  
Katie Pike ◽  
Sarah Baos ◽  
Karen Sheehan ◽  
Kathleen Selway ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Hospital Stay ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Postoperative Hospital Stay ◽  
Low Risk ◽  
Open Heart ◽  
Intubation Time ◽  
Organ Systems ◽  
Randomised Controlled

ObjectiveTo compare normothermic (35°C–36°C) versus hypothermic (28°C) cardiopulmonary bypass (CPB) in paediatric patients undergoing open heart surgery to test the hypothesis that normothermic CPB perfusion maintains the functional integrity of major organ systems leading to faster recovery.MethodsTwo single-centre, randomised controlled trials (known as Thermic-1 and Thermic-2, respectively) were carried out to compare the effectiveness and acceptability of normothermic versus hypothermic CPB in children with congenital heart disease undergoing open heart surgery. In both studies, the co-primary clinical outcomes were duration of inotropic support, intubation time and postoperative hospital stay.ResultsIn total, 200 participants were recruited; 59 to the Thermic-1 study and 141 to the Thermic-2 study. 98 patients received normothermic CPB and 102 patients received hypothermic CPB. There were no significant differences between the treatment groups for any of the co-primary outcomes: inotrope duration HR=1.01, 95% CI (0.72 to 1.41); intubation time HR=1.14, 95% CI (0.86 to 1.51); postoperative hospital stay HR=1.06, 95% CI (0.80 to 1.40). Differences favouring normothermia were found in urea nitrogen at 2 days geometric mean ratio (GMR)=0.86 95% CI (0.77 to 0.97); serum creatinine at 3 days GMR=0.89, 95% CI (0.81 to 0.98); urinary albumin at 48 hours GMR=0.32, 95% CI (0.14 to 0.74) and neutrophil gelatinase-associated lipocalin at 4 hours GMR=0.47, 95% CI (0.22 to 1.02), but not at other postoperative time points.ConclusionsNormothermic CPB is as safe and effective as hypothermic CPB and can be routinely adopted as a perfusion strategy in low-risk infants and children undergoing open heart surgery.Trial registration numberISRCTN93129502.

scholarly journals Comparing the Effects of Isoflurane-Sufentanil Anesthesia and Propofol-Sufentanil Anesthesia on Serum Cortisol Levels in Open Heart Surgery with Cardiopulmonary Bypass

2016 ◽  
Vol 6 (6) ◽  
Author(s):  
Abbas Sedighinejad ◽  
Vali Imantalab ◽  
Ali Mirmansouri ◽  
Bahram Naderi Nabi ◽  
Masoud Tarbiat ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Serum Cortisol ◽  
Open Heart ◽  
Cortisol Levels

scholarly journals Pre-operative and peri operative predictors of acute renal failure after cardiac surgery

2019 ◽  
Vol 6 (3) ◽  
pp. 756
Author(s):  
Praveen Dhaulta ◽  
Vikas Panwar
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Ejection Fraction ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Clinical Variable ◽  
Open Heart ◽  
Multiple Variables

Background: Acute kidney injury (AKI) is one of the most serious complications during the postoperative period of cardiac surgery. Multiple variables predict the ARF after cardiac surgery. Objective of this study was to evaluate the significance of pre and peri-operative variables which may help in predicting the chances of developing ARF after cardiac surgery.Methods: This study was an observational, prospective study conducted among patients who were scheduled to undergo open heart surgery under cardiopulmonary bypass.Results: In total, 50 patients who underwent open-heart surgery, ARF was seen in 5 patients, with the incidence rate of 10%. Acute renal failure was present in one patient with ejection fraction <35, 2 patients had ejection fraction between 35 to 50 and 2 patients with ejection fraction >50. It was seen in 4 patients with 1-2 hrs of cardiopulmonary bypass and in 1 patient with >2 hrs of cardiopulmonary bypass. ARF was also seen in 4 patients with hematocrit between 22-26% and in 1 patient with >26%.Conclusions: The study provided a clinical variable score that can predict ARF after open-heart surgery. The score enhances the accuracy of prediction by accounting for the effect of all major risk factors of ARF.

Effect of Albumin Addition to Cardiopulmonary Bypass Prime on Outcomes in Children Undergoing Open-Heart Surgery (EACPO Study)—A Randomized Controlled Trial

2020 ◽  
pp. 215013512095908
Author(s):  
Abdul Rauf ◽  
Reena K. Joshi ◽  
Neeraj Aggarwal ◽  
Mridul Agarwal ◽  
Manendra Kumar ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Cardiopulmonary Bypass ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Controlled Study ◽  
Risk Category ◽  
Open Heart ◽  
Oncotic Pressure ◽  
Randomized Controlled

Background: There is a paucity of literature regarding the association of high oncotic priming solutions for pediatric cardiopulmonary bypass (CPB) and outcomes, and no consensus exists regarding the composition of optimal CPB priming solution. This study aimed to examine the impact of high oncotic pressure priming by the addition of 20% human albumin on outcomes. Methods: Double-blinded, randomized controlled study was done in the pediatric cardiac intensive care unit of a tertiary care hospital. Consecutive children with congenital heart diseases admitted for open-heart surgery were randomized into two groups, where the study group received an additional 20% albumin to conventional blood prime before CPB initiation. Results: We enrolled 39 children in the high oncotic prime (added albumin) group and 37 children in the conventional prime group. In the first 24-hour postoperative period, children in the albumin group had significantly lower occurrence of hypotension (28.2% vs 54%, P = .02), requirement of fluid boluses (25.6% vs 54%, P = .006), and lactate clearance time (6 vs 9 hours, P < .001). Albumin group also had significantly higher platelet count (×103/µL) at 24 hours (112 vs 91, P = .02). There was no significant difference in intra-CPB hemodynamic parameters and incidence of acute kidney injury. In subgroup analysis based on risk category, significantly decreased intensive care unit stay (4 vs 5 days, P = .04) and hospital stay (5 vs 7 days, P = .002) were found in the albumin group in low-risk category. Conclusion: High oncotic pressure CPB prime using albumin addition might be beneficial over conventional blood prime, and our study does provide a rationale for further studies.

scholarly journals Effect of high-dose ulinastatin on the cardiopulmonary bypass-induced inflammatory response in patients undergoing open-heart surgery

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yu Liu ◽  
Ying-Lin Wang ◽  
Shao-Hua Zou ◽  
Peng-Fei Sun ◽  
Quan Zhao
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
High Dose ◽  
Open Heart

Impact of Miniaturization of Cardiopulmonary Bypass Circuit on Blood Transfusion Requirement in Neonatal Open-Heart Surgery

ASAIO Journal ◽  
2007 ◽  
Vol 53 (6) ◽  
pp. 662-665 ◽  
Author(s):  
Yasuhiro Kotani ◽  
Osami Honjo ◽  
Mahito Nakakura ◽  
Shinya Ugaki ◽  
Takuya Kawabata ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Transfusion ◽  
Heart Surgery ◽  
Transfusion Requirement ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Blood Transfusion Requirement
Sign in / Sign up

Export Citation Format

Share Document